Department of Chemistry
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Novel lipase-catalysed highly selective acetylation studies on D-arabino- and D-threo-polyhydroxyalkyltriazoles.
Bioorganic & medicinal chemistry Apr, 2002 | Pubmed ID: 11836103
Synthesis and antiviral activity evaluation of novel 2-phenyl-4-(D-arabino-4'-cycloaminobutyl)triazoles: acyclonucleosides containing unnatural bases.
Bioorganic & medicinal chemistry Apr, 2002 | Pubmed ID: 11836105
Local disruption of DNA-base stacking by bulky base surrogates.
Chemical communications (Cambridge, England) Mar, 2002 | Pubmed ID: 12120560
Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate.
Bioorganic & medicinal chemistry letters Sep, 2002 | Pubmed ID: 12182864
Xanthones as inhibitors of microsomal lipid peroxidation and TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs).
Bioorganic & medicinal chemistry Nov, 2002 | Pubmed ID: 12213456
Establishment of the enzymatic protein acetylation independent of acetyl CoA: recombinant glutathione S-transferase 3-3 is acetylated by a novel membrane-bound transacetylase using 7,8-diacetoxy-4-methyl coumarin as the acetyl donor.
FEBS letters Oct, 2002 | Pubmed ID: 12387881
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 9: comparison of acetoxy 4-methylcoumarins and other polyphenolic acetates reveal the specificity to acetoxy drug: protein transacetylase for pyran carbonyl group in proximity to the oxygen heteroatom.
Bioorganic & medicinal chemistry Dec, 2002 | Pubmed ID: 12413864
Synthetic and novel biocatalytic resolution studies on (+/-)-5/6/7-acetoxy-4-aryl-3,4-dihydrocoumarins.
Bioorganic & medicinal chemistry Feb, 2003 | Pubmed ID: 12538018
Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds.
Bioorganic & medicinal chemistry Mar, 2003 | Pubmed ID: 12614877
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 10: identification of inhibitors for the liver microsomal acetoxycoumarin: protein transacetylase.
Bioorganic & medicinal chemistry Mar, 2003 | Pubmed ID: 12614887
Polycyclic aromatic DNA-base surrogates: high-affinity binding to an adenine-specific base-flipping DNA methyltransferase.
Angewandte Chemie (International ed. in English) Aug, 2003 | Pubmed ID: 12949880
Naturally occurring aristolactams, aristolochic acids and dioxoaporphines and their biological activities.
Natural product reports Dec, 2003 | Pubmed ID: 14700200
Oligodeoxynucleotides containing alpha-L-ribo configured LNA-type C-aryl nucleotides.
Organic & biomolecular chemistry Jan, 2004 | Pubmed ID: 14737663
1,4-dihydroxyxanthone modulates the adhesive property of endothelial cells by inhibiting intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin.
Bioorganic & medicinal chemistry Mar, 2004 | Pubmed ID: 15018916
"Green"-enzymatic synthesis of pegylated phenolic macromer and polymer.
Chemical communications (Cambridge, England) Apr, 2004 | Pubmed ID: 15045101
Acetoxy drug: protein transacetylase of buffalo liver-characterization and mass spectrometry of the acetylated protein product.
Biochimica et biophysica acta Apr, 2004 | Pubmed ID: 15063315
Enzymatic synthesis of multi-component copolymers and their structural characterization.
Molecular diversity , 2003 | Pubmed ID: 15068093
Supramolecular assemblies based on copolymers of PEG600 and functionalized aromatic diesters for drug delivery applications.
Journal of the American Chemical Society Sep, 2004 | Pubmed ID: 15327322
Conformationally controlled high-affinity targeting of RNA or DNA by novel 2'-amino-DNA/LNA mixmers and pyrenyl-functionalized 2'-amino-DNA.
Organic & biomolecular chemistry Oct, 2004 | Pubmed ID: 15480448
Influence of EDA-pi interactions in drug encapsulation using nanospheres.
Chemical communications (Cambridge, England) Dec, 2004 | Pubmed ID: 15568069
Novel thiocoumarins as inhibitors of TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs) and microsomal lipid peroxidation.
Bioorganic & medicinal chemistry Mar, 2005 | Pubmed ID: 15698778
Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation.
FEBS letters Mar, 2005 | Pubmed ID: 15757658
Mechanism of biochemical action of substituted 4-methylcoumarins. Part 11: Comparison of the specificities of acetoxy derivatives of 4-methylcoumarin and 4-phenylcoumarin to acetoxycoumarins: protein transacetylase.
Bioorganic & medicinal chemistry Jul, 2005 | Pubmed ID: 15878663
'Green' methodology for efficient and selective benzoylation of nucleosides using benzoyl cyanide in an ionic liquid.
Bioorganic & medicinal chemistry Jul, 2005 | Pubmed ID: 15921912
Acetoxy drug: protein transacetylase catalyzed activation of human platelet nitric oxide synthase by polyphenolic peracetates.
Bioorganic & medicinal chemistry Jan, 2006 | Pubmed ID: 16214347
Microwave-assisted synthesis of antimicrobial dihydropyridines and tetrahydropyrimidin-2-ones: novel compounds against aspergillosis.
Bioorganic & medicinal chemistry Feb, 2006 | Pubmed ID: 16214352
Mild, efficient, selective and "green" benzoylation of nucleosides using benzoyl cyanide in ionic liquid.
Nucleosides, nucleotides & nucleic acids , 2005 | Pubmed ID: 16248029
Novel aromatic ester from Piper longum and its analogues inhibit expression of cell adhesion molecules on endothelial cells.
Biochemistry Dec, 2005 | Pubmed ID: 16313198
DNA and LNA oligonucleotides containing N2'-functionalised derivatives of 2'-amino-2'-deoxyuridine.
Bioorganic & medicinal chemistry letters Jun, 2006 | Pubmed ID: 16621554
QSAR modeling of anti-invasive activity of organic compounds using structural descriptors.
Bioorganic & medicinal chemistry Oct, 2006 | Pubmed ID: 16908166
Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase.
European journal of medicinal chemistry Apr, 2007 | Pubmed ID: 17182154
Ellagic acid peracetate is superior to ellagic acid in the prevention of genotoxicity due to aflatoxin B1 in bone marrow and lung cells.
The Journal of pharmacy and pharmacology Jan, 2007 | Pubmed ID: 17227624
A chromone analog inhibits TNF-alpha induced expression of cell adhesion molecules on human endothelial cells via blocking NF-kappaB activation.
Bioorganic & medicinal chemistry Apr, 2007 | Pubmed ID: 17321745
Transition metal-catalyzed orthogonal solid-phase decoration of the 2(1H)-pyrazinone scaffold using a sulfur linker.
Journal of combinatorial chemistry May-Jun, 2007 | Pubmed ID: 17373850
Characterization of protein transacetylase from human placenta as a signaling molecule calreticulin using polyphenolic peracetates as the acetyl group donors.
Cell biochemistry and biophysics , 2007 | Pubmed ID: 17420526
7,8-Dihydroxy-4-methylcoumarin induces apoptosis of human lung adenocarcinoma cells by ROS-independent mitochondrial pathway through partial inhibition of ERK/MAPK signaling.
FEBS letters May, 2007 | Pubmed ID: 17485089
E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins.
Bioorganic & medicinal chemistry Sep, 2007 | Pubmed ID: 17562365
Deacylation studies on furanose triesters using an immobilized lipase: synthesis of a key precursor for bicyclonucleosides.
Chemical communications (Cambridge, England) Jul, 2007 | Pubmed ID: 17579756
Piper longum Linn. Extract inhibits TNF-alpha-induced expression of cell adhesion molecules by inhibiting NF-kappaB activation and microsomal lipid peroxidation.
Phytomedicine : international journal of phytotherapy and phytopharmacology Apr, 2008 | Pubmed ID: 17689945
Synthesis and applications of novel bis(ammonium) chiral ionic liquids derived from isomannide.
Organic letters Sep, 2007 | Pubmed ID: 17725360
Selective biocatalytic deacylation studies on furanose triesters: a novel and efficient approach towards bicyclonucleosides.
Organic & biomolecular chemistry Nov, 2007 | Pubmed ID: 17943213
Antioxidant activity of 4-methylcoumarins.
The Journal of pharmacy and pharmacology Dec, 2007 | Pubmed ID: 18053335
Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides.
Nucleosides, nucleotides & nucleic acids , 2007 | Pubmed ID: 18066818
Synthesis and antimicrobial activity of 3-arylamino-1-chloropropan-2-ols.
Bioorganic & medicinal chemistry letters Mar, 2008 | Pubmed ID: 18281215
Calreticulin transacetylase mediates the acetylation of nitric oxide synthase by polyphenolic acetate.
Applied biochemistry and biotechnology Jan, 2008 | Pubmed ID: 18415985
Efficient and selective enzymatic acylation reaction: separation of furanosyl and pyranosyl nucleosides.
The Journal of organic chemistry Jul, 2008 | Pubmed ID: 18557651
Greener biocatalytic approach to the synthesis of nucleosides and their precursors.
Nucleic acids symposium series (2004) , 2008 | Pubmed ID: 18776359
Autoacetylation of purified calreticulin transacetylase utilizing acetoxycoumarin as the acetyl group donor.
Applied biochemistry and biotechnology May, 2009 | Pubmed ID: 18795239
Apoptogenic effect of 7,8-diacetoxy-4-methylcoumarin and 7,8-diacetoxy-4-methylthiocoumarin in human lung adenocarcinoma cell line: role of NF-kappaB, Akt, ROS and MAP kinase pathway.
Chemico-biological interactions May, 2009 | Pubmed ID: 19061872
Specificities of calreticulin transacetylase to acetoxy derivatives of 3-alkyl-4-methylcoumarins: effect on the activation of nitric oxide synthase.
Bioorganic & medicinal chemistry Feb, 2009 | Pubmed ID: 19181531
Moonlighting protein in Starkeyomyces koorchalomoides: characterization of dihydrolipoamide dehydrogenase as a protein acetyltransferase utilizing acetoxycoumarin as the acetyl group donor.
Biochimie Jul, 2009 | Pubmed ID: 19383527
Synthesis and hybridization studies of alpha-configured arabino nucleic acids.
Organic & biomolecular chemistry Jun, 2009 | Pubmed ID: 19462050
Design, synthesis and anti-inflammatory evaluation of PEGylated 4-methyl and 4,8-dimethylcoumarins.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jan, 2010 | Pubmed ID: 19948217
Calreticulin transacylase: genesis, mechanism of action and biological applications.
Biochimie Sep, 2010 | Pubmed ID: 20109516
Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore.
Bioorganic & medicinal chemistry letters Mar, 2010 | Pubmed ID: 20149656
Structural modifications of nucleosides in ionic liquids.
Biochimie Sep, 2010 | Pubmed ID: 20178825
Calreticulin transacetylase catalyzed modification of the TNF-alpha mediated pathway in the human peripheral blood mononuclear cells by polyphenolic acetates.
Chemico-biological interactions May, 2010 | Pubmed ID: 20188080
In vitro interactions of coumarins with iron.
Biochimie Sep, 2010 | Pubmed ID: 20381579
Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds.
Organic & biomolecular chemistry May, 2010 | Pubmed ID: 20401400
4-methylcoumarins as antioxidants: scavenging of peroxyl radicals and inhibition of human low-density lipoprotein oxidation.
Biochimie Sep, 2010 | Pubmed ID: 20434515
Synthesis, Src kinase inhibitory and anticancer activities of 1-substituted 3-(N-alkyl-N-phenylamino)propane-2-ols.
Biochimie Sep, 2010 | Pubmed ID: 20447438
Characterization of 4-methyl-2-oxo-1,2-dihydroquinolin-6-yl acetate as an effective antiplatelet agent.
Bioorganic & medicinal chemistry Jun, 2010 | Pubmed ID: 20447827
beta-sitosterol among other secondary metabolites of Piper galeatum shows inhibition of TNFalpha-induced cell adhesion molecule expression on human endothelial cells.
Biochimie Sep, 2010 | Pubmed ID: 20558233
Structure-activity relationship of dihydroxy-4-methylcoumarins as powerful antioxidants: correlation between experimental & theoretical data and synergistic effect.
Biochimie Sep, 2010 | Pubmed ID: 20600568
Specificity of calreticulin transacetylase to acetoxy derivatives of benzofurans: effect on the activation of platelet nitric oxide synthase.
Biochimie Sep, 2010 | Pubmed ID: 20600569
A spectroelectrochemical and chemical study on oxidation of 7,8-dihydroxy-4-methylcoumarin (DHMC) and some related compounds in aprotic medium.
Biochimie Sep, 2010 | Pubmed ID: 20600572
Novel coumarin-based tyrosinase inhibitors discovered by OECD principles-validated QSAR approach from an enlarged, balanced database.
Molecular diversity May, 2011 | Pubmed ID: 20814821
Biocatalytic separation of N-7/N-9 guanine nucleosides.
The Journal of organic chemistry Nov, 2010 | Pubmed ID: 20973519
7, 8-diacetoxy-4-methylcoumarin induced cell death in human tumor cells is influenced by calreticulin.
Biochimie Mar, 2011 | Pubmed ID: 21075165
Protein acyltransferase function of purified calreticulin: the exclusive role of P-domain in mediating protein acylation utilizing acyloxycoumarins and acetyl CoA as the acyl group donors.
Protein and peptide letters May, 2011 | Pubmed ID: 21235489
Characterization of protein acyltransferase function of recombinant purified GlnA1 from Mycobacterium tuberculosis: a moon lighting property.
Microbiological research Dec, 2011 | Pubmed ID: 21411303
Selective biocatalytic aminolysis of (±)-epichlorohydrin: synthesis and ICAM-1 inhibitory activity of (S)-(+)-3-arylamino-1-chloropropan-2-ols.
Bioorganic & medicinal chemistry Apr, 2011 | Pubmed ID: 21419631
Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences May, 2011 | Pubmed ID: 21426935
Normalization of deranged signal transduction in lymphocytes of COPD patients by the novel calcium channel blocker H-DHPM.
Biochimie Jul, 2011 | Pubmed ID: 21527308
Short- and long-term regulation of 3-hydroxy 3-methylglutaryl coenzyme A reductase by a 4-methylcoumarin.
Biochimie Jul, 2011 | Pubmed ID: 21530605
Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.
Journal of medicinal chemistry Jun, 2011 | Pubmed ID: 21539383
Tetrasubstituted 2-imidazolones via Ag(I)-catalyzed cycloisomerization of propargylic ureas.
The Journal of organic chemistry Jul, 2011 | Pubmed ID: 21639124
Design, synthesis and bioevaluation of novel candidate selective estrogen receptor modulators.
European journal of medicinal chemistry Sep, 2011 | Pubmed ID: 21680064
Characterization of a unique dihydropyrimidinone, ethyl 4-(4'-heptanoyloxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylate, as an effective antithrombotic agent in a rat experimental model.
The Journal of pharmacy and pharmacology Sep, 2011 | Pubmed ID: 21827490
Biocatalytic route to sugar-PEG-based polymers for drug delivery applications.
Biomacromolecules Oct, 2011 | Pubmed ID: 21834595
Characterization of 7-amino-4-methylcoumarin as an effective antitubercular agent: structure-activity relationships.
The Journal of antimicrobial chemotherapy Nov, 2011 | Pubmed ID: 21917615
Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells.
European journal of medicinal chemistry Nov, 2011 | Pubmed ID: 21955679
Calreticulin Transacetylase mediated activation of human platelet nitric oxide synthase by acetyl group donor compounds.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society Jan, 2012 | Pubmed ID: 22100620
Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-α induced expression of ICAM-1: structure-activity analysis.
Archiv der Pharmazie May, 2012 | Pubmed ID: 22190402
Glycine-terminated dendritic amphiphiles for nonviral gene delivery.
Biomacromolecules Oct, 2012 | Pubmed ID: 22877231
A diversity-oriented approach to spiroindolines: post-Ugi gold-catalyzed diastereoselective domino cyclization.
Angewandte Chemie (International ed. in English) Sep, 2012 | Pubmed ID: 22907654
In vitro platelet antiaggregatory properties of 4-methylcoumarins.
Biochimie Dec, 2012 | Pubmed ID: 22996069
Gold(I) and platinum(II) switch: a post-Ugi intramolecular hydroarylation to pyrrolopyridinones and pyrroloazepinones.
Chemical communications (Cambridge, England) Nov, 2012 | Pubmed ID: 23032641
O-Aryl α,β-d-ribofuranosides: synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity.
Bioorganic & medicinal chemistry Dec, 2012 | Pubmed ID: 23098606
A novel cinnamate derivative attenuates asthma features and reduces bronchial epithelial injury in mouse model.
International immunopharmacology Jan, 2013 | Pubmed ID: 23137769
Comparative specificities of Calreticulin Transacetylase to O-acetyl, N-acetyl and S-acetyl derivative of 4-methylcoumarins and their inhibitory effect on AFB1-induced genotoxicity in vitro and in vivo.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Feb, 2013 | Pubmed ID: 23182742
Selective biocatalytic acylation studies on 5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine: an efficient synthesis of UNA monomer.
Nucleosides, nucleotides & nucleic acids , 2012 | Pubmed ID: 23215547
Ethyl 3',4',5'-trimethoxythionocinnamate modulates NF-κB and Nrf2 transcription factors.
European journal of pharmacology Jan, 2013 | Pubmed ID: 23261968
An expedient route to imidazo[1,4]diazepin-7-ones via a post-Ugi gold-catalyzed heteroannulation.
Organic letters Apr, 2013 | Pubmed ID: 23544989
Switching the regioselectivity via indium(III) and gold(I) catalysis: a post-Ugi intramolecular hydroarylation to azepino- and azocino-[c,d]indolones.
Chemical communications (Cambridge, England) Aug, 2013 | Pubmed ID: 23783807
Chick heart invasion assay.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24092434
Calreticulin transacetylase mediated upregulation of thioredoxin by 7,8-diacetoxy-4-methylcoumarin enhances the antioxidant potential and the expression of vascular endothelial growth factor in peripheral blood mononuclear cells.
Chemico-biological interactions Nov, 2013 | Pubmed ID: 24103856
Post-Ugi gold-catalyzed diastereoselective domino cyclization for the synthesis of diversely substituted spiroindolines.
Beilstein journal of organic chemistry , 2013 | Pubmed ID: 24204421
Novozym 435-catalyzed syntheses of polyesters and polyamides of medicinal and industrial relevance.
ChemSusChem Feb, 2014 | Pubmed ID: 24449474
Cytotoxic and radio-sensitizing effects of polyphenolic acetates in a human glioma cell line (BMG-1).
Current pharmaceutical design , 2014 | Pubmed ID: 24552186
Comparison of protein acetyltransferase action of CRTAase with the prototypes of HAT.
TheScientificWorldJournal , 2014 | Pubmed ID: 24688408
Modifications of cell signalling and redox balance by targeting protein acetylation using natural and engineered molecules: implications in cancer therapy.
Current topics in medicinal chemistry , 2014 | Pubmed ID: 25478886
The Competence Of 7,8-Diacetoxy-4-Methylcoumarinand Other Polyphenolic Acetates In Mitigating The Oxidative Stress And Their Role In Angiogenesis.
Current topics in medicinal chemistry Dec, 2014 | Pubmed ID: 25496273
Cascade N-Alkylation/Hemiacetalization for Facile Construction of the Spiroketal Skeleton of Acortatarin Alkaloids with Therapeutic Potentiality in Diabetic Nephropathy.
Natural products and bioprospecting Dec, 2014 | Pubmed ID: 25511450
Design, synthesis and bioevaluation of novel 6-(4-Hydroxypiperidino)naphthalen-2-ol-based potential Selective Estrogen Receptor Modulators for breast cancer.
European journal of medicinal chemistry Mar, 2015 | Pubmed ID: 25544690
The Competence of 7,8-Diacetoxy-4-Methylcoumarinand Other Polyphenolic Acetates in Mitigating the Oxidative Stress and their Role in Angiogenesis.
Current topics in medicinal chemistry , 2015 | Pubmed ID: 25547104
Anti-inflammatory and antioxidant properties of Piper species: a perspective from screening to molecular mechanisms.
Current topics in medicinal chemistry , 2015 | Pubmed ID: 25697561
Role of single nucleotide polymorphisms in pharmacogenomics and their association with human diseases.
Drug metabolism reviews May, 2015 | Pubmed ID: 25996670
Structure-activity relationship studies of 4-methylcoumarin derivatives as anticancer agents.
Pharmaceutical biology May, 2015 | Pubmed ID: 26017566
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