Li Ka Shing Institute for Virology,
Faculty of Pharmacy and Pharmaceutical Sciences
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Easy tissue expansion of prelaminated mucosa-lined flaps for cheek reconstruction in a canine model.
Plastic and reconstructive surgery May, 2002 | Pubmed ID: 11994602
The effect of low-molecular-weight heparin in the survival of a rabbit congested skin flap.
Plastic and reconstructive surgery May, 2002 | Pubmed ID: 11994604
Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist.
Journal of medicinal chemistry Oct, 2002 | Pubmed ID: 12361385
Clinical outcome in cranioplasty: critical review in long-term follow-up.
The Journal of craniofacial surgery Mar, 2003 | Pubmed ID: 12621283
Evaluation of 45S5 bioactive glass combined as a bone substitute in the reconstruction of critical size calvarial defects in rabbits.
The Journal of craniofacial surgery Jan, 2005 | Pubmed ID: 15699647
Hypertelorism: the importance of three-dimensional imaging and trends in the surgical correction by facial bipartition.
Plastic and reconstructive surgery May, 2005 | Pubmed ID: 15861056
Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist.
Bioorganic & medicinal chemistry letters Aug, 2005 | Pubmed ID: 15982875
Melanocortin subtype 4 receptor agonists: structure-activity relationships about the 4-alkyl piperidine core.
Bioorganic & medicinal chemistry letters Oct, 2007 | Pubmed ID: 17768046
Melanotic neuroectodermal tumor of infancy: review of literature and case report.
Journal of pediatric surgery Jun, 2008 | Pubmed ID: 18558161
Characterization of an inhibitory dynamic pharmacophore for the ERCC1-XPA interaction using a combined molecular dynamics and virtual screening approach.
Journal of molecular graphics & modelling Sep, 2009 | Pubmed ID: 19473860
Electrostatic contributions to colchicine binding within tubulin isotypes.
Electromagnetic biology and medicine , 2009 | Pubmed ID: 20017626
Ensemble-based virtual screening reveals dual-inhibitors for the p53-MDM2/MDMX interactions.
Journal of molecular graphics & modelling Feb, 2010 | Pubmed ID: 20056466
Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping.
Chemistry & biology Jul, 2010 | Pubmed ID: 20659685
Relaxed complex scheme suggests novel inhibitors for the lyase activity of DNA polymerase beta.
Journal of molecular graphics & modelling Feb, 2011 | Pubmed ID: 21194999
Effects of temperature on the p53-DNA binding interactions and their dynamical behavior: comparing the wild type to the R248Q mutant.
PloS one , 2011 | Pubmed ID: 22110706
Discovery of small molecule inhibitors that interact with γ-tubulin.
Chemical biology & drug design May, 2012 | Pubmed ID: 22268380
DNA polymerase beta (pol β) inhibitors: a comprehensive overview.
Drug discovery today Aug, 2012 | Pubmed ID: 22561893
DNA Repair Inhibitors: Our Last Disposal to Improve Cancer Therapy.
Current topics in medicinal chemistry Jun, 2012 | Pubmed ID: 22690684
Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia.
PloS one , 2012 | Pubmed ID: 22761654
DNA repair inhibitors: the next major step to improve cancer therapy.
Current topics in medicinal chemistry , 2012 | Pubmed ID: 22794314
Modeling the yew tree tubulin and a comparison of its interaction with paclitaxel to human tubulin.
Pharmaceutical research Nov, 2012 | Pubmed ID: 22833053
Virtual screening and biological evaluation of inhibitors targeting the XPA-ERCC1 interaction.
PloS one , 2012 | Pubmed ID: 23272099
Small molecule inhibitors of ERCC1-XPF protein-protein interaction synergize alkylating agents in cancer cells.
Molecular pharmacology Jul, 2013 | Pubmed ID: 23580445
A computational model for overcoming drug resistance using selective dual-inhibitors for aurora kinase A and its T217D variant.
Molecular pharmaceutics Dec, 2013 | Pubmed ID: 24094068
Detailed computational study of the active site of the hepatitis C viral RNA polymerase to aid novel drug design.
Journal of chemical information and modeling Nov, 2013 | Pubmed ID: 24116674
Immunomodulatory Function of Interleukin 28B during primary infection with cytomegalovirus.
The Journal of infectious diseases Sep, 2014 | Pubmed ID: 24620020
A Refined Model of the HCV NS5A protein bound to daclatasvir explains drug-resistant mutations and activity against divergent genotypes.
Journal of chemical information and modeling Feb, 2015 | Pubmed ID: 24730573
Vaccine adjuvants--understanding molecular mechanisms to improve vaccines.
Swiss medical weekly , 2014 | Pubmed ID: 24844935
A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity.
Toxicology letters Nov, 2014 | Pubmed ID: 25127758
Human structural proteome-wide characterization of Cyclosporine A targets.
Bioinformatics (Oxford, England) Dec, 2014 | Pubmed ID: 25172926
Thermoplastic vestibuloplasty: a novel technique for treatment of lip and cheek adhesion.
Craniomaxillofacial trauma & reconstruction Dec, 2014 | Pubmed ID: 25383145
IL-28B is a key regulator of B- and T-cell vaccine responses against influenza.
PLoS pathogens Dec, 2014 | Pubmed ID: 25503988
Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA.
Drug discovery today May, 2015 | Pubmed ID: 25622780
Human PD-1 binds differently to its human ligands: a comprehensive modeling study.
Journal of molecular graphics & modelling Apr, 2015 | Pubmed ID: 25723350
Discovery of Novel Peptidomimetics as Irreversible CHIKV NsP2 Protease Inhibitors Using Quantum Mechanical-Based Ligand Descriptors.
Chemical biology & drug design Dec, 2015 | Pubmed ID: 26212366
Entropy in bimolecular simulations: A comprehensive review of atomic fluctuations-based methods.
Journal of molecular graphics & modelling Nov, 2015 | Pubmed ID: 26407139
New design of nucleotide excision repair (NER) inhibitors for combination cancer therapy.
Journal of molecular graphics & modelling Feb, 2016 | Pubmed ID: 26939044
Mohameedyaseen Syedbasha1,
Janina Linnik1,2,3,
Deanna Santer4,
Daire O'Shea5,
Khaled Barakat4,6,
Michael Joyce4,
Nina Khanna7,
D. Lorne Tyrrell4,
Michael Houghton4,
Adrian Egli1,8
1Applied Microbiology Research, Department of Biomedicine, University of Basel,
2Department of Biosystems Science and Engineering, ETH Zurich, and Swiss Institute of Bioinformatics,
3, Swiss Institute of Bioinformatics,
4Li Ka Shing Institute for Virology, University of Alberta,
5Regional Infectious Diseases Unit, University of Edinburgh,
6Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta,
7Infection Biology, Department of Biomedicine, University of Basel,
8Clinical Microbiology, University Hospital Basel
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