Department of Chemical and Systems Biology
Nir Qvit is an Associate Professor in the Faculty of Medicine, Bar-Ilan University, Israel. He received his undergraduate and a Ph.D. in organic chemistry developing different strategies for the synthesis of small molecules and peptides, in solution and on a solid support, for various therapeutic applications from the Hebrew University of Jerusalem, Israel. Dr. Qvit overcame challenging synthesis and developed an innovative procedure for generating novel and highly bioactive protein-protein interaction inhibitors and was awarded the prestigious Kaye Innovation Award for demonstrating extraordinary creativity as a medicinal chemist.
During Dr. Qvit’s training, he developed a keen focus on research that encompasses the maintenance of mitochondrial homeostasis and cell fate. As a post-doctoral fellow (2008 to 2016) in Daria Mochly-Rosen’s lab at the Department of Chemical and System Biology in Stanford School of Medicine, Stanford, CA, USA, He developed and studied the roles of inhibitors that selectively regulates the protein-protein interactions between a kinase and its specific substrate among many, and he developed specific inhibitors of large GTPase to modulate excessive mitochondrial fission. These inhibitors are highly active in models of neurodegenerative disease and cardiovascular disease, and one molecule has been licensed to a biopharmaceutical company.
Dr. Qvit served as a chairman for multiple sessions of several conferences and was the Chair of the first: “Gordon Research Seminar: The Future of Peptides in Chemistry and Biology, 2012”. He received the prestigious Kaye Innovation Award for demonstrating extraordinary creativity as a medicinal chemist, the Burroughs Wellcome Fund Collaborative Research Grant, and the European Molecular Biology Organization (EMBO) Fellowship, and in 2017 he was recruited as faculty at Bar-Ilan University. His research focuses on the development of novel tools to regulate protein-protein interactions in a highly specific manner for basic research and for therapeutic applications.
Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor.
Journal of combinatorial chemistry Mar-Apr, 2008 | Pubmed ID: 18271560
Development of bifunctional photoactivatable benzophenone probes and their application to glycoside substrates.
Biopolymers , 2008 | Pubmed ID: 18459171
Design and synthesis of backbone cyclic phosphorylated peptides: The IkappaB model.
Biopolymers Feb, 2009 | Pubmed ID: 19025995
Rationally designed peptide regulators of protein kinase C.
Trends in endocrinology and metabolism: TEM Jan, 2009 | Pubmed ID: 19056296
Design and synthesis of backbone cyclic phosphopeptides: the IkappaB model.
Advances in experimental medicine and biology , 2009 | Pubmed ID: 19400129
Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure.
Drug discovery today. Disease mechanisms , 2010 | Pubmed ID: 21151743
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
Journal of cell science Feb, 2013 | Pubmed ID: 23239023
Microwave-assisted synthesis of cyclic phosphopeptide on solid support.
Chemical biology & drug design Mar, 2015 | Pubmed ID: 25042903
The many hats of protein kinase Cδ: one enzyme with many functions.
Biochemical Society transactions Dec, 2014 | Pubmed ID: 25399565
Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases.
Circulation research May, 2015 | Pubmed ID: 25999419
Backbone-Cyclized Peptides: A Critical Review.
Current topics in medicinal chemistry , 2018 | Pubmed ID: 29773062
Conversion of Protein Active Regions into Peptidomimetic Therapeutic Leads Using Backbone Cyclization and Cycloscan - How to Do it Yourself!
Current topics in medicinal chemistry , 2018 | Pubmed ID: 29773063
Cyclic Peptides for Protein-Protein Interaction Targets.
Current topics in medicinal chemistry , 2018 | Pubmed ID: 30014801
Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo.
Scientific reports 09, 2018 | Pubmed ID: 30232469
Approach for comparing protein structures and origami models.
Biochimica et biophysica acta. Biomembranes 02, 2020 | Pubmed ID: 31738904
An Approach to comparing protein structures and origami models - Part 2. Multi-domain proteins.
Biochimica et biophysica acta. Biomembranes 11, 2020 | Pubmed ID: 32710853
Natriuretic Peptides as the Basis of Peptide Drug Discovery for Cardiovascular Diseases.
Current topics in medicinal chemistry , 2020 | Pubmed ID: 33050863
Engineering "Antimicrobial Peptides" and Other Peptides to Modulate Protein-Protein Interactions in Cancer.
Current topics in medicinal chemistry , 2020 | Pubmed ID: 33087030
Peptide Therapeutics: Scientific Approaches, Current Development Trends, and Future Directions.
Current topics in medicinal chemistry , 2020 | Pubmed ID: 33297905
A Selective Inhibitor of Cardiac Troponin I Phosphorylation by Delta Protein Kinase C (δPKC) as a Treatment for Ischemia-Reperfusion Injury.
Pharmaceuticals (Basel, Switzerland) Feb, 2022 | Pubmed ID: 35337069
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