Massimo Trucco

Molecular basis of evolutionary loss of the alpha 1,3-galactosyltransferase gene in higher primates.

Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes.

Cellular environment and freedom of gene expression.

Pancreas and islet cell transplantation.

Genes and engineered cells as drugs for type I and type II diabetes mellitus therapy and prevention.

Distinct characteristics and features of allogeneic chimerism in the NOD mouse model of autoimmune diabetes.

Y Chromosomal Sequences Identified in Gonadal Tissue of Two 45,X Patients with Turner Syndrome.

Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound.

Immunosuppressive effects of glucosamine.

Gene therapy strategies to prevent autoimmune disorders.

Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus.

Monocytes are progressively activated in the circulation of pregnant women.

Production of alpha 1,3-galactosyltransferase-deficient pigs.

Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide.

Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes.

Expansion of specific alphabeta+ T-cell subsets in the myocardium of patients with myocarditis and idiopathic dilated cardiomyopathy associated with Coxsackievirus B infection.

Regulation of FasL/Fas in human trophoblasts: possible implications for chorioamnionitis.

Tolerogenic immunosuppression for organ transplantation.

Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes.

Gene therapy technology applied to disorders of glucose metabolism: promise, achievements, and prospects.

Four-color flow cytometric analysis of peripheral blood donor cell chimerism.

Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity.

Flexible management of enzymatic digestion improves human islet isolation outcome from sub-optimal donor pancreata.

Need for genetic education for type 1 diabetes.

Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein.

Current status and prospects for gene and cell therapeutics for type 1 diabetes mellitus.

HLA class II DRB high resolution genotyping by pyrosequencing: comparison of group specific PCR and pyrosequencing primers.

Islet/pancreas transplantation: challenges for pediatrics.

Lessons of organ-induced tolerance learned from historical clinical experience.

Islet cell autoimmunity in a triethnic adult population of the Third National Health and Nutrition Examination Survey.

Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells.

Response of human islets to isolation stress and the effect of antioxidant treatment.

Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans.

Stem cells and diabetes.

Regeneration of the pancreatic beta cell.

SOP3: a web-based tool for selection of oligonucleotide primers for single nucleotide polymorphism analysis by Pyrosequencing.

Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice.

Footer: a quantitative comparative genomics method for efficient recognition of cis-regulatory elements.

SOP3v2: web-based selection of oligonucleotide primer trios for genotyping of human and mouse polymorphisms.

Harmful delayed effects of exogenous isolation enzymes on isolated human islets: relevance to clinical transplantation.

Gene therapy for type 1 diabetes: a proposal to move to the next level.

Gene therapy for type 1 diabetes.

A look to the future: prediction, prevention, and cure including islet transplantation and stem cell therapy.

Multifaceted therapeutic approaches for a multigenic disease.

Facilitating physiologic self-regeneration: a step beyond islet cell replacement.

Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells.

Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies.

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.

Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes.

Is facilitating pancreatic beta cell regeneration a valid option for clinical therapy?

Rehabilitation of adaptive immunity and regeneration of beta cells.

Induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: adverse effects and early responses.

Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice.

Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibility.

Web-based primer design software for genome-scale genotyping by pyrosequencing.

Pyrosequencing-based strategies for improved allele typing of human leukocyte antigen loci.

Functionally important glycosyltransferase gain and loss during catarrhine primate emergence.

Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness.

Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies.

Reduction of early graft loss after intraportal porcine islet transplantation in monkeys.

To be DR8 or not to be DQ8, that is the question.

Suppression of memory CD8 T cell generation and function by tryptophan catabolism.

Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.

Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels.

Immunoregulatory dendritic cells to prevent and reverse new-onset Type 1 diabetes mellitus.

Immunomodulation by adenoviral-mediated SCD40-Ig gene therapy for mouse allogeneic islet transplantation.

Increased Expression of Monocyte CD11b (Mac-1) in Overweight Recent-Onset Type 1 Diabetic Children.

Navigating pathways affecting type 1 diabetic kidney disease.

Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival.

Induction of immune tolerance to facilitate beta cell regeneration in type 1 diabetes.

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.

On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.

Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-kappaB activation in vascular smooth muscle cells.

A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes.

Identification of novel IGRP epitopes targeted in type 1 diabetes patients.

Renal diseases as targets of gene therapy.

Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond.

Dendritic cell mediated therapy for immunoregulation of type 1 diabetes mellitus.

AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice.

Proteomic analysis of fructose-induced fatty liver in hamsters.

The role of external and matrix pH in mitochondrial reactive oxygen species generation.

Multiplex HLA-typing by pyrosequencing.

Recovery of endogenous beta-cell function in nonhuman primates after chemical diabetes induction and islet transplantation.

Suppression of autoimmune diabetes by soluble galectin-1.

Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.

Thymus-specific deletion of insulin induces autoimmune diabetes.

Breakthrough in diabetes therapy ... Just around the corner?

Anti-inflammatory properties of C-Peptide.

Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia.

Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells.

Screen and clean: a tool for identifying interactions in genome-wide association studies.

Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes.

Redox modulation protects islets from transplant-related injury.

Dendritic cell-based therapy in Type 1 diabetes mellitus.

Gene-environment interaction in type 1 diabetes mellitus.

Gene-environment interaction in type 1 diabetes mellitus.

Beta-cell regeneration: from science fiction to challenging reality.

Regenerative medicine for diabetes treatment.

Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies.

Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases.

HLA matching and the point system.

Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.

Phosphatidylinositol-3-kinase activity during in vitro dendritic cell generation determines suppressive or stimulatory capacity.

Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain.

Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation.

The Role of Cell Migration and Chimerism in Organ Transplant Acceptance and Tolerance Induction.

Kidney/Bone Marrow Transplantation.

Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients.

A multivalent vaccine for type 1 diabetes skews T cell subsets to Th2 phenotype in NOD mice.

Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same?

Pig-to-nonhuman primates pancreatic islet xenotransplantation: an overview.

Immunotherapy-based strategies for the treatment of autoimmune diabetes: searching for the cure.

C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia.

Clinical xenotransplantation: the next medical revolution?

An improved intracellular staining protocol for efficient detection of nuclear proteins in YFP-expressing cells.

Essential roles of insulin expression in Aire+ tolerogenic dendritic cells in maintaining peripheral self-tolerance of islet β-cells.

Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression.

Isolation of human islets for autologous islet transplantation in children and adolescents with chronic pancreatitis.

FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival.

Modulation of redox balance leaves murine diabetogenic TH1 T cells "LAG-3-ing" behind.

Cytokine and chemokine production by human pancreatic islets upon enterovirus infection.

A role for tolerogenic dendritic cell-induced B-regulatory cells in type 1 diabetes mellitus.

Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated?

Multistationary and oscillatory modes of free radicals generation by the mitochondrial respiratory chain revealed by a bifurcation analysis.

Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and β cell regeneration in a T1D model.

Dendritic cell therapy for Type 1 diabetes suppression.

Clinical islet xenotransplantation: how close are we?

Increased yield and improved transplantation outcome of mouse islets with bovine serum albumin.

Toward clinical islet xenotransplantation - are revisions to the IXA guidelines warranted?

Intestinal γδ T-cell lymphomas are most frequently of type II enteropathy-associated T-cell type.

Clustering and alignment of polymorphic sequences for HLA-DRB1 genotyping.

Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells.

In vivo delivery of nucleic acid-formulated microparticles as a potential tolerogenic vaccine for type 1 diabetes.

The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation.

Islet xenotransplantation from genetically engineered pigs.

It's time to bring dendritic cell therapy to type 1 diabetes.

Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice.

Compromised central tolerance of ICA69 induces multiple organ autoimmunity.

Islet xenotransplantation: what is the optimal age of the islet-source pig?

Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.

Obesity, islet cell autoimmunity, and cardiovascular risk factors in youth at onset of type 1 autoimmune diabetes.

Streptozotocin-associated lymphopenia in cynomolgus monkeys.

Glucose metabolism in pigs expressing human genes under an insulin promoter.

Neuronal T-cell autoreactivity is amplified in overweight children with new-onset insulin-requiring diabetes.

Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice.

Cellular therapies based on stem cells and their insulin-producing surrogates: a 2015 reality check.

Generation of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of antigen in the formulation.

Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilizing off-site islet isolation: Cleveland Clinic experience.

Bioengineering mini functional thymic units with EAK16-II/EAKIIH6 self-assembling hydrogel.

A brief glimpse over the horizon for type 1 diabetes nanotherapeutics.

Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts.

Clinical implementation of islet transplantation: A current assessment.

Author Response to Letter by Delibasi T., et al.

In vitro exposure of pig neonatal isletlike cell clusters to human blood.

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation.

Use of genetically-engineered pig donors in islet transplantation.

A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation.

Inherent ER stress in pancreatic islet β cells causes self-recognition by autoreactive T cells in type 1 diabetes.