Herbert Gaisano

SNAP-25, a SNARE protein, inhibits two types of K channels in esophageal smooth muscle.

The 25-kDa synaptosome-associated protein (SNAP-25) binds and inhibits delayed rectifier potassium channels in secretory cells.

Visualization of sequential exocytosis in rat pancreatic islet beta cells.

Modulation of L-type Ca(2+) channels by distinct domains within SNAP-25.

Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment.

Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.

Effects of selective endocrine or exocrine induction of AR42J on SNARE and Munc18 protein expression.

Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking.

SNAP-25 inhibits L-type Ca2+ channels in feline esophagus smooth muscle cells.

Direct interaction of target SNAREs with the Kv2.1 channel. Modal regulation of channel activation and inactivation gating.

Regulation of insulin exocytosis by Munc13-1.

Calcium source diversity in feline lower esophageal sphincter circular and sling muscle.

Syntaxin-1A binds the nucleotide-binding folds of sulphonylurea receptor 1 to regulate the KATP channel.

Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis.

Alcoholic chronic pancreatitis involves displacement of Munc18c from the pancreatic acinar basal membrane surface.

Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells.

Regional differences in L-type Ca2+ channel expression in feline lower esophageal sphincter.

Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A.

H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2.

Open form of syntaxin-1A is a more potent inhibitor than wild-type syntaxin-1A of Kv2.1 channels.

Regional differences in cholinergic regulation of potassium current in feline esophageal circular smooth muscle.

Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.

Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse.

Glucagon-like peptide 1 regulates sequential and compound exocytosis in pancreatic islet beta-cells.

Transgenic mouse overexpressing syntaxin-1A as a diabetes model.

Feline lower esophageal sphincter sling and circular muscles have different functional inhibitory neuronal responses.

Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients.

Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition.

Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25.

Involvement of VAMP-2 in exocytosis of IL-1 beta in turbot (Scophthalmus maximus) leukocytes after Vibrio anguillarum infection.

Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance.

Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells.

Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activation.

Two populations of pancreatic islet alpha-cells displaying distinct Ca2+ channel properties.

The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion.

Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels.

Recent insights into the cellular mechanisms of acute pancreatitis.

Distinct modulation of Kv1.2 channel gating by wild type, but not open form, of syntaxin-1A.

Targeting of voltage-gated K+ and Ca2+ channels and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins to cholesterol-rich lipid rafts in pancreatic alpha-cells: effects on glucagon stimulus-secretion coupling.

Characterization of VAMP-2 gene from marine teleostean, Lateolabrax japonicus.

Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C alpha phosphorylation of Munc18c.

Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis.

Effects of palmitate on insulin secretion and exocytotic proteins in islets of diabetic Goto-Kakizaki rats.

A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini.

Alcohol redirects CCK-mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis.

The actions of a novel potent islet beta-cell specific ATP-sensitive K+ channel opener can be modulated by syntaxin-1A acting on sulfonylurea receptor 1.

Modulation of the K(v)4.3 channel by syntaxin 1A.

Ca2+-dependent activator protein for secretion 1 is critical for constitutive and regulated exocytosis but not for loading of transmitters into dense core vesicles.

Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models.

Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.

Interaction of syntaxin 1A with the N-terminus of Kv4.2 modulates channel surface expression and gating.

Dynamin is functionally coupled to insulin granule exocytosis.

SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins.

Activation of exchange protein directly activated by cyclic adenosine monophosphate and protein kinase A regulate common and distinct steps in promoting plasma membrane exocytic and granule-to-granule fusions in rat islet beta cells.

Munc18-1 is critical for plasma membrane localization of syntaxin1 but not of SNAP-25 in PC12 cells.

Botulinum neurotoxin A and neurotoxin E cleavage products of synaptosome-associated protein of 25 kd exhibit distinct actions on pancreatic islet beta-cell Kv2.1 channel gating.

Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels.

Munc18/SNARE proteins' regulation of exocytosis in guinea pig duodenal Brunner's gland acini.

The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells.

Pancreatic islet alpha cell commands itself: secrete more glucagon!

VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis.

Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice.

Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.

Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel.

Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines.

Rescuing the subprime meltdown in insulin exocytosis in diabetes.

High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.

New insights into the mechanisms of pancreatitis.

Cab45b, a Munc18b-interacting partner, regulates exocytosis in pancreatic beta-cells.

Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells.

POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP.

Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets.

Deletion of Fas in the pancreatic beta-cells leads to enhanced insulin secretion.

Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells.

Hypoxia-reoxygenation increase invasiveness of PANC-1 cells through Rac1/MMP-2.

Insulin treatment and high-fat diet feeding reduces the expression of three Tcf genes in rodent pancreas.

Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes.

Unperturbed islet α-cell function examined in mouse pancreas tissue slices.

SNARE protein regulation of cardiac potassium channels and atrial natriuretic factor secretion.

Erythropoietin protects against diabetes through direct effects on pancreatic beta cells.

Nitric oxide activation of a potassium channel (BK(Ca)) in feline lower esophageal sphincter.

ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic beta-cell KATP channels.

Syntaxin 1A regulates surface expression of beta-cell ATP-sensitive potassium channels.

TGF-β1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-κB/IL-6/MMP-2.

SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans.

Live pancreatic acinar imaging of exocytosis using syncollin-pHluorin.

Syntaxin-1A interacts with distinct domains within nucleotide-binding folds of sulfonylurea receptor 1 to inhibit beta-cell ATP-sensitive potassium channels.

Electrophysiological identification of mouse islet α-cells: from isolated single α-cells to in situ assessment within pancreas slices.

Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion.

Syntaxin-1A inhibits KATP channels by interacting with specific conserved motifs within sulfonylurea receptor 2A.

Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice.

Molecular control of compound Exocytosis: A key role for VAMP8.

In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking.

Effects of ethanol metabolites on exocytosis of pancreatic acinar cells in rats.

Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth.

Glucagon secretion and signaling in the development of diabetes.

In situ electrophysiological examination of pancreatic α cells in the streptozotocin-induced diabetes model, revealing the cellular basis of glucagon hypersecretion.

Role of the SNARE protein SNAP23 on cAMP-stimulated renin release in mouse juxtaglomerular cells.

RalA GTPase tethers insulin granules to L- and R-type calcium channels through binding α2 δ-1 subunit.

Munc18b is a major mediator of insulin exocytosis in rat pancreatic β-cells.

An exploratory study of the association between KCNB1 rs1051295 and type 2 diabetes and its related traits in Chinese Han population.

UCP2 regulates the glucagon response to fasting and starvation.

Somatostatin receptor type 2 antagonism improves glucagon counterregulation in biobreeding diabetic rats.

Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.

Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell.

Role of vesicle-associated membrane protein 2 in exocytosis of glucagon-like peptide-1 from the murine intestinal L cell.

Phosphatidylinositol 4,5-biphosphate (PIP2) modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic β-cell ATP-sensitive potassium channels.

Biliopancreatic route for effective viral transduction of pancreatic islets.

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells.

Here come the newcomer granules, better late than never.

Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature.

α/β-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion.

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.

Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.

Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.

PTEN deletion in pancreatic α-cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance.

Vesicle associated membrane protein 8 (VAMP8)-mediated zymogen granule exocytosis is dependent on endosomal trafficking via the constitutive-like secretory pathway.

Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells.

Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.

The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis.

Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION.

Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells.

ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation.

A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells.

Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets.

Association of KCNB1 polymorphisms with lipid metabolisms and insulin resistance: a case-control design of population-based cross-sectional study in Chinese Han population.

Cell-to-Cell Communication and the Regulation of Pancreatic Function.

Erratum to: Association of KCNB1 polymorphisms with lipid metabolisms and insulin resistance: a case-control design of population-based cross-sectional study in Chinese Han population.

Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells.

Cell polarity defines three distinct domains in pancreatic β-cells.

Changes in beta cell function occur in prediabetes and early disease in the Lepr (db) mouse model of diabetes.

Association of Diabetes and Prognosis of Minor Stroke and Its Subtypes: A Prospective Observational Study.

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells.

New Roles of Syntaxin-1A in Insulin Granule Exocytosis and Replenishment.

Palmitic acid increases invasiveness of pancreatic cancer cells AsPC-1 through TLR4/ROS/NF-κB/MMP-9 signaling pathway.

Post-Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke.

Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis.

Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis.

Ex vivo human pancreatic slice preparations offer a valuable model for studying pancreatic exocrine biology.

Association between Indices of Body Composition and Abnormal Metabolic Phenotype in Normal-Weight Chinese Adults.

The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1.

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.