Arie Horowitz
Department of Medicine,
Cardeza Vascular Research Center,
Department of Cancer Biology,
Department of Medicine, Cardeza Vascular Research Center,
Department of Cancer Biology, Cardeza Vascular Research Center
Sidney Kimmel Medical College, Thomas Jefferson University
Dr. Arie Horowitz is an associate professor at the Cardeza Center for Vascular Biology Research at the Sydney Kimmel Medical College of Thomas Jefferson University. He holds a secondary appointment in the Department of Cancer Biology at the same college. The focus of the Horowitz laboratory is on vascular biology in general and on the molecular mechanisms that regulate vascular permeability in particular. The laboratory uses cell culture and mouse models to understand the homeostasis of the junctions between endothelial cells and their response to factors that disrupt them. He has addressed recently also the underlying pathophysiological and molecular mechanisms of congenital hydrocephalus. His research has been supported by grants from the National Hear Lung and Blood institute, and from the American Heart Association. He published close to fifty peer-reviewed original research and review articles, as well as editorials and book chapters.
Dr. Horowitz received his M.Sc. and D.Sc. degrees in bioengineering at the Israel Institute of Technology. He joined the Thomas Jefferson University faculty in late 2015, after holding faculty positions at the Dartmouth College School of Medicine and the Lerner Research Institute of the Cleveland Clinic. In addition to research, Dr. Horowitz teaches graduate and medical school students.
RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms.
Science signaling Jul, 2016 | Pubmed ID: 27460990
Protein kinase C (PKC) delta regulates PKCalpha activity in a Syndecan-4-dependent manner.
The Journal of biological chemistry Jun, 2002 | Pubmed ID: 11916978
Fibroblast growth factor-specific modulation of cellular response by syndecan-4.
The Journal of cell biology May, 2002 | Pubmed ID: 12011116
A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype.
Molecular biology of the cell Apr, 2006 | Pubmed ID: 16467373
Selective regulation of arterial branching morphogenesis by synectin.
Developmental cell Jun, 2006 | Pubmed ID: 16740480
Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2006 | Pubmed ID: 16908842
Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways.
Circulation research Sep, 2008 | Pubmed ID: 18723443
Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo.
Circulation research Sep, 2008 | Pubmed ID: 18757825
Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion.
The international journal of biochemistry & cell biology Apr, 2009 | Pubmed ID: 18775505
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.
Blood Jan, 2009 | Pubmed ID: 18824598
Branching morphogenesis.
Circulation research Oct, 2008 | Pubmed ID: 18845818
Branching morphogenesis.
Circulation research Jan, 2009 | Pubmed ID: 19179661
Imaging of growth factor-augmented angiogenesis after myocardial infarction: glimmers of a spatiotemporal pattern?
Journal of molecular and cellular cardiology Jun, 2010 | Pubmed ID: 19913025
Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.
The Journal of biological chemistry Jul, 2011 | Pubmed ID: 21543326
Membrane traffic as a coordinator of cell migration and junction remodeling.
Communicative & integrative biology Nov, 2011 | Pubmed ID: 22446532
Regulation of VEGF signaling by membrane traffic.
Cellular signalling Sep, 2012 | Pubmed ID: 22617029
Stimulus-dependent phosphorylation of profilin-1 in angiogenesis.
Nature cell biology Oct, 2012 | Pubmed ID: 23000962
VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx.
The Journal of cell biology Dec, 2012 | Pubmed ID: 23253477
The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover.
FEBS letters Nov, 2013 | Pubmed ID: 24021649
The versatility of RhoA activities in neural differentiation.
Small GTPases Jan, 2017 | Pubmed ID: 28125332
Letter by Horowitz Regarding Article, "Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability".
Circulation research Mar, 2017 | Pubmed ID: 28254807
Analysis of Retinoic Acid-induced Neural Differentiation of Mouse Embryonic Stem Cells in Two and Three-dimensional Embryoid Bodies
1Department of Medicine, Cardeza Vascular Research Center, Sidney Kimmel Medical College, Thomas Jefferson University,
2Department of Molecular Cardiology, Cleveland Clinic Foundation,
3Department of Cancer Biology, Cardeza Vascular Research Center, Sidney Kimmel Medical College, Thomas Jefferson University
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