Kelvin Yen

Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression.

Lifespan is not determined by metabolic rate: evidence from fishes and C. elegans.

Impaired glucose signaling as a cause of obesity and the metabolic syndrome: the glucoadipostatic hypothesis.

Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease.

Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: a metabolic mechanism resolving the paradox.

Chemosensory and caloric mechanisms influence distinct components of mortality rate.

Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan.

SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold.

Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans.

Converging pathways in lifespan regulation.

Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling.

A new DAF-16 isoform regulates longevity.

DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road.

A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods.

PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.

FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity.

Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes.

The emerging role of the mitochondrial-derived peptide humanin in stress resistance.

Humanin: a harbinger of mitochondrial-derived peptides?

IGF-I regulates the age-dependent signaling peptide humanin.

Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants.

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers.

The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus.

Mitochondrially derived peptides as novel regulators of metabolism.

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity.