Richard I. Christopherson

Inhibitors of de novo nucleotide biosynthesis as drugs.

Antibody arrays: an embryonic but rapidly growing technology.

Crystallization of hamster dihydroorotase: involvement of a disulfide-linked tetrameric form.

Identification of repertoires of surface antigens on leukemias using an antibody microarray.

Metabolic response patterns of nucleotides in B-cell chronic lymphocytic leukaemias to cladribine, fludarabine and deoxycoformycin.

Dihydroorotase from Escherichia coli: loop movement and cooperativity between subunits.

Conservation of unique cell-surface CD antigen mosaics in HIV-1-infected individuals.

Immunophenotypic changes induced on human HL60 leukaemia cells by 1alpha,25-dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol-13-acetate.

Human epidermal and monocyte-derived langerhans cells express functional P2X receptors.

Screening microarrays of novel monoclonal antibodies for binding to T-, B- and myeloid leukaemia cells.

Multiplex detection of surface molecules on colorectal cancers.

Classification of AML using a monoclonal antibody microarray.

13C and 15N isotope effects for conversion of L-dihydroorotate to N-carbamyl-L-aspartate using dihydroorotase from hamster and Bacillus caldolyticus.

Thermodynamic analysis of catalysis by the dihydroorotases from hamster and Bacillus caldolyticus, as compared with the uncatalyzed reaction.

The application of CD antigen proteomics to pharmacogenomics.

Analysis of human leukaemias and lymphomas using extensive immunophenotypes from an antibody microarray.

The nuclear proteome and DNA-binding fraction of human Raji lymphoma cells.

Structures of ligand-free and inhibitor complexes of dihydroorotase from Escherichia coli: implications for loop movement in inhibitor design.

All-trans retinoic acid induces different immunophenotypic changes on human HL60 and NB4 myeloid leukaemias.

Differentially expressed cytosolic proteins in human leukemia and lymphoma cell lines correlate with lineages and functions.

Kinetic and structural analysis of mutant Escherichia coli dihydroorotases: a flexible loop stabilizes the transition state.

Profiling of apoptotic changes in human breast cancer cells using SELDI-TOF mass spectrometry.

Structure and inhibition of orotidine 5'-monophosphate decarboxylase from Plasmodium falciparum.

The applicability of a cluster of differentiation monoclonal antibody microarray to the diagnosis of human disease.

Profiling CD antigens on leukaemias with an antibody microarray.

Membrane proteomics for leukemia classification and drug target identification.

Surface antigen profiling of colorectal cancer using antibody microarrays with fluorescence multiplexing.

An extended antibody microarray for surface profiling metastatic melanoma.

Differentially expressed nuclear proteins in human CCRF-CEM, HL-60, MEC-1 and Raji cells correlate with cellular properties.

Comprehensive proteomic analysis of the effects of purine analogs on human Raji B-cell lymphoma.

Cell surface markers in colorectal cancer prognosis.

Surface profiles for sub-classification of chronic lymphocytic leukemia.

Cladribine and Fludarabine Nucleoside Change the Levels of CD Antigens on B-Lymphoproliferative Disorders.

Biomarkers of Breast Cancer Apoptosis Induced by Chemotherapy and TRAIL.

The Hsp90 inhibitor SNX-7081 synergizes with and restores sensitivity to fludarabine in chronic lymphocytic leukemia cells with lesions in the TP53 pathway: a potential treatment strategy for fludarabine refractory disease.

The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells.