Charles A. Parkos

Department of Pathology, University of Michigan, Ann Arbor

Affiliated withUniversity of Michigan, Ann Arbor University of Michigan

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

Article Total : 2	Year
Publication title	2021
Publication title	2021

Other Publications

Article	Year
Challenges in IBD Research: Update on Progress and Prioritization of the CCFA's Research Agenda. Inflammatory bowel diseases\| PubMed ID: 23448796	2013
Junctional adhesion molecule A promotes epithelial tight junction assembly to augment lung barrier function. The American journal of pathology\| PubMed ID: 25438062	2015
Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. The Journal of clinical investigation\| PubMed ID: 25664854	2015
HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation. The American journal of pathology\| PubMed ID: 26216285	2015
Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier. Molecular biology of the cell\| PubMed ID: 26224314	2015
Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26590314	2016
Targeting of Neutrophil Lewis X Blocks Transepithelial Migration and Increases Phagocytosis and Degranulation. The American journal of pathology\| PubMed ID: 26687991	2016
Neutrophil-Epithelial Interactions: A Double-Edged Sword. The American journal of pathology\| PubMed ID: 27083514	2016
Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol. Gastroenterology\| PubMed ID: 27342212	2016
Redox control of Cas phosphorylation requires Abl kinase in regulation of intestinal epithelial cell spreading and migration. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 27418680	2016
Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair. Gastroenterology\| PubMed ID: 27436072	2016
Deposition of microparticles by neutrophils onto inflamed epithelium: a new mechanism to disrupt epithelial intercellular adhesions and promote transepithelial migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 27553226	2016
Pathobiology of neutrophil-epithelial interactions. Immunological reviews\| PubMed ID: 27558330	2016
Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascades. Tissue barriers\| PubMed ID: 27583195	2016
IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria. Mucosal immunology\| PubMed ID: 27624780	2017
Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE. Journal of leukocyte biology\| PubMed ID: 27965383	2017
Expression of Lewis-a glycans on polymorphonuclear leukocytes augments function by increasing transmigration. Journal of leukocyte biology\| PubMed ID: 28600306	2017
Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling. The Journal of clinical investigation\| PubMed ID: 28783045
Role of negative regulation of immune signaling pathways in neutrophil function. Journal of leukocyte biology\| PubMed ID: 29345376	2017
Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines. Cell death & disease\| PubMed ID: 29523777
Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to . Frontiers in immunology\| PubMed ID: 29881378	2018
Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model. JCI insight\| PubMed ID: 30333307	2018
Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation. Molecular biology of the cell\| PubMed ID: 30625033	2019
Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice. Mucosal immunology\| PubMed ID: 30745566	2019
Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8 T-Cell Activation. Frontiers in immunology\| PubMed ID: 30936879	2019
TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium. Mucosal immunology\| PubMed ID: 30971752
Innate immune cell-epithelial crosstalk during wound repair. The Journal of clinical investigation\| PubMed ID: 31329162	2019
Formyl peptide receptor 2 regulates monocyte recruitment to promote intestinal mucosal wound repair. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31585047
Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo. Nature communications\| PubMed ID: 31676794
Regulation of neutrophil function by selective targeting of glycan epitopes expressed on the integrin CD11b/CD18. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31907993	2020
Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration. Molecular biology of the cell\| PubMed ID: 31967937	2020
Western diet-induced increase in colonic bile acids compromises epithelial barrier in nonalcoholic steatohepatitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32275114	2020
Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32300016
Targeting epithelial expressed Sialyl Lewis glycans improves colonic mucosal wound healing and protects against colitis. JCI insight\| PubMed ID: 32427587
Blocking integrin αβ-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis. Journal of hepatology\| PubMed ID: 32540177	2020
Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo. Mucosal immunology\| PubMed ID: 32561828	2020
Dysregulation of intestinal epithelial CFTR-dependent Cl ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice. Mucosal immunology\| PubMed ID: 32576925	2021
WD40 Repeat Protein 26 Negatively Regulates Formyl Peptide Receptor-1 Mediated Wound Healing in Intestinal Epithelial Cells. The American journal of pathology\| PubMed ID: 32958140	2020

Article	Year
Challenges in IBD Research: Update on Progress and Prioritization of the CCFA's Research Agenda. Inflammatory bowel diseases\| PubMed ID: 23448796	2013
Junctional adhesion molecule A promotes epithelial tight junction assembly to augment lung barrier function. The American journal of pathology\| PubMed ID: 25438062	2015
Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. The Journal of clinical investigation\| PubMed ID: 25664854	2015
HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation. The American journal of pathology\| PubMed ID: 26216285	2015
Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier. Molecular biology of the cell\| PubMed ID: 26224314	2015
Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26590314	2016
Targeting of Neutrophil Lewis X Blocks Transepithelial Migration and Increases Phagocytosis and Degranulation. The American journal of pathology\| PubMed ID: 26687991	2016
Neutrophil-Epithelial Interactions: A Double-Edged Sword. The American journal of pathology\| PubMed ID: 27083514	2016
Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol. Gastroenterology\| PubMed ID: 27342212	2016
Redox control of Cas phosphorylation requires Abl kinase in regulation of intestinal epithelial cell spreading and migration. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 27418680	2016
Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair. Gastroenterology\| PubMed ID: 27436072	2016
Deposition of microparticles by neutrophils onto inflamed epithelium: a new mechanism to disrupt epithelial intercellular adhesions and promote transepithelial migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 27553226	2016
Pathobiology of neutrophil-epithelial interactions. Immunological reviews\| PubMed ID: 27558330	2016
Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascades. Tissue barriers\| PubMed ID: 27583195	2016
IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria. Mucosal immunology\| PubMed ID: 27624780	2017
Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE. Journal of leukocyte biology\| PubMed ID: 27965383	2017
Expression of Lewis-a glycans on polymorphonuclear leukocytes augments function by increasing transmigration. Journal of leukocyte biology\| PubMed ID: 28600306	2017
Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling. The Journal of clinical investigation\| PubMed ID: 28783045
Role of negative regulation of immune signaling pathways in neutrophil function. Journal of leukocyte biology\| PubMed ID: 29345376	2017
Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines. Cell death & disease\| PubMed ID: 29523777
Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to . Frontiers in immunology\| PubMed ID: 29881378	2018
Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model. JCI insight\| PubMed ID: 30333307	2018
Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation. Molecular biology of the cell\| PubMed ID: 30625033	2019
Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice. Mucosal immunology\| PubMed ID: 30745566	2019
Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8 T-Cell Activation. Frontiers in immunology\| PubMed ID: 30936879	2019
TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium. Mucosal immunology\| PubMed ID: 30971752
Innate immune cell-epithelial crosstalk during wound repair. The Journal of clinical investigation\| PubMed ID: 31329162	2019
Formyl peptide receptor 2 regulates monocyte recruitment to promote intestinal mucosal wound repair. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31585047
Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo. Nature communications\| PubMed ID: 31676794
Regulation of neutrophil function by selective targeting of glycan epitopes expressed on the integrin CD11b/CD18. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31907993	2020
Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration. Molecular biology of the cell\| PubMed ID: 31967937	2020
Western diet-induced increase in colonic bile acids compromises epithelial barrier in nonalcoholic steatohepatitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32275114	2020
Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32300016
Targeting epithelial expressed Sialyl Lewis glycans improves colonic mucosal wound healing and protects against colitis. JCI insight\| PubMed ID: 32427587
Blocking integrin αβ-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis. Journal of hepatology\| PubMed ID: 32540177	2020
Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo. Mucosal immunology\| PubMed ID: 32561828	2020
Dysregulation of intestinal epithelial CFTR-dependent Cl ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice. Mucosal immunology\| PubMed ID: 32576925	2021
WD40 Repeat Protein 26 Negatively Regulates Formyl Peptide Receptor-1 Mediated Wound Healing in Intestinal Epithelial Cells. The American journal of pathology\| PubMed ID: 32958140	2020