CarMeN Laboratory,
INSERM U1060,
INRA 1397,
CarMeN Laboratory, INSERM U1060, INRA 1397
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Sterol regulatory element-binding protein-1 mediates the effect of insulin on hexokinase II gene expression in human muscle cells.
Diabetes Feb, 2004 | Pubmed ID: 14747281
Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues.
Journal of lipid research Apr, 2005 | Pubmed ID: 15627654
BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase.
The Journal of biological chemistry Feb, 2006 | Pubmed ID: 16326698
Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs.
The Biochemical journal Nov, 2006 | Pubmed ID: 16831124
Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle.
Physiological genomics Aug, 2008 | Pubmed ID: 18559965
The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway.
Diabetes Nov, 2009 | Pubmed ID: 19720801
A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation.
Molecular and cellular biology Mar, 2010 | Pubmed ID: 20028734
Evidence for mitochondrial respiratory deficiency in rat rhabdomyosarcoma cells.
PloS one , 2010 | Pubmed ID: 20072609
Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia.
American journal of physiology. Regulatory, integrative and comparative physiology Jun, 2010 | Pubmed ID: 20237300
Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis.
PloS one Jun, 2010 | Pubmed ID: 20544018
FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.
Diabetes Jan, 2011 | Pubmed ID: 20943749
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
Cell metabolism Apr, 2011 | Pubmed ID: 21459323
Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.
The Journal of biological chemistry Jun, 2011 | Pubmed ID: 21525000
GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia.
The Journal of clinical endocrinology and metabolism Oct, 2011 | Pubmed ID: 21816778
TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism.
Skeletal muscle Jan, 2012 | Pubmed ID: 22257771
Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle.
PloS one , 2012 | Pubmed ID: 22984430
SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors.
PloS one , 2012 | Pubmed ID: 23226416
Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux.
Arteriosclerosis, thrombosis, and vascular biology Aug, 2013 | Pubmed ID: 23788762
Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations.
The American journal of clinical nutrition Sep, 2013 | Pubmed ID: 23902784
Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling.
Cell communication and signaling : CCS Aug, 2013 | Pubmed ID: 23915343
Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.
Diabetes Nov, 2013 | Pubmed ID: 23919961
A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
Nature medicine Oct, 2013 | Pubmed ID: 24037094
Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation.
Cell cycle (Georgetown, Tex.) , 2014 | Pubmed ID: 24196440
An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site.
American journal of human genetics Jan, 2014 | Pubmed ID: 24387992
Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?
PloS one , 2014 | Pubmed ID: 24392111
Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice.
Diabetologia Oct, 2014 | Pubmed ID: 25073444
Myostatin gene inactivation prevents skeletal muscle wasting in cancer.
Cancer research Dec, 2014 | Pubmed ID: 25336187
Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans.
PloS one , 2014 | Pubmed ID: 25337938
Effect of enforced physical inactivity induced by 60-day of bed rest on hepatic markers of NAFLD in healthy normal-weight women.
Liver international : official journal of the International Association for the Study of the Liver Jun, 2015 | Pubmed ID: 25413107
Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation.
Diabetes Jul, 2015 | Pubmed ID: 25765019
Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth.
Cancer cell Nov, 2015 | Pubmed ID: 26555173
Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion.
Molecular metabolism Nov, 2015 | Pubmed ID: 26629407
Multiple microRNA regulation of lipoprotein lipase gene abolished by 3'UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter.
Atherosclerosis Mar, 2016 | Pubmed ID: 26820803
Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research Jun, 2016 | Pubmed ID: 27281560
Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.
Cell reports Aug, 2016 | Pubmed ID: 27477273
Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance.
Physiological reports Sep, 2016 | Pubmed ID: 27597765
Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men.
European journal of applied physiology Dec, 2016 | Pubmed ID: 27632382
Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.
Cell reports Jan, 2017 | Pubmed ID: 28122233
Stephanie Chanon1,
Christine Durand1,
Aurelie Vieille-Marchiset1,
Maud Robert2,
Charna Dibner3,
Chantal Simon1,
Etienne Lefai1
1CarMeN Laboratory, INSERM U1060, INRA 1397, University of Lyon,
2Department of digestive and bariatric surgery, Obesity Integrated Center, University Hospital of Edouard Herriot, Hospices Civils de Lyon, Lyon 1 University,
3Division of Endocrinology, Diabetes, Hypertension and Nutrition, Department of Clinical Medicine, Faculty of Medicine, University of Geneva
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