Sanjiv S. Gambhir

Comparison of [18F]FHBG and [14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs stable transfection.

Optimization of adenoviral vectors to direct highly amplified prostate-specific expression for imaging and gene therapy.

Synthesis of a new heterobifunctional linker, N-[4-(aminooxy)butyl]maleimide, for facile access to a thiol-reactive 18F-labeling agent.

124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice.

Imaging tri-fusion multimodality reporter gene expression in living subjects.

Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications.

Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery.

Molecular imaging of drug-modulated protein-protein interactions in living subjects.

Tetraphenylphosphonium as a novel molecular probe for imaging tumors.

Molecular imaging of homodimeric protein-protein interactions in living subjects.

Quantitation of cell number by a positron emission tomography reporter gene strategy.

Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors.

Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expression.

Molecular imaging of cardiovascular gene products.

Molecular imaging of the kinetics of vascular endothelial growth factor gene expression in ischemic myocardium.

Noninvasive imaging of enhanced prostate-specific gene expression using a two-step transcriptional amplification-based lentivirus vector.

A tracer kinetic model for 18F-FHBG for quantitating herpes simplex virus type 1 thymidine kinase reporter gene expression in living animals using PET.

Multimodality imaging of lymphocytic migration using lentiviral-based transduction of a tri-fusion reporter gene.

PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene.

Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography.

Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments.

Firefly luciferase enzyme fragment complementation for imaging in cells and living animals.

FDG-PET and beyond: molecular breast cancer imaging.

Noninvasive monitoring of target gene expression by imaging reporter gene expression in living animals using improved bicistronic vectors.

A new strategy to screen molecular imaging probe uptake in cell culture without radiolabeling using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Functionality of androgen receptor-based gene expression imaging in hormone refractory prostate cancer.

Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients.

Noninvasive imaging of ex vivo intracoronarily delivered nonviral therapeutic transgene expression in heart.

Bioluminescent imaging of melanoma in live mice.

Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging.

Comparison of [14C]FMAU, [3H]FEAU, [14C]FIAU, and [3H]PCV for monitoring reporter gene expression of wild type and mutant herpes simplex virus type 1 thymidine kinase in cell culture.

Novel fusion protein approach for efficient high-throughput screening of small molecule-mediating protein-protein interactions in cells and living animals.

Gene therapy imaging in patients for oncological applications.

microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide.

Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging.

Clinical molecular imaging and therapy-moving ahead together.

Small animal imaging center design: the facility at the UCLA Crump Institute for Molecular Imaging.

Reproducibility of 3'-deoxy-3'-(18)F-fluorothymidine microPET studies in tumor xenografts in mice.

Imaging androgen receptor function during flutamide treatment in the LAPC9 xenograft model.

Micro-PET/CT monitoring of herpes thymidine kinase suicide gene therapy in a prostate cancer xenograft: the advantage of a cell-specific transcriptional targeting approach.

Visualization of a primary anti-tumor immune response by positron emission tomography.

Studying molecular and cellular processes in the intact organism.

Transcriptional profiling of reporter genes used for molecular imaging of embryonic stem cell transplantation.

Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2.

Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene.

Bioluminescence imaging of systemic tumor targeting using a prostate-specific lentiviral vector.

Noninvasive indirect imaging of vascular endothelial growth factor gene expression using bioluminescence imaging in living transgenic mice.

Visualization of telomerase reverse transcriptase (hTERT) promoter activity using a trimodality fusion reporter construct.

Applications of molecular imaging in cancer gene therapy.

In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery.

Self-illuminating quantum dot conjugates for in vivo imaging.

Monitoring the antitumor response of naive and memory CD8 T cells in RAG1-/- mice by positron-emission tomography.

Noninvasive evaluation of immunosuppressive drug efficacy on acute donor cell survival.

Preclinical safety evaluation of 18F-FHBG: a PET reporter probe for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk's expression.

Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.

Significance of one-bead-one-compound combinational chemistry.

Evaluation of firefly luciferase bioluminescence mediated photodynamic toxicity in cancer cells.

HaloTag protein-mediated site-specific conjugation of bioluminescent proteins to quantum dots.

"Flying through" and "flying around" a PET/CT scan: Pilot study and development of 3D integrated 18F-FDG PET/CT for virtual bronchoscopy and colonoscopy.

Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat hearts.

Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts.

Bifunctional antibody-Renilla luciferase fusion protein for in vivo optical detection of tumors.

F-18 fluorodeoxyglucose PET/CT as an imaging tool for staging and restaging cutaneous angiosarcoma of the scalp.

F-18 FDG PET/CT imaging of extramammary Paget disease of the perianal region.

An intramolecular folding sensor for imaging estrogen receptor-ligand interactions.

Imaging mitogen-activated protein kinase function in xenograft models of prostate cancer.

F-18 FDG PET/CT evaluation of osseous and soft tissue sarcomas.

How molecular imaging is speeding up antiangiogenic drug development.

PET of vascular endothelial growth factor receptor expression.

Impact of integrated PET/CT on variability of target volume delineation in rectal cancer.

Reporter gene imaging of protein-protein interactions in living subjects.

Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging.

PET imaging of colorectal cancer in xenograft-bearing mice by use of an 18F-labeled T84.66 anti-carcinoembryonic antigen diabody.

Evaluation of herpes simplex virus 1 thymidine kinase-mediated trapping of (131)I FIAU and prodrug activation of ganciclovir as a synergistic cancer radio/chemotherapy.

Combinatorial library screening for developing an improved split-firefly luciferase fragment-assisted complementation system for studying protein-protein interactions.

In vivo bioluminescence tumor imaging of RGD peptide-modified adenoviral vector encoding firefly luciferase reporter gene.

In vivo optical bioluminescence imaging of collagen-supported cardiac cell grafts.

Reproducibility of 18F-FDG microPET studies in mouse tumor xenografts.

Integrating noninvasive molecular imaging into molecular medicine: an evolving paradigm.

Creating self-illuminating quantum dot conjugates.

PET imaging of herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk reporter gene expression in mice and humans using [18F]FHBG.

Measuring herpes simplex virus thymidine kinase reporter gene expression in vitro.

Molecular imaging: the vision and opportunity for radiology in the future.

Fusion of Gaussia luciferase to an engineered anti-carcinoembryonic antigen (CEA) antibody for in vivo optical imaging.

Cardiovascular molecular imaging.

Studying the biodistribution of positron emission tomography reporter probes in mice.

microPET-based biodistribution of quantum dots in living mice.

Molecular imaging: integration of molecular imaging into the musculoskeletal imaging practice.

Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease.

Quantum dot imaging for embryonic stem cells.

Molecular imaging techniques in body imaging.

Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature.

Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis.

Regulatory and reimbursement challenges for molecular imaging.

BRET-based method for detection of specific RNA species.

Preclinical efficacy of the c-Met inhibitor CE-355621 in a U87 MG mouse xenograft model evaluated by 18F-FDG small-animal PET.

Molecular imaging of reporter gene expression in prostate cancer: an overview.

The synthesis of 18F-FDS and its potential application in molecular imaging.

Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression.

US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice.

Monitoring of the biological response to murine hindlimb ischemia with 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography.

Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice.

A human estrogen receptor (ER)alpha mutation with differential responsiveness to nonsteroidal ligands: novel approaches for studying mechanism of ER action.

Direct site-specific radiolabeling of an Affibody protein with 4-[18F]fluorobenzaldehyde via oxime chemistry.

A generalizable strategy for imaging pre-mRNA levels in living subjects using spliceosome-mediated RNA trans-splicing.

Cell-free metabolic engineering promotes high-level production of bioactive Gaussia princeps luciferase.

Molecular imaging in drug development.

Molecular imaging of PET reporter gene expression.

Drug delivery: keeping tabs on nanocarriers.

A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice.

Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice.

Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo.

Cancer screening: a mathematical model relating secreted blood biomarker levels to tumor sizes.

Noninvasive imaging of therapeutic gene expression using a bidirectional transcriptional amplification strategy.

Carbon nanotubes as photoacoustic molecular imaging agents in living mice.

Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes.

Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells.

Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG PET in a patient with glioma.

Chapter 7. Molecular imaging of tumor vasculature.

Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation.

Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice.

Use of bioluminescent imaging to assay the transplantation of immortalized human fetal hepatocytes into mice.

Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice.

Protein-functionalized synthetic antiferromagnetic nanoparticles for biomolecule detection and magnetic manipulation.

Endogenous NIS expression in triple-negative breast cancers.

A novel method for direct site-specific radiolabeling of peptides using [18F]FDG.

A novel high-sensitivity rapid-acquisition single-photon cardiac imaging camera.

Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells.

A potent, imaging adenoviral vector driven by the cancer-selective mucin-1 promoter that targets breast cancer metastasis.

Imaging gene expression in human mesenchymal stem cells: from small to large animals.

Engineered two-helix small proteins for molecular recognition.

Simulations of virtual PET/CT 3-D bronchoscopy imaging using a physical porcine lung-heart phantom.

Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging.

Efficacy of 18F-FDG PET/CT in the evaluation of patients with recurrent cervical carcinoma.

Cys-diabody quantum dot conjugates (immunoQdots) for cancer marker detection.

A novel estrogen receptor intramolecular folding-based titratable transgene expression system.

Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy.

Visualizing implanted tumors in mice with magnetic resonance imaging using magnetotactic bacteria.

A 2-helix small protein labeled with 68Ga for PET imaging of HER2 expression.

Meta-analysis of the performance of (18)F-FDG PET in cutaneous melanoma.

Melanin-targeted preclinical PET imaging of melanoma metastasis.

A strategy for blood biomarker amplification and localization using ultrasound.

Matrix-insensitive protein assays push the limits of biosensors in medicine.

PET of malignant melanoma using 18F-labeled metallopeptides.

18F-FDG uptake in lung, breast, and colon cancers: molecular biology correlates and disease characterization.

Three-dimensional photoacoustic imaging using a two-dimensional CMUT array.

Combined 18F-FDG and Fluoride Approach in PET/CT Imaging: Is There a Clinical Future?

Antioxidants improve early survival of cardiomyoblasts after transplantation to the myocardium.

Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction.

Whole-body, real-time preclinical imaging of quantum dot fluorescence with time-gated detection.

A Dual-Labeled Knottin Peptide for PET and Near-Infrared Fluorescence Imaging of Integrin Expression in Living Subjects.

Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast microbubbles conjugated to integrin-binding knottin peptides.

Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion.

Molecular optical imaging with radioactive probes.

Antiangiogenic cancer therapy: monitoring with molecular US and a clinically translatable contrast agent (BR55).

Molecular imaging using light-absorbing imaging agents and a clinical optical breast imaging system--a phantom study.

Facile synthesis, silanization, and biodistribution of biocompatible quantum dots.

Implantable semiconductor biosensor for continuous in vivo sensing of far-red fluorescent molecules.

Assessing delivery and quantifying efficacy of small interfering ribonucleic acid therapeutics in the skin using a dual-axis confocal microscope.

Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemia.

A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography.

Noninvasive molecular imaging of c-Myc activation in living mice.

PET imaging of tumor neovascularization in a transgenic mouse model with a novel 64Cu-DOTA-knottin peptide.

Oxidative stress mediates the effects of Raman-active gold nanoparticles in human cells.

Reproducibility study of [(18)F]FPP(RGD)2 uptake in murine models of human tumor xenografts.

Affibody-based nanoprobes for HER2-expressing cell and tumor imaging.

Longitudinal, noninvasive imaging of T-cell effector function and proliferation in living subjects.

Non-invasive bioluminescence imaging of myoblast-mediated hypoxia-inducible factor-1 alpha gene transfer.

Noninvasive monitoring of placenta-specific transgene expression by bioluminescence imaging.

Affibody-functionalized gold-silica nanoparticles for Raman molecular imaging of the epidermal growth factor receptor.

"Same day" ex-vivo regional gene therapy: a novel strategy to enhance bone repair.

Engineering and visualization of bacteria for targeting infarcted myocardium.

Use of DNA microarray and small animal positron emission tomography in preclinical drug evaluation of RAF265, a novel B-Raf/VEGFR-2 inhibitor.

First experience with clinical-grade ([¹⁸F]FPP(RGD₂): an automated multi-step radiosynthesis for clinical PET studies.

Pilot pharmacokinetic and dosimetric studies of (18)F-FPPRGD2: a PET radiopharmaceutical agent for imaging α(v)β(3) integrin levels.

Early diagnosis of ovarian carcinoma: is a solution in sight?

The fate and toxicity of Raman-active silica-gold nanoparticles in mice.

Preclinical evaluation of Raman nanoparticle biodistribution for their potential use in clinical endoscopy imaging.

Adipose tissue-derived stem cells display a proangiogenic phenotype on 3D scaffolds.

Nanoparticle PEGylation for imaging and therapy.

Preclinical derivation and imaging of autologously transplanted canine induced pluripotent stem cells.

Bioluminescence resonance energy transfer (BRET) imaging of protein-protein interactions within deep tissues of living subjects.

A novel 18F-labeled two-helix scaffold protein for PET imaging of HER2-positive tumor.

Immobilizing reporters for molecular imaging of the extracellular microenvironment in living animals.

Endothelial cells derived from human iPSCS increase capillary density and improve perfusion in a mouse model of peripheral arterial disease.

Raman's "effect" on molecular imaging.

Response to Intra-Arterial Oncolytic Virotherapy with the Herpes Virus NV1020 Evaluated by [(18)F]Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography.

Molecular imaging with theranostic nanoparticles.

Noninvasive cell-tracking methods.

In vivo targeting of HER2-positive tumor using 2-helix affibody molecules.

Theranostic nanomedicine.

Advanced contrast nanoagents for photoacoustic molecular imaging, cytometry, blood test and photothermal theranostics.

In vitro and in vivo molecular imaging of estrogen receptor α and β homo- and heterodimerization: exploration of new modes of receptor regulation.

GLUT 5 is not over-expressed in breast cancer cells and patient breast cancer tissues.

Mathematical model identifies blood biomarker-based early cancer detection strategies and limitations.

MC3T3-E1 Osteoprogenitor Cells Systemically Migrate to a Bone Defect and Enhance Bone Healing.

A novel clinically translatable fluorescent nanoparticle for targeted molecular imaging of tumors in living subjects.

Pharmacokinetically Stabilized Cystine Knot Peptides That Bind Alpha-v-Beta-6 Integrin with Single-Digit Nanomolar Affinities for Detection of Pancreatic Cancer.

Optical imaging with her2-targeted affibody molecules can monitor hsp90 treatment response in a breast cancer xenograft mouse model.