Steven Dow

Strain-based genetic differences regulate the efficiency of systemic gene delivery as well as expression.

Enhancing antimelanoma immune responses through apoptosis.

Growth inhibition of an orthotopic glioblastoma in immunocompetent mice by cationic lipid-DNA complexes.

Use of immunostimulatory liposome-nucleic acid complexes in allergen-specific immunotherapy of dogs with refractory atopic dermatitis - a pilot study.

Type I interferons potently suppress gene expression following gene delivery using liposome(-)DNA complexes.

Phase I study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases.

Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein.

Early interaction of Yersinia pestis with APCs in the lung.

Francisella tularensis induces aberrant activation of pulmonary dendritic cells.

Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes.

Effects of chemotherapy on immune responses in dogs with cancer.

When the leader has a group in a difficult situation.

Use of flow cytometry and monochlorobimane to quantitate intracellular glutathione concentrations in feline leukocytes.

Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes.

A modified tyrosinase-related protein 2 epitope generates high-affinity tumor-specific T cells but does not mediate therapeutic efficacy in an intradermal tumor model.

Evaluation of a novel immunotherapy for treatment of chronic rhinitis in cats.

Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines.

Evaluation of liposomal clodronate in experimental spontaneous autoimmune hemolytic anemia in dogs.

Evaluation of a novel tumor vaccine in dogs with hemangiosarcoma.

Sustained generation of tissue dendritic cells from cats using organ stromal cell cultures.

Evaluation of a xenogeneic VEGF vaccine in dogs with soft tissue sarcoma.

Continuous low-dose oral chemotherapy for adjuvant therapy of splenic hemangiosarcoma in dogs.

Neutrophil function in septic dogs.

Oxidative stress during acute FIV infection in cats.

Liposome-nucleic acid immunotherapeutics.

Immunoproteomic identification of bovine pericardium xenoantigens.

Prophylaxis with cationic liposome-DNA complexes protects hamsters from phleboviral disease: importance of liposomal delivery and CpG motifs.

Protection from pneumonic infection with burkholderia species by inhalational immunotherapy.

Lung environment determines unique phenotype of alveolar macrophages.

Mucosal immunotherapy for protection from pneumonic infection with Francisella tularensis.

Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation.

Chronic bacterial osteomyelitis suppression of tumor growth requires innate immune responses.

Evaluation of liposomal clodronate for treatment of malignant histiocytosis in dogs.

Molecular basis of rare aminoglycoside susceptibility and pathogenesis of Burkholderia pseudomallei clinical isolates from Thailand.

Type I interferons inhibit the generation of tumor-associated macrophages.

Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection.

Immunotherapy markedly increases the effectiveness of antimicrobial therapy for treatment of Burkholderia pseudomallei infection.

Present and future therapeutic strategies for melioidosis and glanders.

Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols.

How companion animals contribute to the fight against cancer in humans.

A Burkholderia pseudomallei deltapurM mutant is avirulent in immunocompetent and immunodeficient animals: candidate strain for exclusion from select-agent lists.

Serum concentrations of monocyte chemoattractant protein-1 in healthy and critically ill dogs.

Liposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures.

Protection against pneumonic plague following oral immunization with a non-replicating vaccine.

Minimally invasive assessment of tumor angiogenesis by fine needle aspiration and flow cytometry.

Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensis.

Evaluation of intrarenal mesenchymal stem cell injection for treatment of chronic kidney disease in cats: a pilot study.

Mucosal immunization with liposome-nucleic acid adjuvants generates effective humoral and cellular immunity.

The Burkholderia pseudomallei Δasd mutant exhibits attenuated intracellular infectivity and imparts protection against acute inhalation melioidosis in mice.

MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection.

Consumption of Rice Bran Increases Mucosal Immunoglobulin A Concentrations and Numbers of Intestinal Lactobacillus spp.

In vitro comparison of feline bone marrow-derived and adipose tissue-derived mesenchymal stem cells.

Elevated interleukin 6 activity in aqueous humor of cats with uveitis.

In vivo monocyte tropism of pathogenic feline immunodeficiency viruses.

Clinical evaluation of a single dose of immune plasma for treatment of canine parvovirus infection.

Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections.

Liposomal clodronate treatment for tumour macrophage depletion in dogs with soft-tissue sarcoma.

Dietary rice bran promotes resistance to Salmonella enterica serovar Typhimurium colonization in mice.

Persistent gastric colonization with Burkholderia pseudomallei and dissemination from the gastrointestinal tract following mucosal inoculation of mice.

Post-exposure immunization against Francisella tularensis membrane proteins augments protective efficacy of gentamicin in a mouse model of pneumonic tularemia.

Incunabular immunological events in prion trafficking.

Burkholderia pseudomallei known siderophores and hemin uptake are dispensable for lethal murine melioidosis.

Urinary cytokine levels in apparently healthy cats and cats with chronic kidney disease.

Suppression of vaccine immunity by inflammatory monocytes.

Depletion of phagocytic myeloid cells triggers spontaneous T cell- and NK cell-dependent antitumor activity.

Optimized dosing of a CCR2 antagonist for amplification of vaccine immunity.

Development of Burkholderia mallei and pseudomallei vaccines.

Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three sequential pilot studies.

An improved selective culture medium enhances the isolation of Burkholderia pseudomallei from contaminated specimens.

Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine.

Protective response to subunit vaccination against intranasal and challenge.

Optimization of murine small intestine leukocyte isolation for global immune phenotype analysis.

Comparison of 3 real-time, quantitative murine models of staphylococcal biofilm infection by using in vivo bioluminescent imaging.

Blocking phosphatidylcholine utilization in Pseudomonas aeruginosa, via mutagenesis of fatty acid, glycerol and choline degradation pathways, confirms the importance of this nutrient source in vivo.

Interaction of Interferon gamma-induced reactive oxygen species with ceftazidime leads to synergistic killing of intracellular Burkholderia pseudomallei.

Comparison of cancer stem cell antigen expression by tumor cell lines and by tumor biopsies from dogs with melanoma and osteosarcoma.

Long-term evaluation of mesenchymal stem cell therapy in a feline model of chronic allergic asthma.

Intravenous adipose-derived mesenchymal stem cell therapy for the treatment of feline asthma: a pilot study.

Cancer immunotherapy in veterinary medicine: Current options and new developments.

Concise Review: Stem Cell Trials Using Companion Animal Disease Models.

Comparison of cytokine responses between dogs with sepsis and dogs with immune-mediated hemolytic anemia.

Suppression of Canine Dendritic Cell Activation/Maturation and Inflammatory Cytokine Release by Mesenchymal Stem Cells Occurs Through Multiple Distinct Biochemical Pathways.

Mechanisms of Immune Suppression Utilized by Canine Adipose and Bone Marrow-Derived Mesenchymal Stem Cells.

Autologous and Allogeneic Equine Mesenchymal Stem Cells Exhibit Equivalent Immunomodulatory Properties In Vitro.

Regulation of PD-L1 expression on murine tumor-associated monocytes and macrophages by locally produced TNF-α.

Activated Mesenchymal Stem Cells Interact with Antibiotics and Host Innate Immune Responses to Control Chronic Bacterial Infections.

Manipulation of Innate Immunity for Cancer Therapy in Dogs.

Immunization against full-length protein and peptides from the Lutzomyia longipalpis sand fly salivary component maxadilan protects against Leishmania major infection in a murine model.

Safety and immune regulatory properties of canine induced pluripotent stem cell-derived mesenchymal stem cells.

Mesenchymal Stem Cells Recruit CCR2 Monocytes To Suppress Allergic Airway Inflammation.

Mesenchymal Stem Cells (MSC) Derived from Induced Pluripotent Stem Cells (iPSC) Equivalent to Adipose-Derived MSC in Promoting Intestinal Healing and Microbiome Normalization in Mouse Inflammatory Bowel Disease Model.

Programmed Cell Death Ligand 1 (PD-L1) Signaling Regulates Macrophage Proliferation and Activation.

Validation of a clinically applicable flow cytometric assay for the detection of immunoglobulin associated platelets in dogs.

Evaluation of immunological parameters in pit bull terrier-type dogs with juvenile onset generalized demodicosis and age-matched healthy pit bull terrier-type dogs.

Induction of Synovitis Using Interleukin-1 Beta: Are There Differences in the Response of Middle Carpal Joint Compared to the Tibiotarsal Joint?

Cancer stem cell populations in lymphoma in dogs and impact of cytotoxic chemotherapy.

Activation of upper respiratory tract mucosal innate immune responses in cats by liposomal toll-like receptor ligand complexes delivered topically.

Evaluation of liposome toll-like receptor ligand complexes for non-specific mucosal immunoprotection from feline herpesvirus-1 infection.

Evaluation of Intravenously Delivered Allogeneic Mesenchymal Stem Cells for Treatment of Elbow Osteoarthritis in Dogs: A Pilot Study.

The Angiotensin Receptor Blocker Losartan Suppresses Growth of Pulmonary Metastases via AT1R-Independent Inhibition of CCR2 Signaling and Monocyte Recruitment.

PrPC knockdown by liposome-siRNA-peptide complexes (LSPCs) prolongs survival and normal behavior of prion-infected mice immunotolerant to treatment.

Humoral immune responses against gut bacteria in dogs with inflammatory bowel disease.

Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs.

Antibacterial activity of human mesenchymal stem cells mediated directly by constitutively secreted factors and indirectly by activation of innate immune effector cells.

Single and repeated intra-articular injections in the tarsocrural joint with allogeneic and autologous equine bone marrow-derived mesenchymal stem cells are safe, but did not reduce acute inflammation in an experimental interleukin-1β model of synovitis.

Mesenchymal stem cells for treatment of musculoskeletal disease in horses: Relative merits of allogeneic versus autologous stem cells.

Amikacin induces rapid dose-dependent apoptotic cell death in equine chondrocytes and synovial cells in vitro.

A Role for Dogs in Advancing Cancer Immunotherapy Research.

Detection and dynamics of anti-platelet antibodies in thrombocytopenic dogs with and without idiopathic immune thrombocytopenia.

Pretreatment aerobic bacterial swab cultures to predict infection in acute open traumatic wounds: A prospective clinical study of 64 dogs.

Use of in vitro assays to identify antibiotics that are cytotoxic to normal equine chondrocytes and synovial cells.

Non-specific protection from respiratory tract infections in cattle generated by intranasal administration of an innate immune stimulant.

Clinical evaluation of hyperimmune plasma for treatment of dogs with naturally occurring parvoviral enteritis.

Generation of Neural Progenitor Cells From Canine Induced Pluripotent Stem Cells and Preliminary Safety Test in Dogs With Spontaneous Spinal Cord Injuries.

Optimizing In Vitro Osteogenesis in Canine Autologous and Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells with Dexamethasone and BMP-2.

Veterinary Cooperative Oncology Group-Common Terminology Criteria for Adverse Events (VCOG-CTCAE v2) following investigational therapy in dogs and cats.

Susceptibility of canine chondrocytes and synoviocytes to antibiotic cytotoxicity in vitro.

Toll-like receptor activation of equine mesenchymal stromal cells to enhance antibacterial activity and immunomodulatory cytokine secretion.

Impact of Three Different Serum Sources on Functional Properties of Equine Mesenchymal Stromal Cells.

Evaluation of Intra-Articular Amikacin Administration in an Equine Non-inflammatory Joint Model to Identify Effective Bactericidal Concentrations While Minimizing Cytotoxicity.

Enthesis trauma as a means for the development of translatable chronic rotator cuff degeneration in an ovine model.

Intra-articular administration of antibiotics in horses: Justifications, risks, reconsideration of use and outcomes.

Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma.

Therapeutic Intervention Using a Smad7-Based Tat Protein to Treat Radiation-Induced Oral Mucositis.

Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses.

Tendon midsubstance trauma as a means for the development of translatable chronic rotator cuff degeneration in an ovine model.

Immunologic Effects of Stereotactic Body Radiotherapy in Dogs with Spontaneous Tumors and the Impact of Intratumoral OX40/TLR Agonist Immunotherapy.

Intra-Articular Injections of Allogeneic Mesenchymal Stromal Cells vs. High Molecular Weight Hyaluronic Acid in Dogs With Osteoarthritis: Exploratory Data From a Double-Blind, Randomized, Prospective Clinical Trial.

Activated Mesenchymal Stromal Cell Therapy for Treatment of Multi-Drug Resistant Bacterial Infections in Dogs.

Intravenous injection of adipose-derived mesenchymal stromal cells benefits gait and inflammation in a spontaneous osteoarthritis model.

In Vitro Anti-Inflammatory and Regenerative Effects of Autologous Conditioned Serum from Dogs with Osteoarthritis.

Immune Activated Cellular Therapy for Drug Resistant Infections: Rationale, Mechanisms, and Implications for Veterinary Medicine.

Novel ocular immunotherapy induces tumor regression in an equine model of ocular surface squamous neoplasia.

Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors.

Canine polarized macrophages express distinct functional and transcriptomic profiles.

TLR-activated mesenchymal stromal cell therapy and antibiotics to treat multi-drug resistant septic arthritis in an equine model.

Nanoparticle ocular immunotherapy for herpesvirus surface eye infections evaluated in cat infection model.

Reprogramming the Canine Glioma Microenvironment with Tumor Vaccination plus Oral Losartan and Propranolol Induces Objective Responses.

Editorial: Canine melanoma in comparative oncology: Translate research advances to develop new diagnostic and therapeutic options.

Distinct differences in immunological properties of equine orthobiologics revealed by functional and transcriptomic analysis using an activated macrophage readout system.

Chronic adrenergic stress and generation of myeloid-derived suppressor cells: Implications for cancer immunotherapy in dogs.

Strategies to overcome myeloid cell induced immune suppression in the tumor microenvironment.

Evaluation of Immune Nanoparticles for Rapid and Non-Specific Activation of Antiviral and Antibacterial Immune Responses in Cattle, Swine, and Poultry.

A single-cell RNA sequencing atlas of circulating leukocytes from healthy and osteosarcoma affected dogs.

Erythrocyte removal from bone marrow aspirate concentrate improves efficacy as intra-articular cellular therapy in a rodent osteoarthritis model.

Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions.

Single-cell RNA sequencing reveals the cellular and molecular heterogeneity of treatment-naïve primary osteosarcoma in dogs.

Efficacy of an elemental diet in achieving clinical remission in dogs with chronic enteropathy.

Modulation of In Vitro Macrophage Responses via Primary and Secondary Bile Acids in Dogs.

Preliminary evaluation of safety and migration of immune activated mesenchymal stromal cells administered by subconjunctival injection for equine recurrent uveitis.

Direct comparison of canine and human immune responses using transcriptomic and functional analyses.

Targeted transcriptomic analysis of synovial tissues from horses with septic arthritis treated with immune-activated mesenchymal stromal cells reveals induction of T-cell response pathways.

Intralesional interferon alpha-2b as a novel treatment for periocular squamous cell carcinoma in horses.

Review of cellular therapies provides new insights into the potential treatment of diverse neurologic diseases in horses and dogs.

Targeting osteosarcoma with canine B7-H3 CAR T cells and impact of CXCR2 Co-expression on functional activity.

Single-cell RNA sequencing reveals the cellular and molecular heterogeneity of treatment-naïve primary osteosarcoma in dogs.

Impact of Equine Ocular Surface Squamous Neoplasia on Interactions between Ocular Transcriptome and Microbiome.

Immunohistochemical and transcriptomic characterization of T and myeloid cell infiltrates in canine malignant melanoma.

Evaluation of stem-cell therapies in companion animal disease models: a concise review (2015-2023).

Immunization against nucleus pulposus antigens to accelerate degenerative disc disease in a rabbit model.

The potential for senotherapy as a novel approach to extend life quality in veterinary medicine.

Single cell transcriptomic analysis of the canine duodenum in chronic inflammatory enteropathy and health.

Comparison of Antiviral Immune Responses in Healthy Cats Induced by Two Immune Therapeutics.

Host-microbe interactions in the nasal cavity of dogs with chronic idiopathic rhinitis.

Author Correction: Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors.

Characterization of the single cell landscape in normal and osteoarthritic equine joints.

A Pilot Study to Assess the Safety and Efficacy of Umbilical Cord Blood-Derived Mesenchymal Stromal Cells for the Treatment of Synovitis in Horses.