Department of Hematology/Oncology,
Tisch Cancer Institute,
Department of Hematology/Oncology, Tisch Cancer Institute
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3,3'-diindolylmethane is a novel topoisomerase IIalpha catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cells.
Molecular pharmacology Apr, 2006 | Pubmed ID: 16385077
3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells.
Cancer research May, 2006 | Pubmed ID: 16651444
Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research Nov, 2006 | Pubmed ID: 17085664
Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors.
PloS one , 2007 | Pubmed ID: 17726540
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.
PLoS medicine Oct, 2007 | Pubmed ID: 17927446
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma.
Cancer research Jul, 2008 | Pubmed ID: 18632602
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.
The Journal of clinical investigation Oct, 2009 | Pubmed ID: 19759520
High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507).
PloS one , 2009 | Pubmed ID: 19806209
EGFR mutant lung cancer.
Current topics in microbiology and immunology , 2012 | Pubmed ID: 21866438
The emerging role of circulating tumor cell detection in genitourinary cancer.
The Journal of urology Jul, 2012 | Pubmed ID: 22578722
TIMP-1 promotes accumulation of cancer associated fibroblasts and cancer progression.
PloS one , 2013 | Pubmed ID: 24143225
Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.
Cancer discovery May, 2014 | Pubmed ID: 24535670
Roles of matrix metalloproteinases and their natural inhibitors in prostate cancer progression.
Cancers , 2014 | Pubmed ID: 24978435
Elevated circulating tissue inhibitor of metalloproteinase 1 (TIMP-1) levels are associated with neuroendocrine differentiation in castration resistant prostate cancer.
The Prostate May, 2015 | Pubmed ID: 25560638
The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells.
Oncotarget Sep, 2015 | Pubmed ID: 26203774
A robust blood gene expression-based prognostic model for castration-resistant prostate cancer.
BMC medicine , 2015 | Pubmed ID: 26297150
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