James K. Chen

Medulloblastoma growth inhibition by hedgehog pathway blockade.

Small molecule modulation of Smoothened activity.

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.

Small-molecule regulation of zebrafish gene expression.

Light-controlled gene silencing in zebrafish embryos.

Gene regulation technologies in zebrafish.

Fish 'n clicks.

Chemical technologies for probing embryonic development.

The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning.

A small molecule that binds Hedgehog and blocks its signaling in human cells.

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.

Converse conformational control of smoothened activity by structurally related small molecules.

Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent.

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.

Versatile synthesis and rational design of caged morpholinos.

Controlling destiny through chemistry: small-molecule regulators of cell fate.

Oligonucleotide-based tools for studying zebrafish development.

Synthetic strategies for studying embryonic development.

Targeted and Conditional Gene Expression Workshop, 8th International Conference on Zebrafish Development and Genetics.

Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways.

Spatiotemporal control of embryonic gene expression using caged morpholinos.

A crucial requirement for Hedgehog signaling in small cell lung cancer.

A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury.

Neuropilins are positive regulators of Hedgehog signal transduction.

Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish.

Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons.

Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development.