Markus Heilig

[Documented effect of methadone, but not naltrexone].

Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol.

[Surprising conclusion by the SBU concerning the benefits of naltrexone in the treatment of heroin dependence].

Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test.

Brain neuropeptide Y (NPY) in stress and alcohol dependence.

[The brain behind stress and fatigue depression].

The dual-diagnosis concept used by Swedish social workers: limited validity upon examination using a structured diagnostic approach.

NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations.

Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence.

1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial.

[Researchers and psychiatrists defending Gillberg's research on ADDH: Karfve's campaign is a form of personal persecution and scientific basis is missing].

Persistent behavioral and autonomic supersensitivity to stress following prenatal stress exposure in rats.

[Ecstasy is a dangerous drug the society chooses to ignore].

Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties.

A temporal threshold for induction of persistent alcohol preference: behavioral evidence in a rat model of intermittent intoxication.

[Reduced drug craving and better social function with buprenorphine therapy. Combination therapy as an alternative to methadone therapy in heroin addiction].

Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: evidence for an allostatic shift?

Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders.

Fetus at risk: prevalence of alcohol consumption during pregnancy estimated with a simple screening method in Swedish antenatal clinics.

Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats.

Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism.

Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors.

Beliefs and reality: detection and prevention of high alcohol consumption in Swedish antenatal clinics.

High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats.

The NPY system in stress, anxiety and depression.

Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden.

Functional genomics strategies to identify susceptibility genes and treatment targets in alcohol dependence.

Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence.

Anxiolytic-like actions of centrally-administered neuropeptide Y, but not galanin, in C57BL/6J mice.

Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats.

A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence.

Unexpectedly high prevalence of alcohol use among pregnant Swedish women: failed detection by antenatal care and simple tools that improve detection.

Gene discovery in neuropharmacological and behavioral studies using Affymetrix microarray data.

Addiction and its brain science.

NPY in alcoholism and psychiatric disorders.

Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference.

Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system.

Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms.

Identifying hazardous alcohol consumption during pregnancy: implementing a research-based model in real life.

Neuroendocrine, cognitive and structural imaging characteristics of women on longterm sickleave with job stress-induced depression.

Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques.

3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.

Hazardous alcohol users during pregnancy: psychiatric health and personality traits.

Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol.

A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial.

Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar Rats.

Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence.

A key role for corticotropin-releasing factor in alcohol dependence.

Long-lasting tolerance to alcohol following a history of dependence.

Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence.

The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice.

Changes in the occurrences of coercive interventions and staff injuries on a psychiatric intensive care unit.

Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm.

Imagen: implications for addiction science and science policy.

Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence.

Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.

Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series.

Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat.

Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates.

Neuroplasticity in brain reward circuitry following a history of ethanol dependence.

Rapid tolerance and locomotor sensitization in ethanol-naïve adolescent rhesus macaques.

Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist.

CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques.

Acute ethanol challenge inhibits glycogen synthase kinase-3beta in the rat prefrontal cortex.

[New guidelines against unfair treatment of narcotic addicts necessary].

Suppressed neuroendocrine stress response in depressed women on job-stress-related long-term sick leave: a stable marker potentially suggestive of preexisting vulnerability.

Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia.

Arrestin3 mediates D(2) dopamine receptor internalization.

Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system.

Requirement of central ghrelin signaling for alcohol reward.

Functional CRH variation increases stress-induced alcohol consumption in primates.

Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus.

Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers.

Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond.

Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues.

Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking.

Gene-environment interactions and response to social intrusion in male and female rhesus macaques.

D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model.

Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice.

Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences.

Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation.

Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes.

Reward sensitivity: issues of measurement, and achieving consilience between human and animal phenotypes.

Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?

Effects of early-life stress on serotonin(1A) receptors in juvenile Rhesus monkeys measured by positron emission tomography.

Early onset alcohol dependence with high density of family history is not "male limited".

A multiplex calcium assay for identification of GPCR agonists and antagonists.

Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats.

Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques.

Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors.

Addiction research centres and the nurturing of creativity: the National Institute on Alcohol Abuse and Alcoholism.

Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats.

Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect.

Reversibility of object recognition but not spatial memory impairment following binge-like alcohol exposure in rats.

Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study.

Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse.

Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system.

Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor.

The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety.

Genetic moderators and psychiatric mediators of the link between sexual abuse and alcohol dependence.

Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain.

Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats.

Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking.

Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate.

Child μ-opioid receptor gene variant influences parent-child relations.

Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429.

Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol.

OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.

A welcome change that stops short of being fully satisfying.

Translational and reverse translational research on the role of stress in drug craving and relapse.

Translational approaches to medication development.

The biometric measurement of alcohol consumption.

Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons.

The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus.

Relationship between liver function and brain shrinkage in patients with alcohol dependence.

Pharmacogenetic approaches to the treatment of alcohol addiction.

Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats.

Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking.

Effects of the NK1 antagonist, aprepitant, on response to oral and intranasal oxycodone in prescription opioid abusers.

The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques.

Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST.

Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients.

Medications development to treat alcohol dependence: a vision for the next decade.

Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective.

The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety.

Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats.

Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: reduced appetite for calories and suppression of addictive-like behaviors.

Stress-related neuropeptides and addictive behaviors: beyond the usual suspects.

Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects.

Childhood trauma exposure and alcohol dependence severity in adulthood: mediation by emotional abuse severity and neuroticism.

Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism.

The NK1 receptor antagonist L822429 reduces heroin reinforcement.

Low vitamin D status and suicide: a case-control study of active duty military service members.

Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence.

Conditioned preference to a methamphetamine-associated contextual cue in humans.

Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats.

Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats.

Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats.

A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats.

β-Arrestin 2 knockout mice exhibit sensitized dopamine release and increased reward in response to a low dose of alcohol.

Loss of metabotropic glutamate receptor 2 escalates alcohol consumption.

Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor.

The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking.

Gender differences in neural-behavioral response to self-observation during a novel fMRI social stress task.

[Opioid dependence: New national guidelines must allow maintenance treatment].

Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors.

Acamprosate: an alcoholism treatment that may not be what we thought.

FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice.

Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats.

Stress and alcohol interactions: animal studies and clinical significance.

microRNA-206 in rat medial prefrontal cortex regulates BDNF expression and alcohol drinking.

Cerebrospinal fluid monocyte chemoattractant protein-1 in alcoholics: support for a neuroinflammatory model of chronic alcoholism.

Kappa-opioid receptor antagonism: a mechanism for treatment of relief drinking?

Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes.

Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat.

The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: a human experimental study.

Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats.

PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission.

Reduced anterior insula, enlarged amygdala in alcoholism and associated depleted von Economo neurons.

Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats.

Daniel W. Hommer.

The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study.

A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice.

Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol-dependent patients.

PPARc activation attenuates opioid consumption and modulates mesolimbic dopamine transmission.

The role of expectation in the therapeutic outcomes of alcohol and drug addiction treatments.

DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity.

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.

Circumspectives: The Replacements.

Effects of Varenicline on Neural Correlates of Alcohol Salience in Heavy Drinkers.

Neurokinin 1 receptor blockade in the medial amygdala attenuates alcohol drinking in rats with innate anxiety but not in Wistar rats.

Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects.

Circumspectives: Cannabis and Psychiatric Illness: Blunt Thoughts.

What the alcohol doctor ordered from the neuroscientist: Theragnostic biomarkers for personalized treatments.

mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts.

Tunable Diffractive Optical Elements Based on Shape-Memory Polymers Fabricated via Hot Embossing.

The melanin-concentrating hormone-1 receptor modulates alcohol-induced reward and DARPP-32 phosphorylation.

The Effect of Varenicline on the Neural Processing of Fearful Faces and the Subjective Effects of Alcohol in Heavy Drinkers.

The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects.

Characterization of comorbid PTSD in treatment-seeking alcohol dependent inpatients: Severity and personality trait differences.

The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research.

Proinflammatory signaling regulates voluntary alcohol intake and stress-induced consumption after exposure to social defeat stress in mice.

Time to connect: bringing social context into addiction neuroscience.

The mGluR2 Positive Allosteric Modulator, AZD8529, and Cue-Induced Relapse to Alcohol Seeking in Rats.

OPRM1 genotype interacts with serotonin system dysfunction to predict alcohol-heightened aggression in primates.

The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models.

Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake.

Effect of the CRF1-receptor antagonist pexacerfont on stress-induced eating and food craving.

Erratum to: The melanin-concentrating hormone-1 receptor modulates alcohol-induced reward and DARPP-32 phosphorylation.

FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence.

Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function.

Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE): A Pilot Study in Alcohol-dependent Women.

Addiction research and theory: a commentary on the Surgeon General's Report on alcohol, drugs, and health.

The GABA Positive Allosteric Modulator ADX71441 Attenuates Alcohol Self-Administration and Relapse to Alcohol Seeking in Rats.

mTORC and ProSAPiP1: How Alcohol Changes Synapses of Reward Circuitry.

Substance P and the Neurokinin-1 Receptor: The New CRF.

Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques.

Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [C] PHNO-PET pilot trial in healthy humans.

A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice.

Insula Sensitivity to Unfairness in Alcohol Use Disorder.

Neural responses to cues paired with methamphetamine in healthy volunteers.

Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABA receptors on dopamine neurons in mice.

Preclinical evaluation of the kappa-opioid receptor antagonist CERC-501 as a candidate therapeutic for alcohol use disorders.

Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use.

The salience of self, not social pain, is encoded by dorsal anterior cingulate and insula.

The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study.

A molecular mechanism for choosing alcohol over an alternative reward.

Putting a good face on touch: Facial expression reflects the affective valence of caress-like touch across modalities.

Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice.

Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers.

Science-Based Actions Can Help Address the Opioid Crisis.

Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula.

Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent C-raclopride positron emission tomography and functional magnetic resonance imaging investigation.

Distinction of self-produced touch and social touch at cortical and spinal cord levels.