Thomas Douglas

Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms.

Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite.

A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species.

Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide.

Ingress and reactive chemistry of nitroxyl-derived species within human cells.

Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction.

Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems.

Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS.

Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.

A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system.

Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation.

Viral-associated trichodysplasia in patients who are immunocompromised.

The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations.

Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide.

The chemical dynamics of NO and reactive nitrogen oxides: a practical guide.

Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH.

Pili trianguli et canaliculi is a defect of inner root sheath keratinization: ultrastructural observations of anomalous tonofilament organization in a case.

Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1.

Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients.

Discriminating formation of HNO from other reactive nitrogen oxide species.

Superoxide fluxes limit nitric oxide-induced signaling.

Phosphine-olefin ligands: a facile dehydrogenative route to catalytically active rhodium complexes.

The biphasic nature of nitric oxide responses in tumor biology.

The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling.

Peroxynitrite and myocardial contractility: in vivo versus in vitro effects.

Inflammation and IGF-I activate the Akt pathway in breast cancer.

The role of halogenated carborane monoanions in olefin hydrogenation catalysed by cationic iridium phosphine complexes.

Asbestos redirects nitric oxide signaling through rapid catalytic conversion to nitrite.

Phylogenetic analysis of bacteria preserved in a permafrost ice wedge for 25,000 years.

Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways.

Intramolecular alkyl phosphine dehydrogenation in cationic rhodium complexes of tris(cyclopentylphosphine).

Reversible addition of water to the high-hydride-content cluster [Rh6(PiPr3)6H12][BArF4]2. Synthesis and Structure of [Rh6PiPr3)6H11(OH)][BArF4]2.

The chemical biology of nitric oxide: implications in cellular signaling.

Influence of snow and ice crystal formation and accumulation on mercury deposition to the Arctic.

Molecular mechanisms for discrete nitric oxide levels in cancer.

Amine-borane sigma-complexes of rhodium. relevance to the catalytic dehydrogenation of amine-boranes.

Consequentialism and the death penalty.

Medical injury compensation: beyond 'no-fault'.

Moral Enhancement.

Glaciibacter superstes gen. nov., sp. nov., a novel member of the family Microbacteriaceae isolated from a permafrost ice wedge.

A time series investigation of the stability of nitramine and nitroaromatic explosives in surface water samples at ambient temperature.

Destroying unwanted embryos in research. Talking Point on morality and human embryo research.

Comparing the chemical biology of NO and HNO.

Enhancement in Sport, and Enhancement outside Sport.

Monomeric and oligomeric amine-borane sigma-complexes of rhodium. intermediates in the catalytic dehydrogenation of amine-boranes.

Absence of significant dissent should be sufficient for deceased donor organ procurement in New Zealand.

Investigating the fate of nitroaromatic (TNT) and nitramine (RDX and HMX) explosives in fractured and pristine soils.

Tomitella biformata gen. nov., sp. nov., a new member of the suborder Corynebacterineae isolated from a permafrost ice wedge.

Nitric oxide and cancer therapy: the emperor has NO clothes.

Resisting Sparrow's sexy reductio: selection principles and the social good.

Australian attitudes to early and late abortion.

Synthetic biology and the ethics of knowledge.

Desorption of nitramine and nitroaromatic explosive residues from soils detonated under controlled conditions.

SHOULD INSTITUTIONS PRIORITIZE RECTIFICATION OVER AID?

Intertemporal Disagreement and Empirical Slippery Slope Arguments.

Dissolution and sorption of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and 2,4,6-trinitrotoluene (TNT) residues from detonated mineral surfaces.

Dinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance.

Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron.

Moral enhancement via direct emotion modulation: a reply to John Harris.

Self-serving bias and the structure of moral status.

Is S-nitrosocysteine a true surrogate for nitric oxide?

Is NICE ageist? Highlights from this issue.

S-nitrosation: current concepts and new developments.

Engineering and ethical perspectives in synthetic biology. Rigorous, robust and predictable designs, public engagement and a modern ethical framework are vital to the continued success of synthetic biology.

The harms of status enhancement could be compensated or outweighed: a response to Agar.

A concise argument: on the wrongness of killing.

Procreative beneficence and in vitro gametogenesis.

Biosecurity and the division of cognitive labour.

Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases.

Human enhancement and supra-personal moral status.

Is the creation of artificial life morally significant?

Coercion, incarceration, and chemical castration: an argument from autonomy.

Procreative altruism: beyond individualism in reproductive selection.

Oxygen dependence of nitric oxide-mediated signaling.

Regulation of devices for cognitive enhancement.

Convective forcing of mercury and ozone in the Arctic boundary layer induced by leads in sea ice.

Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury.

Enhancing Moral Conformity and Enhancing Moral Worth.

Stocking the genetic supermarket: reproductive genetic technologies and collective action problems.

Moral bioenhancement, freedom and reasoning.

Enhancement and Civic Virtue.

The Relationship Between Effort and Moral Worth: Three Amendments to Sorensen's Model.

The compromise of macrophage functions by hyperoxia is attenuated by ethacrynic acid via inhibition of NF-κB-mediated release of high-mobility group box-1.

Criminal Rehabilitation Through Medical Intervention: Moral Liability and the Right to Bodily Integrity.

Insights into the diverse effects of nitric oxide on tumor biology.

The regulation of cognitive enhancement devices: extending the medical model.

Stem cell-derived gametes, iterated in vitro reproduction, and genetic parenthood.

The dual-use problem, scientific isolationism and the division of moral labour.

The harms of enhancement and the conclusive reasons view.

The dual-use problem, scientific isolationism and the division of moral labour.

Are You Morally Modified?: The Moral Effects of Widely Used Pharmaceuticals.

Proximity of arteries to the anterior ulna with changing flexion.

Breathing new life into nitric oxide signaling: A brief overview of the interplay between oxygen and nitric oxide.

Sex Offenders Seeking Treatment for Sexual Dysfunction--Ethics, Medicine, and the Law.

The moral imperative to continue gene editing research on human embryos.

Signaling and stress: The redox landscape in NOS2 biology.

Substituted judgment, procreative beneficence, and the Ashley treatment.

Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications.

CRISPR: A path through the thicket.

Genome Editing Technologies and Human Germline Genetic Modification: The Hinxton Group Consensus Statement.

Methadone for prisoners.

Why is Cognitive Enhancement Deemed Unacceptable? The Role of Fairness, Deservingness, and Hollow Achievements.

Duties to rescue: individual, professional and institutional.

Ascorbic Acid Attenuates Hyperoxia-Compromised Host Defense Against Pulmonary Bacterial Infection.