Dylan Owen

Bayesian cluster identification in single-molecule localization microscopy data.

Fluorescence lifetime imaging provides enhanced contrast when imaging the phase-sensitive dye di-4-ANEPPDHQ in model membranes and live cells.

Rapid hyperspectral fluorescence lifetime imaging.

The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium.

Optical techniques for imaging membrane lipid microdomains in living cells.

Excitation-resolved hyperspectral fluorescence lifetime imaging using a UV-extended supercontinuum source.

Improved sectioning in a slit scanning confocal microscope.

Three-dimensional molecular mapping in a microfluidic mixing device using fluorescence lifetime imaging.

High-speed high-resolution imaging of intercellular immune synapses using optical tweezers.

A compact, multidimensional spectrofluorometer exploiting supercontinuum generation.

High speed unsupervised fluorescence lifetime imaging confocal multiwell plate reader for high content analysis.

Quantitative microscopy: protein dynamics and membrane organisation.

Lipid order and molecular assemblies in the plasma membrane of eukaryotic cells.

Optimized time-gated generalized polarization imaging of Laurdan and di-4-ANEPPDHQ for membrane order image contrast enhancement.

PALM imaging and cluster analysis of protein heterogeneity at the cell surface.

Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse.

High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells.

Dynamic organization of lymphocyte plasma membrane: lessons from advanced imaging methods.

Imaging membrane lipid order in whole, living vertebrate organisms.

Primary human CD4+ T cells have diverse levels of membrane lipid order that correlate with their function.

Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events.

Quantitative imaging of membrane lipid order in cells and organisms.

Optical techniques for imaging membrane domains in live cells (live-cell palm of protein clustering).

HIV taken by STORM: super-resolution fluorescence microscopy of a viral infection.

Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS.

The lipid raft hypothesis revisited--new insights on raft composition and function from super-resolution fluorescence microscopy.

The Relationship between fenestrations, sieve plates and rafts in liver sinusoidal endothelial cells.

Targeted subendothelial matrix oxidation by myeloperoxidase triggers myosin II-dependent de-adhesion and alters signaling in endothelial cells.

Fluorescence localization microscopy: The transition from concept to biological research tool.

Super-resolution imaging by localization microscopy.

Conformational states of the kinase Lck regulate clustering in early T cell signaling.

Sub-resolution lipid domains exist in the plasma membrane and regulate protein diffusion and distribution.

Protein kinase C controls vesicular transport and secretion of apolipoprotein E from primary human macrophages.

CD317/Tetherin is an organiser of membrane microdomains.

Characterization of a new series of fluorescent probes for imaging membrane order.

Quantitative analysis of three-dimensional fluorescence localization microscopy data.

Superresolution microscopy reveals nanometer-scale reorganization of inhibitory natural killer cell receptors upon activation of NKG2D.

Imaging lipid domains in cell membranes: the advent of super-resolution fluorescence microscopy.

Method for co-cluster analysis in multichannel single-molecule localisation data.

Tropomyosin Tm5NM1 spatially restricts src kinase activity through perturbation of Rab11 vesicle trafficking.

Imaging membrane order using environmentally sensitive fluorophores.

Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.

Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains.

Molecular flow quantified beyond the diffraction limit by spatiotemporal image correlation of structured illumination microscopy data.

Discreet and distinct clustering of five model membrane proteins revealed by single molecule localization microscopy.

Topographic prominence as a method for cluster identification in single-molecule localisation data.

Protein clustering and spatial organization in T-cells.

The nanoscale organization of signaling domains at the plasma membrane.

Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.

Enhancing Quantum Dots for Bioimaging using Advanced Surface Chemistry and Advanced Optical Microscopy: Application to Silicon Quantum Dots (SiQDs).

The aPKC/Par3/Par6 polarity complex and membrane order are functionally inter-dependent in epithelia during vertebrate organogenesis.