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Department of Neuroscience
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The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.
Human molecular genetics Jul, 2014 | Pubmed ID: 24594842
Decreased expression of glutamate transporter GLAST in Bergmann glia is associated with the loss of Purkinje neurons in the spinocerebellar ataxia type 1.
Cerebellum (London, England) Feb, 2015 | Pubmed ID: 25255716
Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.
Neuroscience Mar, 2015 | Pubmed ID: 25595967
Ataxin-1 regulates proliferation of hippocampal neural precursors.
Neuroscience May, 2016 | Pubmed ID: 26876606
Mutant Ataxin-1 Inhibits Neural Progenitor Cell Proliferation in SCA1.
Cerebellum (London, England) 04, 2017 | Pubmed ID: 27306906
Inhibition of Vascular Endothelial Growth Factor Receptor 2 Exacerbates Loss of Lower Motor Neurons and Axons during Experimental Autoimmune Encephalomyelitis.
PloS one , 2016 | Pubmed ID: 27466819
Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice.
Journal of neuroinflammation 05, 2017 | Pubmed ID: 28545543
Inhibition of NF-κB signaling in IKKβF/F;LysM Cre mice causes motor deficits but does not alter pathogenesis of Spinocerebellar ataxia type 1.
PloS one , 2018 | Pubmed ID: 29975753
Astroglia contribute to the pathogenesis of spinocerebellar ataxia Type 1 (SCA1) in a biphasic, stage-of-disease specific manner.
Glia 09, 2018 | Pubmed ID: 30043530
Role of Microglia in Ataxias.
Journal of molecular biology 04, 2019 | Pubmed ID: 30660620
Brain Derived Neurotrophic Factor (BDNF) Delays Onset of Pathogenesis in Transgenic Mouse Model of Spinocerebellar Ataxia Type 1 (SCA1).
Frontiers in cellular neuroscience , 2018 | Pubmed ID: 30718999
Microglial Self-Recognition STINGs in A-T Neurodegeneration.
Trends in neurosciences 11, 2019 | Pubmed ID: 31623867
Cerebellar contribution to the cognitive alterations in SCA1: evidence from mouse models.
Human molecular genetics 01, 2020 | Pubmed ID: 31696233
University of Minnesota
Katherine A. Hamel1,
Marija Cvetanovic1
1Department of Neuroscience, University of Minnesota
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