Gene S. Tan

Rabies virus nucleoprotein as a carrier for foreign antigens.

Strong cellular and humoral anti-HIV Env immune responses induced by a heterologous rhabdoviral prime-boost approach.

The application of reverse genetics technology in the study of rabies virus (RV) pathogenesis and for the development of novel RV vaccines.

The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription.

PPEY motif within the rabies virus (RV) matrix protein is essential for efficient virion release and RV pathogenicity.

Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene.

Intravenous inoculation of a bat-associated rabies virus causes lethal encephalopathy in mice through invasion of the brain via neurosecretory hypothalamic fibers.

Replication-deficient rabies virus-based vaccines are safe and immunogenic in mice and nonhuman primates.

Attenuation of rabies virulence: takeover by the cytoplasmic domain of its envelope protein.

Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins.

Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes.

Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses.

Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes.

A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo.

Hemagglutinin Stalk-Reactive Antibodies Are Boosted following Sequential Infection with Seasonal and Pandemic H1N1 Influenza Virus in Mice.

A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin.

A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates.

In vivo bioluminescent imaging of influenza a virus infection and characterization of novel cross-protective monoclonal antibodies.

Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets.

Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo.

Divergent H7 immunogens offer protection from H7N9 virus challenge.

Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin.

Preexisting human antibodies neutralize recently emerged H7N9 influenza strains.

Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice.

Direct administration in the respiratory tract improves efficacy of broadly neutralizing anti-influenza virus monoclonal antibodies.

Vaccination with soluble headless hemagglutinin protects mice from challenge with divergent influenza viruses.

Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy.

Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect against Lethal H10N8 Influenza Virus Infection in Mice.

Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins.

Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate.

Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection.

Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection.

Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact.

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus.

Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner.

Synthetic TLR4 and TLR7 ligands work additively via MyD88 to induce protective antiviral immunity in mice.

Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes.

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice.

Whole-Genome Sequences of Zika Virus FLR Strains after Passage in Vero or C6/36 Cells.