Department of Microbiology and Immunology,
Yong Loo Lin School of Medicine,
Immunology Programme,
Life Sciences Institute,
Department of Microbiology and Immunology, Yong Loo Lin School of Medicine,
Immunology Programme, Life Sciences Institute
I got the Ph. D degree in China Agricultural University on 2010. From then on, I continued performing research in China Agricultural University, and worked as an assistant professor, associate professor and Professor up to now. During this period, I had gone to UC Berkeley and UC Davis to work as a visiting scholar. Currently, I mainly focus on the study of virus-host interactions, R gene-mediated resistance against virus and plant virus-based vector development.
Production of transgenic pigs mediated by pseudotyped lentivirus and sperm.
PloS one , 2012 | Pubmed ID: 22536374
Molecular cloning and ontogenesis expression of fatty acid transport protein-1 in yellow-feathered broilers.
Journal of genetics and genomics = Yi chuan xue bao Jun, 2008 | Pubmed ID: 18571120
Development of Tobacco necrosis virus A as a vector for efficient and stable expression of FMDV VP1 peptides.
Plant biotechnology journal May, 2010 | Pubmed ID: 20331532
Global comparison of gene expression profiles between intramuscular and subcutaneous adipocytes of neonatal landrace pig using microarray.
Meat science Oct, 2010 | Pubmed ID: 20573458
Oral administration of plant-based rotavirus VP6 induces antigen-specific IgAs, IgGs and passive protection in mice.
Vaccine Aug, 2010 | Pubmed ID: 20637305
A comprehensive expression profile of microRNAs in porcine pituitary.
PloS one , 2011 | Pubmed ID: 21969866
Regulation of leucine catabolism by metabolic fuels in mammary epithelial cells.
Amino acids Nov, 2012 | Pubmed ID: 22543725
Nutritional and regulatory role of branched-chain amino acids in lactation.
Frontiers in bioscience (Landmark edition) Jun, 2012 | Pubmed ID: 22652809
Hormonal regulation of leucine catabolism in mammary epithelial cells.
Amino acids Sep, 2013 | Pubmed ID: 22707151
Effects of "Bioactive" amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks.
Journal of animal science and biotechnology Aug, 2012 | Pubmed ID: 22958345
Validation of reference genes for gene expression studies in virus-infected Nicotiana benthamiana using quantitative real-time PCR.
PloS one , 2012 | Pubmed ID: 23029521
Fatty Acid and Transcriptome Profiling of Longissimus Dorsi Muscles between Pig Breeds Differing in Meat Quality.
International journal of biological sciences , 2013 | Pubmed ID: 23355796
N-terminal basic amino acid residues of Beet black scorch virus capsid protein play a critical role in virion assembly and systemic movement.
Virology journal Jun, 2013 | Pubmed ID: 23786675
Glucose utilization, lipid metabolism and BMP-Smad signaling pathway of porcine intramuscular preadipocytes compared with subcutaneous preadipocytes.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2013 | Pubmed ID: 23860035
Tolerogenic vaccination reduced effector memory CD4 T cells and induced effector memory Treg cells for type I diabetes treatment.
PloS one , 2013 | Pubmed ID: 23894591
Selection of reference genes for gene expression studies in virus-infected monocots using quantitative real-time PCR.
Journal of biotechnology Oct, 2013 | Pubmed ID: 23954326
MiRNA-181a regulates adipogenesis by targeting tumor necrosis factor-α (TNF-α) in the porcine model.
PloS one , 2013 | Pubmed ID: 24098322
Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2013 | Pubmed ID: 24248350
Deep sequencing-based transcriptome profiling reveals comprehensive insights into the responses of Nicotiana benthamiana to beet necrotic yellow vein virus infections containing or lacking RNA4.
PloS one , 2014 | Pubmed ID: 24416380
Effect of diacylglycerol acyltransferase 2 overexpression in 3T3-L1 is associated to an increase in mono-unsaturated fatty acid accumulation.
Journal of animal science and biotechnology , 2014 | Pubmed ID: 24982757
Differential regulation of proinflammatory cytokine expression by mitogen-activated protein kinases in macrophages in response to intestinal parasite infection.
Infection and immunity Nov, 2014 | Pubmed ID: 25156742
STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation.
Cell research Dec, 2014 | Pubmed ID: 25412660
Characterization of the complete genome of Barley yellow striate mosaic virus reveals a nested gene encoding a small hydrophobic protein.
Virology Apr, 2015 | Pubmed ID: 25666524
MAPK Phosphatase 7 Regulates T Cell Differentiation via Inhibiting ERK-Mediated IL-2 Expression.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2015 | Pubmed ID: 25716993
MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response.
Cell reports Mar, 2015 | Pubmed ID: 25772359
Casein kinase II controls TBK1/IRF3 activation in IFN response against viral infection.
Journal of immunology (Baltimore, Md. : 1950) May, 2015 | Pubmed ID: 25810395
MAP kinase phosphatase 2 regulates macrophage-adipocyte interaction.
PloS one , 2015 | Pubmed ID: 25816341
Morphogenesis of Endoplasmic Reticulum Membrane-Invaginated Vesicles during Beet Black Scorch Virus Infection: Role of Auxiliary Replication Protein and New Implications of Three-Dimensional Architecture.
Journal of virology Jun, 2015 | Pubmed ID: 25833056
Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5.
The Journal of biological chemistry Jun, 2015 | Pubmed ID: 25922079
Phosphorylation of TGB1 by protein kinase CK2 promotes barley stripe mosaic virus movement in monocots and dicots.
Journal of experimental botany Aug, 2015 | Pubmed ID: 25998907
Phosphorylation of Beet black scorch virus coat protein by PKA is required for assembly and stability of virus particles.
Scientific reports Jun, 2015 | Pubmed ID: 26108567
Transcriptome Analysis of Beta macrocarpa and Identification of Differentially Expressed Transcripts in Response to Beet Necrotic Yellow Vein Virus Infection.
PloS one , 2015 | Pubmed ID: 26196682
MAPK phosphatase 5 inhibits IRF3.
Oncotarget Aug, 2015 | Pubmed ID: 26305722
N-Oleoyl glycine, a lipoamino acid, stimulates adipogenesis associated with activation of CB1 receptor and Akt signaling pathway in 3T3-L1 adipocyte.
Biochemical and biophysical research communications Oct, 2015 | Pubmed ID: 26365347
Architecture of viral replication factories.
Oncotarget Oct, 2015 | Pubmed ID: 26429866
α-Lipoic Acids Promote the Protein Synthesis of C2C12 Myotubes by the TLR2/PI3K Signaling Pathway.
Journal of agricultural and food chemistry Mar, 2016 | Pubmed ID: 26855124
Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells.
Biochemical and biophysical research communications Mar, 2016 | Pubmed ID: 26879142
Capsules of virulent pneumococcal serotypes enhance formation of neutrophil extracellular traps during in vivo pathogenesis of pneumonia.
Oncotarget Apr, 2016 | Pubmed ID: 27034012
Enhanced Proliferation of Porcine Bone Marrow Mesenchymal Stem Cells Induced by Extracellular Calcium is Associated with the Activation of the Calcium-Sensing Receptor and ERK Signaling Pathway.
Stem cells international , 2016 | Pubmed ID: 27123007
Regulatory Roles of MAPK Phosphatases in Cancer.
Immune network Apr, 2016 | Pubmed ID: 27162525
Alpha-ketoglutarate promotes skeletal muscle hypertrophy and protein synthesis through Akt/mTOR signaling pathways.
Scientific reports 05, 2016 | Pubmed ID: 27225984
Epigallocatechin Gallate Reduces Slow-Twitch Muscle Fiber Formation and Mitochondrial Biosynthesis in C2C12 Cells by Repressing AMPK Activity and PGC-1α Expression.
Journal of agricultural and food chemistry Aug, 2016 | Pubmed ID: 27420899
The dipeptide Pro-Asp promotes IGF-1 secretion and expression in hepatocytes by enhancing JAK2/STAT5 signaling pathway.
Molecular and cellular endocrinology 11, 2016 | Pubmed ID: 27473671
Monocyte-derived factors including PLA2G7 induced by macrophage-nasopharyngeal carcinoma cell interaction promote tumor cell invasiveness.
Oncotarget 08, 2016 | Pubmed ID: 27487154
Ex Vivo and In Vivo Mice Models to Study Blastocystis spp. Adhesion, Colonization and Pathology: Closer to Proving Koch's Postulates.
PloS one , 2016 | Pubmed ID: 27508942
Cd47-Sirpα interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells.
Proceedings of the National Academy of Sciences of the United States of America 09, 2016 | Pubmed ID: 27578867
Vaccination with Astragalus and Ginseng Polysaccharides Improves Immune Response of Chickens against H5N1 Avian Influenza Virus.
BioMed research international , 2016 | Pubmed ID: 27597953
Blomia tropicalis-Specific TCR Transgenic Th2 Cells Induce Inducible BALT and Severe Asthma in Mice by an IL-4/IL-13-Dependent Mechanism.
Journal of immunology (Baltimore, Md. : 1950) 11, 2016 | Pubmed ID: 27733553
Improved Pathogenicity of a Beet Black Scorch Virus Variant by Low Temperature and Co-infection with Its Satellite RNA.
Frontiers in microbiology , 2016 | Pubmed ID: 27867378
Lauric Acid Stimulates Mammary Gland Development of Pubertal Mice through Activation of GPR84 and PI3K/Akt Signaling Pathway.
Journal of agricultural and food chemistry Jan, 2017 | Pubmed ID: 27978622
N-Oleoylglycine-Induced Hyperphagia Is Associated with the Activation of Agouti-Related Protein (AgRP) Neuron by Cannabinoid Receptor Type 1 (CB1R).
Journal of agricultural and food chemistry Feb, 2017 | Pubmed ID: 28102080
Characterization of faecal microbial communities of dairy cows fed diets containing ensiled Moringa oleifera fodder.
Scientific reports 01, 2017 | Pubmed ID: 28134261
Dietary protein-induced hepatic IGF-1 secretion mediated by PPARγ activation.
PloS one , 2017 | Pubmed ID: 28257428
The Barley stripe mosaic virus γb protein promotes chloroplast-targeted replication by enhancing unwinding of RNA duplexes.
PLoS pathogens Apr, 2017 | Pubmed ID: 28388677
Phytol Promotes the Formation of Slow-Twitch Muscle Fibers through PGC-1α/miRNA but Not Mitochondria Oxidation.
Journal of agricultural and food chemistry Jul, 2017 | Pubmed ID: 28654264
Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice.
Biochemical and biophysical research communications 09, 2017 | Pubmed ID: 28712865
Three-Dimensional Analysis of Chloroplast Structures Associated with Virus Infection.
Plant physiology 01, 2018 | Pubmed ID: 28821590
Hijacking of the nucleolar protein fibrillarin by TGB1 is required for cell-to-cell movement of Barley stripe mosaic virus.
Molecular plant pathology 05, 2018 | Pubmed ID: 28872759
Heparin Increases Food Intake through AgRP Neurons.
Cell reports Sep, 2017 | Pubmed ID: 28877477
α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 01, 2018 | Pubmed ID: 28939592
Succinate promotes skeletal muscle protein synthesis via Erk1/2 signaling pathway.
Molecular medicine reports Nov, 2017 | Pubmed ID: 28944867
Construction of infectious clones of lychnis ringspot virus and evaluation of its relationship with barley stripe mosaic virus by reassortment of genomic RNA segments.
Virus research 01, 2018 | Pubmed ID: 29054449
Dual-Specificity Phosphatase 12 Targets p38 MAP Kinase to Regulate Macrophage Response to Intracellular Bacterial Infection.
Frontiers in immunology , 2017 | Pubmed ID: 29062315
Barley Stripe Mosaic Virus γb Interacts with Glycolate Oxidase and Inhibits Peroxisomal ROS Production to Facilitate Virus Infection.
Molecular plant 02, 2018 | Pubmed ID: 29066357
Diversity effect of capsaicin on different types of skeletal muscle.
Molecular and cellular biochemistry Jun, 2018 | Pubmed ID: 29159769
Laminarin counteracts diet-induced obesity associated with glucagon-like peptide-1 secretion.
Oncotarget Nov, 2017 | Pubmed ID: 29245916
A novel two-component system modulates quorum sensing and pathogenicity in Burkholderia cenocepacia.
Molecular microbiology Apr, 2018 | Pubmed ID: 29363827
Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Plant Virus Replication.
Frontiers in plant science , 2018 | Pubmed ID: 29441085
Barley stripe mosaic virus infection requires PKA-mediated phosphorylation of γb for suppression of both RNA silencing and the host cell death response.
The New phytologist 06, 2018 | Pubmed ID: 29453938
Hsc70-2 is required for Beet black scorch virus infection through interaction with replication and capsid proteins.
Scientific reports 03, 2018 | Pubmed ID: 29540800
γb Protein Subverts Autophagy to Promote Viral Infection by Disrupting the ATG7-ATG8 Interaction.
The Plant cell 07, 2018 | Pubmed ID: 29848767
Age-Related Changes in MicroRNA in the Rat Pituitary and Potential Role in GH Regulation.
International journal of molecular sciences Jul, 2018 | Pubmed ID: 30011963
The effect of dietary ginseng polysaccharide supplementation on porcine milk-derived esRNAs involved in the host immune responses.
Journal of animal physiology and animal nutrition Jan, 2019 | Pubmed ID: 30407669
MiR-125b-2 Knockout in Testis Is Associated with Targeting to the PAP Gene, Mitochondrial Copy Number, and Impaired Sperm Quality.
International journal of molecular sciences Jan, 2019 | Pubmed ID: 30609807
Interaction between Brassica yellows virus silencing suppressor P0 and plant SKP1 facilitates stability of P0 in vivo against degradation by proteasome and autophagy pathways.
The New phytologist 05, 2019 | Pubmed ID: 30664234
Disruption of Quorum Sensing and Virulence in by a Structural Analogue of the -2-Dodecenoic Acid Signal.
Applied and environmental microbiology 04, 2019 | Pubmed ID: 30770405
The beneficial effects of leaf on reproductive performance in mice.
Food science & nutrition Feb, 2019 | Pubmed ID: 30847152
A barley stripe mosaic virus-based guide RNA delivery system for targeted mutagenesis in wheat and maize.
Molecular plant pathology 10, 2019 | Pubmed ID: 31273916
TurboID-based proximity labeling reveals that UBR7 is a regulator of N NLR immune receptor-mediated immunity.
Nature communications 07, 2019 | Pubmed ID: 31324801
Oral supplementation with ginseng polysaccharide promotes food intake in mice.
Brain and behavior 09, 2019 | Pubmed ID: 31392839
Construction of an Infectious cDNA Clone and Comparisons of Hordeivirus Cytopathology and Pathogenicity.
Phytopathology Jan, 2020 | Pubmed ID: 31483225
Lower methionine/cystine ratio in low-protein diet improves animal reproductive performance by modulating methionine cycle.
Food science & nutrition Sep, 2019 | Pubmed ID: 31572580
Hepatic exosome-derived miR-130a-3p attenuates glucose intolerance via suppressing PHLPP2 gene in adipocyte.
Metabolism: clinical and experimental 02, 2020 | Pubmed ID: 31715176
Genomewide analysis of circular RNA in pituitaries of normal and heat-stressed sows.
BMC genomics Dec, 2019 | Pubmed ID: 31870281
Exploration of targets regulated by miR-125b in porcine adipocytes.
In vitro cellular & developmental biology. Animal Feb, 2020 | Pubmed ID: 31912457
Dietary thymol supplementation promotes skeletal muscle fibre type switch in longissimus dorsi of finishing pigs.
Journal of animal physiology and animal nutrition Mar, 2020 | Pubmed ID: 31975464
miR-709 inhibits GHRP6 induced GH synthesis by targeting PRKCA in pituitary.
Molecular and cellular endocrinology Apr, 2020 | Pubmed ID: 32084499
Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation.
The EMBO journal Apr, 2020 | Pubmed ID: 32104923
Emerging Roles of Heat-Induced circRNAs Related to Lactogenesis in Lactating Sows.
Frontiers in genetics , 2019 | Pubmed ID: 32117411
Genome-Wide microRNA Profiling Using Oligonucleotide Microarray Reveals Regulatory Networks of microRNAs in During Beet Necrotic Yellow Vein Virus Infection.
Viruses Mar, 2020 | Pubmed ID: 32178444
MiR-130a-3p Inhibits PRL Expression and Is Associated With Heat Stress-Induced PRL Reduction.
Frontiers in endocrinology , 2020 | Pubmed ID: 32194503
Oral Administration of Bovine and Porcine Milk Exosome Alter miRNAs Profiles in Piglet Serum.
Scientific reports Apr, 2020 | Pubmed ID: 32332796
Milk exosome-derived miRNAs from water buffalo are implicated in immune response and metabolism process.
BMC veterinary research Apr, 2020 | Pubmed ID: 32349776
Yongliang Zhang*,1,
Yuanyuan Li*,2,3,
Xinxin Yang1,
Zhiyan Wen1,
Ugrappa Nagalakshmi2,
Savithramma P. Dinesh-Kumar2,3
1State Key Laboratory of Agro-Biotechnology and Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University,
2Department of Plant Biology, College of Biological Sciences, University of California, Davis,
3Genome Center, College of Biological Sciences, University of California, Davis
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