Nathan Basisty
Buck Institute for Research on Aging
Dr. Nathan Basisty is currently an Investigator at the NIA and head of the Translational Geroproteomics Unit (TGU). He received his Ph.D. in Pathology and B.S. in Biochemistry from the University of Washington, where he investigated the role of protein turnover in mammalian aging and longevity using novel combinations of metabolic labeling, LC-MS/MS, and software tools. In 2015, he joined The Buck Institute for Research on Aging, where he did his postdoctoral fellowship in the labs of Dr. Birgit Schilling and Dr. Judith Campisi. There he developed novel and specialized proteomic approaches to understand aging processes and age-related diseases, including the application of data-independent acquisition (DIA) or SWATH workflows to identify and quantify PTMs and secretomes. Dr. Basisty’s awards include two “Aging Cell Best Paper Prizes”, in 2014 and 2017 and the Joseph A. Pignolo, Sr. Award in Aging Research 2016, and the prestigious K99/R00 Pathway to Independence Award in 2020.
Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant.
Nucleic acids research Nov, 2016 | Pubmed ID: 27596602
Stable Isotope Labeling Reveals Novel Insights Into Ubiquitin-Mediated Protein Aggregation With Age, Calorie Restriction, and Rapamycin Treatment.
The journals of gerontology. Series A, Biological sciences and medical sciences 04, 2018 | Pubmed ID: 28958078
Protein Turnover in Aging and Longevity.
Proteomics Mar, 2018 | Pubmed ID: 29453826
Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity.
Cell reports 04, 2018 | Pubmed ID: 29617653
Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity Enrichment.
Proteomics 09, 2018 | Pubmed ID: 30035354
Identifying ubiquitinated proteins and aggregates.
Aging 10, 2018 | Pubmed ID: 30335616
Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.
PloS one , 2018 | Pubmed ID: 30586434
Global Lysine Acetylation in Results from Growth Conditions That Favor Acetate Fermentation.
Journal of bacteriology 05, 2019 | Pubmed ID: 30782634
Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions.
Frontiers in microbiology , 2019 | Pubmed ID: 31354686
Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity.
Proteomics Aug, 2019 | Pubmed ID: 31408259
Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI.
Journal of the American Society of Nephrology : JASN Dec, 2019 | Pubmed ID: 31575700
A proteomic atlas of senescence-associated secretomes for aging biomarker development.
PLoS biology Jan, 2020 | Pubmed ID: 31945054
Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ.
The Journal of biological chemistry Feb, 2020 | Pubmed ID: 31953319
The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications.
Expert review of proteomics Apr, 2020 | Pubmed ID: 32425074
Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice.
eLife , | Pubmed ID: 32648542
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