Department of Neuroscience,
Institute for Translational Neuroscience
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Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.
Neurobiology of aging Mar-Apr, 2002 | Pubmed ID: 11804700
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2002 | Pubmed ID: 12084935
No-reflow is an independent predictor of death and myocardial infarction after percutaneous coronary intervention.
American heart journal Jan, 2003 | Pubmed ID: 12514653
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Human molecular genetics Jan, 2004 | Pubmed ID: 14645205
Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations.
Journal of neurochemistry Jan, 2004 | Pubmed ID: 14690528
Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2004 | Pubmed ID: 15317865
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.
Human molecular genetics Jan, 2005 | Pubmed ID: 15525661
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2005 | Pubmed ID: 15684072
Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases.
Neurobiology of aging Aug-Sep, 2005 | Pubmed ID: 15917102
Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity.
Journal of neurochemistry Jun, 2005 | Pubmed ID: 15935070
Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2005 | Pubmed ID: 15944382
Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice.
Neurobiology of disease Feb, 2006 | Pubmed ID: 16230020
Ruptured left gastric artery aneurysm: unique presentation with hemothorax and hemomediastinum.
Cardiovascular and interventional radiology May-Jun, 2006 | Pubmed ID: 16283575
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2006 | Pubmed ID: 16399671
Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis.
Cancer research Apr, 2006 | Pubmed ID: 16585202
Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2006 | Pubmed ID: 16597723
Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.
Experimental neurology Mar, 2007 | Pubmed ID: 17254569
Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases.
Neurobiology of aging Apr, 2008 | Pubmed ID: 17316906
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility.
The American journal of pathology Nov, 2007 | Pubmed ID: 17872978
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
Human molecular genetics Feb, 2008 | Pubmed ID: 17981811
Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research Nov, 2008 | Pubmed ID: 19010849
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2008 | Pubmed ID: 19091971
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.
Neuron Jan, 2010 | Pubmed ID: 20152114
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.
Human molecular genetics Jun, 2010 | Pubmed ID: 20185556
Passive (amyloid-β) immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice.
Journal of Alzheimer's disease : JAD , 2011 | Pubmed ID: 20966549
Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.
PloS one , 2011 | Pubmed ID: 21304957
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
PloS one , 2011 | Pubmed ID: 21494637
Magnetization transfer and adiabatic R 1ρ MRI in the brainstem of Parkinson's disease.
Parkinsonism & related disorders Jun, 2012 | Pubmed ID: 22265140
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.
Human molecular genetics Jun, 2012 | Pubmed ID: 22357653
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2012 | Pubmed ID: 22399752
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2012 | Pubmed ID: 22399753
Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses.
Clinical cancer research : an official journal of the American Association for Cancer Research Jun, 2014 | Pubmed ID: 24727327
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