Department of Cell and Developmental Biology
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Down-regulating protein kinase C alpha: functional cooperation between the proteasome and the endocytic system.
Cellular signalling Nov, 2009 | Pubmed ID: 19586612
Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells.
The Journal of experimental medicine May, 1999 | Pubmed ID: 10330444
Gi-mediated activation of the p42/p44 mitogen-activated protein kinases by receptor mimetic basic secretagogues is abrogated by inhibitors of endocytosis.
International immunopharmacology Apr, 2002 | Pubmed ID: 12013509
Suppression of Synaptotagmin II restrains phorbolester-induced downregulation of protein kinase Calpha by diverting the kinase from a degradative pathway to the recycling endocytic compartment.
Journal of cell science Aug, 2002 | Pubmed ID: 12118064
Synaptotagmin II negatively regulates MHC class II presentation by mast cells.
Molecular immunology Sep, 2002 | Pubmed ID: 12217406
The molecular mechanisms of allergic diseases: immunoglobulin E dependent and independent signaling pathways converge in eliciting the release of arachidonic acid metabolites.
The Israel Medical Association journal : IMAJ Nov, 2002 | Pubmed ID: 12455191
Synaptotagmin III is a critical factor for the formation of the perinuclear endocytic recycling compartment and determination of secretory granules size.
Journal of cell science Jan, 2003 | Pubmed ID: 12456724
Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules.
Journal of cell science Nov, 2003 | Pubmed ID: 12966166
Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta regulate IgE receptor-triggered exocytosis in cultured mast cells.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2003 | Pubmed ID: 14607934
O-glycosylation is essential for intracellular targeting of synaptotagmins I and II in non-neuronal specialized secretory cells.
Journal of cell science Apr, 2005 | Pubmed ID: 15755799
Classical protein kinase C(s) regulates targeting of synaptotagmin IX to the endocytic recycling compartment.
Journal of cell science Apr, 2005 | Pubmed ID: 15784685
Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta stimulate extracellular signal-regulated kinase 1/2 signaling by accelerating recycling through the endocytic recycling compartment.
Molecular biology of the cell Sep, 2006 | Pubmed ID: 16837555
Synaptotagmin (Syt) IX is an essential determinant for protein sorting to secretory granules in mast cells.
Blood Apr, 2007 | Pubmed ID: 17164344
The mast cell: where endocytosis and regulated exocytosis meet.
Immunological reviews Jun, 2007 | Pubmed ID: 17498067
Molecular impacts of rapamycin-based drug combinations: combining rapamycin with gemcitabine or imatinib mesylate (Gleevec) in a human leiomyosarcoma model.
International journal of oncology Jul, 2007 | Pubmed ID: 17549426
Inhibition of basic secretagogue-induced signaling in mast cells by cell permeable G alpha i-derived peptides.
International archives of allergy and immunology , 2008 | Pubmed ID: 17848806
Targeting mTOR in HIV-Negative Classic Kaposi's Sarcoma.
Sarcoma , 2008 | Pubmed ID: 18509482
Targeting the mammalian target of rapamycin in myxoid chondrosarcoma.
Anti-cancer drugs Nov, 2008 | Pubmed ID: 18827568
Activation of mast cells by trimeric G protein Gi3; coupling to the A3 adenosine receptor directly and upon T cell contact.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2010 | Pubmed ID: 20190146
Protein trafficking in immune cells.
Immunobiology , 2009 | Pubmed ID: 20373532
Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: a beneficial strategy to combat non-small cell lung cancer.
Cancer letters Nov, 2011 | Pubmed ID: 21807458
Mast cell adenosine receptors function: a focus on the a3 adenosine receptor and inflammation.
Frontiers in immunology , 2012 | Pubmed ID: 22675325
Decoding the regulation of mast cell exocytosis by networks of Rab GTPases.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2012 | Pubmed ID: 22826321
Clinical activity of mTOR inhibition in combination with cyclophosphamide in the treatment of recurrent unresectable chondrosarcomas.
Cancer chemotherapy and pharmacology Dec, 2012 | Pubmed ID: 23053256
The extra-cellular signal regulated kinases ERK1 and ERK2 segregate displaying distinct spatiotemporal characteristics in activated mast cells.
Biochimica et biophysica acta Sep, 2013 | Pubmed ID: 23651922
Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.
Journal of immunology (Baltimore, Md. : 1950) May, 2014 | Pubmed ID: 24696234
Characterization of mast cell secretory granules and their cell biology.
DNA and cell biology Oct, 2014 | Pubmed ID: 24988214
Down-regulation of the A3 adenosine receptor in human mast cells upregulates mediators of angiogenesis and remodeling.
Molecular immunology Jan, 2015 | Pubmed ID: 25597247
Rab12 Regulates Retrograde Transport of Mast Cell Secretory Granules by Interacting with the RILP-Dynein Complex.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2016 | Pubmed ID: 26740112
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy Jan, 2016 | Pubmed ID: 26799652
Different activation signals induce distinct mast cell degranulation strategies.
The Journal of clinical investigation Oct, 2016 | Pubmed ID: 27643442
Mast cells are directly activated by contact with cancer cells by a mechanism involving autocrine formation of adenosine and autocrine/paracrine signaling of the adenosine A3 receptor.
Cancer letters 07, 2017 | Pubmed ID: 28342985
Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis.
Scientific reports Nov, 2017 | Pubmed ID: 29127297
RBL cells as models for in vitro studies of mast cells and basophils.
Immunological reviews Mar, 2018 | Pubmed ID: 29431208
1Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University,
2Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine,
3Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University
Ofir Klein1,
Amit Roded1,
Koret Hirschberg2,
Mitsunori Fukuda3,
Stephen J. Galli4,
Ronit Sagi-Eisenberg1
1Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University,
2Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University,
3Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University,
4Departments of Pathology and of Microbiology and Immunology and Sean N. Parker Center for Allergy and Asthma Research, School of Medicine, Stanford University
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