Paul M.L. Janssen

Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium.

Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat.

Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium.

Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange.

Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium.

Physiological determinants of contractile force generation and calcium handling in mouse myocardium.

Selective contractile dysfunction of left, not right, ventricular myocardium in the SHHF rat.

Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.

Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium.

Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure.

Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.

Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice.

Effect of muscle dimensions on trabecular contractile performance under physiological conditions.

Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility.

Murine strain differences in contractile function are temperature- and frequency-dependent.

Frequency-dependent contractile response of isolated cardiac trabeculae under hypo-, normo-, and hyperthermic conditions.

Measurement of myofilament calcium sensitivity at physiological temperature in intact cardiac trabeculae.

LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling.

SERCA overexpression reduces hydroxyl radical injury in murine myocardium.

Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity.

Frequency-dependent contractile strength in mice over- and underexpressing the sarco(endo)plasmic reticulum calcium-ATPase.

Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.

Influence of pyruvate on economy of contraction in isolated rabbit myocardium.

Atrial glutathione content, calcium current, and contractility.

A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure for treatment of Duchenne muscular dystrophy.

Determinants of frequency-dependent contraction and relaxation of mammalian myocardium.

Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium.

Gender comparison of contractile performance and beta-adrenergic response in isolated rat cardiac trabeculae.

Dissociation of force decline from calcium decline by preload in isolated rabbit myocardium.

Molecular basis of diastolic dysfunction.

Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.

Claudin-5 levels are reduced in human end-stage cardiomyopathy.

Truncated CASK does not alter skeletal muscle or protein interactors.

Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice.

The positive force-frequency relationship is maintained in absence of sarcoplasmic reticulum function in rabbit, but not in rat myocardium.

Temporal changes in expression of connexin 43 after load-induced hypertrophy in vitro.

Pulmonary artery banding alters the expression of Ca2+ transport proteins in the right atrium in rabbits.

Variability in interbeat duration influences myocardial contractility in rat cardiac trabeculae.

A random cycle length approach for assessment of myocardial contraction in isolated rabbit myocardium.

Impairment of diastolic function by lack of frequency-dependent myofilament desensitization rabbit right ventricular hypertrophy.

Nitroxyl enhances myocyte Ca2+ transients by exclusively targeting SR Ca2+-cycling.

Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies.

Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions.

Follistatin gene delivery enhances muscle growth and strength in nonhuman primates.

A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease.

Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere.

Myocardial contraction-relaxation coupling.

Lengthening-contractions in isolated myocardium impact force development and worsen cardiac contractile function in the mdx mouse model of muscular dystrophy.

Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy.

Challenges in cardiac muscle physiology.

Effects of hydroxyl radical induced-injury in atrial versus ventricular myocardium of dog and rabbit.

In vitro studies of early cardiac remodeling: impact on contraction and calcium handling.

Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.

Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice.

Effect of twitch interval duration on the contractile function of subsequent twitches in isolated rat, rabbit, and dog myocardium under physiological conditions.

mdx(⁵cv) mice manifest more severe muscle dysfunction and diaphragm force deficits than do mdx Mice.

Contractile strength during variable heart duration is species and preload dependent.

IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.

Contractile parameters and occurrence of alternans in isolated rat myocardium at supra-physiological stimulation frequency.

Effects of increased preload on the force-frequency response and contractile kinetics in early stages of cardiac muscle hypertrophy.

Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in a muscular dystrophy mouse model.

Staurosporine inhibits frequency-dependent myofilament desensitization in intact rabbit cardiac trabeculae.

The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C.

Homologous recombination mediates functional recovery of dysferlin deficiency following AAV5 gene transfer.

Cardiomyopathy in the dystrophin/utrophin-deficient mouse model of severe muscular dystrophy is characterized by dysregulation of matrix metalloproteinases.

Impact of hydroxyl radical-induced injury on calcium handling and myofilament sensitivity in isolated myocardium.

Role of endothelin in the induction of cardiac hypertrophy in vitro.

Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis.

Effects of increased systolic Ca(2+) and β-adrenergic stimulation on Ca(2+) transient decline in NOS1 knockout cardiac myocytes.

Vascular remodeling-associated hypertension leads to left ventricular hypertrophy and contractile dysfunction in profilin-1 transgenic mice.

Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium.

Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.

The force-temperature relationship in healthy and dystrophic mouse diaphragm; implications for translational study design.

Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation.

Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature.

Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles.

N-Glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in α-sarcoglycan-deficient mice.

The positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity.

Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia.

Micro-dystrophin and follistatin co-delivery restores muscle function in aged DMD model.

Small and large animal models in cardiac contraction research: advantages and disadvantages.

Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy.