Diane Crighton

RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome.

Several regions of p53 are involved in repression of RNA polymerase III transcription.

p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB.

Splicing DNA-damage responses to tumour cell death.

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.

DRAM links autophagy to p53 and programmed cell death.

A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.

p53-mediated induction of Noxa and p53AIP1 requires NFkappaB.

Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B.

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival.

Trailblazing LIM kinases take the lead in collective tumor cell invasion.

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.