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Department of Biomedical Engineering
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Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2007 | Pubmed ID: 17984060
Subunit-specific effect of the voltage sensor domain on Ca2+ sensitivity of BK channels.
Biophysical journal Jun, 2008 | Pubmed ID: 18339745
Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains.
Nature structural & molecular biology Nov, 2008 | Pubmed ID: 18931675
State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation.
The Journal of general physiology Jun, 2010 | Pubmed ID: 20479111
An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.
Neuron Jun, 2010 | Pubmed ID: 20620873
KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function.
Biophysical journal Dec, 2010 | Pubmed ID: 21112284
Washington University in St. Louis
Junqiu Yang1,
Kelli Delaloye2,
Urvi S. Lee2,
Jianmin Cui3
1Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis,
2Department of Biomedical Engineering, Washington University in St. Louis,
3Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis
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