BHF Centre of Research Excellence,
Division of Cardiovascular Medicine,
Radcliffe Department of Medicine,
John Radcliffe Hospital,
Wellcome Centre for Human Genetics,
BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital
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Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
The Journal of biological chemistry Jan, 2009 | Pubmed ID: 19011239
GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
The Journal of biological chemistry May, 2009 | Pubmed ID: 19286659
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
The Journal of biological chemistry Oct, 2009 | Pubmed ID: 19666465
Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
Free radical biology & medicine Jun, 2011 | Pubmed ID: 21402147
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
Nitric oxide : biology and chemistry Aug, 2011 | Pubmed ID: 21550412
Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice.
Cardiovascular research Apr, 2012 | Pubmed ID: 22287576
Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.
Circulation Mar, 2012 | Pubmed ID: 22315282
Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling.
Current heart failure reports Sep, 2012 | Pubmed ID: 22711313
Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.
Circulation research Aug, 2012 | Pubmed ID: 22798524
Nitric oxide synthases in heart failure.
Antioxidants & redox signaling Mar, 2013 | Pubmed ID: 22871241
Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification.
European heart journal Sep, 2012 | Pubmed ID: 23008511
Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms.
The Journal of biological chemistry Dec, 2012 | Pubmed ID: 23091050
Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
The Journal of biological chemistry Jan, 2013 | Pubmed ID: 23139420
A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.
The Journal of biological chemistry Oct, 2013 | Pubmed ID: 23965989
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.
Free radical biology & medicine Feb, 2014 | Pubmed ID: 24148766
Tetrahydrobiopterin in cardiovascular health and disease.
Antioxidants & redox signaling Jun, 2014 | Pubmed ID: 24294830
Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Hypertension (Dallas, Tex. : 1979) Sep, 2014 | Pubmed ID: 24777984
Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection.
Circulation Jun, 2014 | Pubmed ID: 24807872
Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
Brain : a journal of neurology May, 2015 | Pubmed ID: 25398233
Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
Free radical biology & medicine Feb, 2015 | Pubmed ID: 25451639
A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
Developmental biology Mar, 2015 | Pubmed ID: 25557619
CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension.
Hypertension (Dallas, Tex. : 1979) Jun, 2015 | Pubmed ID: 25916729
Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide.
The Journal of physiology 07, 2016 | Pubmed ID: 26752781
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.
Free radical biology & medicine 03, 2017 | Pubmed ID: 28104455
A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.
British journal of pharmacology 04, 2017 | Pubmed ID: 28128438
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Cardiovascular research 08, 2018 | Pubmed ID: 29596571
Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation.
Scientific reports 09, 2018 | Pubmed ID: 30254268
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.
Nature communications 12, 2018 | Pubmed ID: 30573728
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Cell reports 07, 2019 | Pubmed ID: 31269442
Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology.
Nitric oxide : biology and chemistry 08, 2020 | Pubmed ID: 32339668
Atrial nitroso-redox balance and refractoriness following on-pump cardiac surgery: a randomized trial of atorvastatin.
Cardiovascular research 01, 2022 | Pubmed ID: 33098411
Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis.
Circulation 09, 2021 | Pubmed ID: 34255973
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity.
Gastroenterology 12, 2021 | Pubmed ID: 34425095
Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine.
Biochemical Society transactions 11, 2021 | Pubmed ID: 34665229
Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth.
Hypertension (Dallas, Tex. : 1979) 12, 2021 | Pubmed ID: 34689592
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