Joachim Thiem

Membrane-permeant derivatives of mannose-1-phosphate.

A facile approach to diosgenin and furostan type saponins bearing a 3beta-chacotriose moiety.

Syntheses of unnatural N-substituted UDP-galactosamines as alternative substrates for N-acetylgalactosaminyl transferases.

Fungal beta-N-acetylhexosaminidases with high beta-N-acetylgalactosaminidase activity and their use for synthesis of beta-GalNAc-containing oligosaccharides.

Fast and efficient synthesis of a novel homologous series of L-fucosylated trisaccharides using the Helix pomatia alpha-(1-->2)-L-galactosyltransferase.

Novel O-glycosyl amino acid mimetics as building blocks for O-glycopeptides act as inhibitors of galactosidases.

Synthesis of rhamnosylated diosgenyl glucosides as mimetics of cytostatic steroidal saponins from Ornithogalum saindersiae and Galtonia candicans.

Formation of LacNAc mimetics employing novel donor substrates for enzymatic beta 1-->4 galactosylation.

Enzyme-catalysed synthesis of galactosylated 1D- and 1L-chiro-inositol, 1D-pinitol, myo-inositol and selected derivatives using the beta-galactosidase from the thermophile Thermoanaerobacter sp. strain TP6-B1.

Preparation of sialylated oligosaccharides employing recombinant trans-sialidase from Trypanosoma cruzi.

Endothelial effects of 3-hydroxyglutaric acid: implications for glutaric aciduria type I.

Artificial N-functionalized UDP-glucosamine analogues as modified substrates for N-acetylglucosaminyl transferases.

In vitro sulfation of N-acetyllactosaminide by soluble recombinant human beta-Gal-3'-sulfotransferase.

Synthesis of Neu5Ac oligosaccharides and analogues by transglycosylation and their binding properties as ligands to MAG.

Highly functionalized glyco-conjugated hexahydroazepindiones from saccharide imides via the Norrish type II reaction.

Synthesis and transformation of glycosyl azides.

Synthesis and evaluation of glycosyl donors with novel leaving groups for transglycosylations employing beta-galactosidase from bovine testes.

3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3.

From lactose towards a novel galactosylated cyclooctenone.

Tandem exploitation of Helix pomatia glycosyltransferases: facile syntheses of H-antigen-bearing oligosaccharides.

Donor substrate binding to trans-sialidase of Trypanosoma cruzi as studied by STD NMR.

Transsialidase from Trypanosoma cruzi for regio- and stereoselective synthesis of N-acyl-modified sialylated oligosaccharides and measurement of transfer rates.

Transport and distribution of 3-hydroxyglutaric acid before and during induced encephalopathic crises in a mouse model of glutaric aciduria type 1.

Cross metathesis for the synthesis of novel C-sialosides.

Comparative solution and solid-phase glycosylations toward a disaccharide library.

En route to deoxygenated N-acetyllactosamine analogues employing uridyl and galactosyl transferases.

Solid-phase random glycosylation.

Glycostructures in biological systems - synthesis and function.

Enzymatic glycosylation, inhibitor design, and synthesis and formation of glyco-self assembled monolayers for simulation of recognition.

Ex post glycoconjugation of phthalocyanines.

Synthesis of benzaldehyde-functionalized glycans: a novel approach towards glyco-SAMs as a tool for surface plasmon resonance studies.

Chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-N-tetraose and sialyllacto-N-neotetraose epimer.

Sialic acid C-glycosides with aromatic residues: investigating enzyme binding and inhibition of Trypanosoma cruzi trans-sialidase.

En route to sugar-alkaloid conjugates.

Highly efficient synthesis of ketoheptoses.

Defining oxyanion reactivities in base-promoted glycosylations.

(19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells.

Synthesis and hydrolysis studies of novel glyco-functionalized platinum complexes.

Acceptor-influenced and donor-tuned base-promoted glycosylation.

Trypanosomal Trans-sialidases: Valuable Synthetic Tools and Targets for Medicinal Chemistry.

Immunocytochemistry of GLUT2, uptake of fluorescent desnitroso-streptozotocin analogs and phosphorylation of D-glucose in INS-1E cells.

Novel efficient routes to indoxyl glycosides for monitoring glycosidase activities.

Glycoconjugated amphiphilic polymers via click-chemistry for the encapsulation of quantum dots.

Expedient and versatile formation of novel amino-deoxy-ketoheptuloses.

Fluorescently labeled substrates for monitoring α1,3-fucosyltransferase IX activity.

Transglycosylations employing recombinant α- and β-galactosidases and novel donor substrates.

Some findings in transgalactosylations employing modified donor substrates.

Synthesis of fucosylated uridine conjugates as potential glycosyltransferase inhibitors.