John L. R. Rubenstein

Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons.

Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression.

Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.

Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections.

Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other.

Distinct origins of neocortical projection neurons and interneurons in vivo.

Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis.

Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage.

Specification of jaw subdivisions by Dlx genes.

Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex.

Developmental functions of the Distal-less/Dlx homeobox genes.

Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.

The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice.

DLX5 regulates development of peripheral and central components of the olfactory system.

Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding.

Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain.

Cell migration in the forebrain.

Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction.

Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants.

Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters.

Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia.

Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus.

The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain.

Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4.

Forebrain gene expression domains and the evolving prosomeric model.

Beyond laminar fate: toward a molecular classification of cortical projection/pyramidal neurons.

Expression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complex.

Expression of regulatory genes during differentiation of thalamic nuclei in mouse and monkey.

A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development.

Intermediate targets in formation of topographic projections: inputs from the thalamocortical system.

Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon.

Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1.

Fgf8 regulates the development of intra-neocortical projections.

Identification of Tbr-1/CASK complex target genes in neurons.

Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina.

The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain.

Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families.

Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy.

Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb.

Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.

The nuclear receptor COUP-TFI represses differentiation of Cajal-Retzius cells.

Analysis of four DLX homeobox genes in autistic probands.

Patterning and plasticity of the cerebral cortex.

Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development.

New neurons follow the flow of cerebrospinal fluid in the adult brain.

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers.

Severe hearing loss in Dlxl mutant mice.

Can autism speak to neuroscience?

Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.

Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation.

Patterning of frontal cortex subdivisions by Fgf17.

Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation.

Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons.

Dlx transcription factors promote migration through repression of axon and dendrite growth.

A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors.

Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain.

Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes.

Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development.

COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.

Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling.

Conserved pattern of OTP-positive cells in the paraventricular nucleus and other hypothalamic sites of tetrapods.

Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain.

Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2.

Genetic regulation of prefrontal cortex development and function.

Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants.

FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.

Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs.

Characterization of a distinct subpopulation of striatal projection neurons expressing the Dlx genes in the basal ganglia through the activity of the I56ii enhancer.

Functional disturbances in the striatum by region-specific ablation of NMDA receptors.

Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons.

Autism and brain development.

Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons.

Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.

Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.

Genes and signaling events that establish regional patterning of the mammalian forebrain.

Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice.

Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult mice.

Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons.

Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice.

Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons.

Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder.

A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.

The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons.

Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times.

Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development.

Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons.

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.

New neurons clear the path of astrocytic processes for their rapid migration in the adult brain.

An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain.

Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders.

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes.

CXCR4 and CXCR7 have distinct functions in regulating interneuron migration.

Identification of direct downstream targets of Dlx5 during early inner ear development.

Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development.

Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals.

Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons.

Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala.

Deriving excitatory neurons of the neocortex from pluripotent stem cells.

Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors.

Influence of a subtype of inhibitory interneuron on stimulus-specific responses in visual cortex.

A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8.

Erratum to: Role for TGF-β superfamily signaling in telencephalic GABAergic neuron development.

COUP-TFII controls amygdala patterning by regulating neuropilin expression.

Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex.

Nuclear receptor COUP-TFII-expressing neocortical interneurons are derived from the medial and lateral/caudal ganglionic eminence and define specific subsets of mature interneurons.

Hilar GABAergic interneuron activity controls spatial learning and memory retrieval.

Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms.

Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate.

Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants.

Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.

A high-resolution enhancer atlas of the developing telencephalon.

New insights into the classification and nomenclature of cortical GABAergic interneurons.

A Subpopulation of Individual Neural Progenitors in the Mammalian Dorsal Pallium Generates Both Projection Neurons and Interneurons vitro.

CoupTFI interacts with retinoic acid signaling during cortical development.

Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.

Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons.

Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons.

Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons.

Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon.

Many human accelerated regions are developmental enhancers.

Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes.

Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo.

Rapid and pervasive changes in genome-wide enhancer usage during mammalian development.

Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.

Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex.

Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position.

Major progress towards elucidating brain wiring diagrams.

Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex.

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.

Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation.

NPAS1 represses the generation of specific subtypes of cortical interneurons.

Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.

Genomic perspectives of transcriptional regulation in forebrain development.

Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in dlx5/6(+/-) mice.

A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model.