Stephen A. Duncan
Department of Regenerative Medicine and Cell Biology
Medical University of South Carolina
Stephen Duncan received his PhD for working on vaccinia virus from Oxford University in 1992. He then moved to Rockefeller University in New York City to undertake a postdoctoral fellowship in the laboratory of Dr. James Darnell. He relocated to the Medical College of Wisconsin, Milwaukee in 1997 to establish an independent laboratory as an Assistant Professor and moved through the ranks to become the Marcus Professor of Cell Biology, Neurobiology and Anatomy. In 2007, he accepted a position as the founding Director of MCW’s Program in Regenerative Medicine. In 2015, Dr. Duncan relocated to the Medical University of South Carolina in Charleston, where he is currently the Chair of the Department of Regenerative Medicine and Cell Biology.
Research in the Duncan Lab focuses on the use of mice and stem cells to understand the contribution of transcription factors to embryonic development and function of the liver. His group has developed technologies to control the differentiation of pluripotent stem cells into cells with hepatocyte characteristics. In addition to using such cells to understand cell differentiation, his group has exploited them to model inborn errors in hepatic metabolism and as a platform for drug discovery.
FGF2 mediates hepatic progenitor cell formation during human pluripotent stem cell differentiation by inducing the WNT antagonist NKD1.
Genes & development Dec, 2015 | Pubmed ID: 26637527
Liver Capsule: Multipotent stem cells and their lineage restriction to hepatocytes.
Hepatology (Baltimore, Md.) 10, 2016 | Pubmed ID: 27405444
Mapping the Cell-Surface N-Glycoproteome of Human Hepatocytes Reveals Markers for Selecting a Homogeneous Population of iPSC-Derived Hepatocytes.
Stem cell reports 09, 2016 | Pubmed ID: 27569060
N-glycoprotein surfaceome of human induced pluripotent stem cell derived hepatic endoderm.
Proteomics Mar, 2017 | Pubmed ID: 27966262
ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion.
EBioMedicine Apr, 2017 | Pubmed ID: 28330813
A small-molecule screen reveals that HSP90β promotes the conversion of induced pluripotent stem cell-derived endoderm to a hepatic fate and regulates HNF4A turnover.
Development (Cambridge, England) 05, 2017 | Pubmed ID: 28360131
A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia.
Cell stem cell 04, 2017 | Pubmed ID: 28388428
Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.
Cell stem cell 04, 2017 | Pubmed ID: 28388432
Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress.
Cell reports 05, 2017 | Pubmed ID: 28514664
GATA6 is essential for endoderm formation from human pluripotent stem cells.
Biology open Jul, 2017 | Pubmed ID: 28606935
Modeling Inborn Errors of Hepatic Metabolism Using Induced Pluripotent Stem Cells.
Arteriosclerosis, thrombosis, and vascular biology Nov, 2017 | Pubmed ID: 28818857
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