College of Pharmacy
Professor of Pharmacology, majoring in the research of metabolic disease pharmacology.
Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits.
The American journal of pathology Oct, 2004 | Pubmed ID: 15466401
Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1.
Scientific reports 06, 2016 | Pubmed ID: 27329817
Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis.
Arthritis and rheumatism Oct, 2004 | Pubmed ID: 15476203
C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance.
The American journal of pathology Oct, 2005 | Pubmed ID: 16192648
Increased expression of human macrophage metalloelastase (MMP-12) is associated with the invasion of endometrial adenocarcinoma.
Pathology, research and practice , 2007 | Pubmed ID: 17574772
Protective effect of JBP485 on concanavalin A-induced hepatocyte toxicity in primary cultured rat hepatocytes.
European journal of pharmacology Jul, 2008 | Pubmed ID: 18571156
Laennec protects murine from concanavalin A-induced liver injury through inhibition of inflammatory reactions and hepatocyte apoptosis.
Biological & pharmaceutical bulletin Nov, 2008 | Pubmed ID: 18981570
Pharmacokinetic interaction between JBP485 and cephalexin in rats.
Drug metabolism and disposition: the biological fate of chemicals Jun, 2010 | Pubmed ID: 20219852
Molecular mechanisms of biliary excretion of cefditoren and the effects of cefditoren on the expression levels of hepatic transporters.
Drug metabolism and pharmacokinetics , 2010 | Pubmed ID: 20814152
Peptide cotransporter 1 in intestine and organic anion transporters in kidney are targets of interaction between JBP485 and lisinopril in rats.
Drug metabolism and pharmacokinetics , 2012 | Pubmed ID: 22123131
Subchronic toxicity study of the total flavonoids from Rosa laevigata Michx fruit in rats.
Regulatory toxicology and pharmacology : RTP Mar, 2012 | Pubmed ID: 22226919
Organic anion transporters involved in the excretion of bestatin in the kidney.
Peptides Feb, 2012 | Pubmed ID: 22273603
Construction, identification and application of HeLa cells stably transfected with human PEPT1 and PEPT2.
Peptides Apr, 2012 | Pubmed ID: 22369721
Effect of JBP485 on obstructive jaundice is related to regulation of renal Oat1, Oat3 and Mrp2 expression in ANIT-treated rats.
Peptides Jul, 2012 | Pubmed ID: 22521734
Inhibitory effect of JBP485 on renal excretion of acyclovir by the inhibition of OAT1 and OAT3.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Sep, 2012 | Pubmed ID: 22728397
Changes in expression of renal Oat1, Oat3 and Mrp2 in cisplatin-induced acute renal failure after treatment of JBP485 in rats.
Toxicology and applied pharmacology Nov, 2012 | Pubmed ID: 22992436
Inhibitory effect of 1α,25-dihydroxyvitamin D₃ on excretion of JBP485 via organic anion transporters in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jan, 2013 | Pubmed ID: 23201003
OAT1 and OAT3: targets of drug-drug interaction between entecavir and JBP485.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Mar, 2013 | Pubmed ID: 23313623
Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans.
Drug metabolism and disposition: the biological fate of chemicals May, 2013 | Pubmed ID: 23396419
Dioscin Restores the Activity of the Anticancer Agent Adriamycin in Multidrug-Resistant Human Leukemia K562/Adriamycin Cells by Down-Regulating MDR1 via a Mechanism Involving NF-κB Signaling Inhibition.
Journal of natural products May, 2013 | Pubmed ID: 23621869
JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats.
Toxicology and applied pharmacology May, 2013 | Pubmed ID: 23707770
Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3.
Pharmacological reports : PR , 2013 | Pubmed ID: 23744435
Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Sep, 2013 | Pubmed ID: 23764357
Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Nov, 2013 | Pubmed ID: 23981338
The oligopeptide transporter 2-mediated reabsorption of entecavir in rat kidney.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Feb, 2014 | Pubmed ID: 24184752
MDR1 and OAT1/OAT3 mediate the drug-drug interaction between puerarin and methotrexate.
Pharmaceutical research May, 2014 | Pubmed ID: 24242937
Inhibitory effect of valsartan on the intestinal absorption and renal excretion of bestatin in rats.
Journal of pharmaceutical sciences Feb, 2014 | Pubmed ID: 24338900
Methotrexate-bestatin interaction: involvement of P-glycoprotein and organic anion transporters in rats.
International journal of pharmaceutics Apr, 2014 | Pubmed ID: 24530518
Luteolin protects HUVECs from TNF-α-induced oxidative stress and inflammation via its effects on the Nox4/ROS-NF-κB and MAPK pathways.
Journal of atherosclerosis and thrombosis , 2014 | Pubmed ID: 24621786
Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo.
Toxicology and applied pharmacology Jun, 2014 | Pubmed ID: 24680847
Aspirin and probenecid inhibit organic anion transporter 3-mediated renal uptake of cilostazol and probenecid induces metabolism of cilostazol in the rat.
Drug metabolism and disposition: the biological fate of chemicals Jun, 2014 | Pubmed ID: 24692216
Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.
Journal of biomedical science Apr, 2014 | Pubmed ID: 24742230
OATP and MRP2-mediated hepatic uptake and biliary excretion of eprosartan in rat and human.
Pharmacological reports : PR Apr, 2014 | Pubmed ID: 24911086
PEPT1- and OAT1/3-mediated drug-drug interactions between bestatin and cefixime in vivo and in vitro in rats, and in vitro in human.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Oct, 2014 | Pubmed ID: 25016073
Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice.
Pharmaceutical research Feb, 2015 | Pubmed ID: 25143196
Alisol B 23-acetate promotes liver regeneration in mice after partial hepatectomy via activating farnesoid X receptor.
Biochemical pharmacology Nov, 2014 | Pubmed ID: 25278094
Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway.
Toxicology letters Jan, 2015 | Pubmed ID: 25305479
Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-κ B and PI3K/Akt pathways.
Current pharmaceutical biotechnology , 2014 | Pubmed ID: 25391245
Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway.
Cancer biology & therapy , 2015 | Pubmed ID: 25482933
Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-α-induced VCAM-1, ICAM-1and EL expression via the NF-κB pathway.
Biochimie Mar, 2015 | Pubmed ID: 25577996
Potent effects of dioscin against obesity in mice.
Scientific reports Jan, 2015 | Pubmed ID: 25609476
Decreased liver distribution of entecavir is related to down-regulation of Oat2/Oct1 and up-regulation of Mrp1/2/3/5 in rat liver fibrosis.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Apr, 2015 | Pubmed ID: 25712368
Protective effects of alisol B 23-acetate from edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice.
Food & function Apr, 2015 | Pubmed ID: 25747392
Potent effects of dioscin against liver fibrosis.
Scientific reports Apr, 2015 | Pubmed ID: 25853178
Protective Effects of Alisol B 23-Acetate Via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Estrogen-Induced Cholestatic Liver Injury in Mice.
Pharmaceutical research Nov, 2015 | Pubmed ID: 26040663
Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70.
Pharmacological research Oct, 2015 | Pubmed ID: 26348276
Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro.
International journal of pharmaceutics Nov, 2015 | Pubmed ID: 26394120
Bezafibrate-mizoribine interaction: Involvement of organic anion transporters OAT1 and OAT3 in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jan, 2016 | Pubmed ID: 26474691
Targeting P-glycoprotein expression and cancer cell energy metabolism: combination of metformin and 2-deoxyglucose reverses the multidrug resistance of K562/Dox cells to doxorubicin.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Jul, 2016 | Pubmed ID: 26733176
Chondroprotective effects of alpha-lipoic acid in a rat model of osteoarthritis.
Free radical research Jul, 2016 | Pubmed ID: 27055478
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie May, 2016 | Pubmed ID: 27133040
Dioscin reduces ovariectomy-induced bone loss by enhancing osteoblastogenesis and inhibiting osteoclastogenesis.
Pharmacological research 06, 2016 | Pubmed ID: 27155058
Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.
Toxicology and applied pharmacology 08, 2016 | Pubmed ID: 27317372
P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate.
Toxicology and applied pharmacology 09, 2016 | Pubmed ID: 27377006
Dioscin alleviates lipopolysaccharide-induced inflammatory kidney injury via the microRNA let-7i/TLR4/MyD88 signaling pathway.
Pharmacological research 09, 2016 | Pubmed ID: 27431331
Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice.
Food & function Sep, 2016 | Pubmed ID: 27487733
Design and synthesis of phosphoryl-substituted diphenylpyrimidines (Pho-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors: Targeted treatment of B lymphoblastic leukemia cell lines.
Bioorganic & medicinal chemistry 01, 2017 | Pubmed ID: 27956037
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Oncotarget Jan, 2017 | Pubmed ID: 28052008
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Phytomedicine : international journal of phytotherapy and phytopharmacology Feb, 2017 | Pubmed ID: 28190475
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
Frontiers in pharmacology , 2017 | Pubmed ID: 28377715
Targeting Oct2 and P53: Formononetin prevents cisplatin-induced acute kidney injury.
Toxicology and applied pharmacology 07, 2017 | Pubmed ID: 28414026
Protective effects of glycyrrhizic acid against non-alcoholic fatty liver disease in mice.
European journal of pharmacology Jul, 2017 | Pubmed ID: 28414056
Organic Anion-Transporting Polypeptide and Efflux Transporter-Mediated Hepatic Uptake and Biliary Excretion of Cilostazol and Its Metabolites in Rats and Humans.
Journal of pharmaceutical sciences 09, 2017 | Pubmed ID: 28535976
Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.
Journal of cellular physiology 04, 2018 | Pubmed ID: 28681913
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
Journal of gastroenterology and hepatology Feb, 2018 | Pubmed ID: 28699662
Computational discovery and experimental verification of farnesoid X receptor agonist auraptene to protect against cholestatic liver injury.
Biochemical pharmacology 12, 2017 | Pubmed ID: 28987596
OAT1 and OAT3 also mediate the drug-drug interaction between piperacillin and tazobactam.
International journal of pharmaceutics Feb, 2018 | Pubmed ID: 29277663
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Pharmacological research 04, 2018 | Pubmed ID: 29284152
Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway.
Free radical research Feb, 2018 | Pubmed ID: 29400110
Protective effects of yangonin from an edible botanical Kava against lithocholic acid-induced cholestasis and hepatotoxicity.
European journal of pharmacology Apr, 2018 | Pubmed ID: 29427579
P-gp is involved in the intestinal absorption and biliary excretion of afatinib in vitro and in rats.
Pharmacological reports : PR Apr, 2018 | Pubmed ID: 29475007
Yangonin protects against cholestasis and hepatotoxity via activation of farnesoid X receptor in vivo and in vitro.
Toxicology and applied pharmacology 06, 2018 | Pubmed ID: 29660435
Icariin promotes stable chondrogenic differentiation of bone marrow mesenchymal stem cells in self‑assembling peptide nanofiber hydrogel scaffolds.
Molecular medicine reports Jun, 2018 | Pubmed ID: 29693145
Puerarin improves methotrexate-induced renal damage by up-regulating renal expression of Oat1 and Oat3 in vivo and in vitro.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Jul, 2018 | Pubmed ID: 29710508
Hepatoprotection of auraptene from peels of citrus fruits against thioacetamide-induced hepatic fibrosis in mice by activating farnesoid X receptor.
Food & function May, 2018 | Pubmed ID: 29721568
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway.
International immunopharmacology Aug, 2018 | Pubmed ID: 29902710
MicroRNA-351-5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and Sirtuin-6.
British journal of pharmacology 09, 2018 | Pubmed ID: 29952043
JBP485 attenuates vancomycin-induced nephrotoxicity by regulating the expressions of organic anion transporter (Oat) 1, Oat3, organic cation transporter 2 (Oct2), multidrug resistance-associated protein 2 (Mrp2) and P-glycoprotein (P-gp) in rats.
Toxicology letters Oct, 2018 | Pubmed ID: 29964132
Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride-induced acute liver injury by activating Nrf2 signaling pathway in mice.
Environmental toxicology Oct, 2018 | Pubmed ID: 29964319
Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2018 | Pubmed ID: 29975924
Novel amino acid-substituted diphenylpyrimidine derivatives as potent BTK inhibitors against B cell lymphoma cell lines.
Bioorganic & medicinal chemistry 08, 2018 | Pubmed ID: 30006143
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Regulatory toxicology and pharmacology : RTP Oct, 2018 | Pubmed ID: 30030101
Structural optimization of diphenylpyrimidine scaffold as potent and selective epidermal growth factor receptor inhibitors against L858R/T790M resistance mutation in nonsmall cell lung cancer.
Chemical biology & drug design 12, 2018 | Pubmed ID: 30030903
Hepatoprotective effect of rhein against methotrexate-induced liver toxicity.
European journal of pharmacology Sep, 2018 | Pubmed ID: 30031796
Activating the PGC-1/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.
Oxidative medicine and cellular longevity , 2018 | Pubmed ID: 30046372
Pharmacokinetic changes of cefdinir and cefditoren and its molecular mechanisms in acute kidney injury in rats.
The Journal of pharmacy and pharmacology Nov, 2018 | Pubmed ID: 30047127
Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Oct, 2018 | Pubmed ID: 30119251
Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.
Journal of cellular physiology 04, 2019 | Pubmed ID: 30171603
Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro.
Journal of cellular physiology 04, 2019 | Pubmed ID: 30192012
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Inflammation Feb, 2019 | Pubmed ID: 30315526
Protective effects of dioscin against cartilage destruction in a monosodium iodoacetate (MIA)-indcued osteoarthritis rat model.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Dec, 2018 | Pubmed ID: 30372803
Targeting P-Glycoprotein: Nelfinavir Reverses Adriamycin Resistance in K562/ADR Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2018 | Pubmed ID: 30497065
miR-125a-5p ameliorates hepatic glycolipid metabolism disorder in type 2 diabetes mellitus through targeting of STAT3.
Theranostics , 2018 | Pubmed ID: 30555566
Resveratrol enhances the protective effects of JBP485 against indomethacin-induced rat intestinal damage in vivo and vitro through up-regulating oligopeptide transporter 1 (Pept1).
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Mar, 2019 | Pubmed ID: 30590313
Yangonin protects against non-alcoholic fatty liver disease through farnesoid X receptor.
Phytomedicine : international journal of phytotherapy and phytopharmacology Feb, 2019 | Pubmed ID: 30668392
Facile synthesis of fluorescent carbon dots from Prunus cerasifera fruits for fluorescent ink, Fe ion detection and cell imaging.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Apr, 2019 | Pubmed ID: 30703711
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
British journal of pharmacology 04, 2019 | Pubmed ID: 30710454
Rosmarinic acid exerts an antagonistic effect on vascular calcification by regulating the Nrf2 signalling pathway.
Free radical research Feb, 2019 | Pubmed ID: 30864863
Scutellarin exerts protective effects against atherosclerosis in rats by regulating the Hippo-FOXO3A and PI3K/AKT signaling pathways.
Journal of cellular physiology 08, 2019 | Pubmed ID: 30891776
Hepatoprotection of auraptene from the peels of citrus fruits against 17α-ethinylestradiol-induced cholestasis in mice by activating farnesoid X receptor.
Food & function Jul, 2019 | Pubmed ID: 31210195
An interspecies study of lipid profiles and atherosclerosis in familial hypercholesterolemia animal models with low-density lipoprotein receptor deficiency.
American journal of translational research , 2019 | Pubmed ID: 31217881
Yangonin protects against estrogen-induced cholestasis in a farnesoid X receptor-dependent manner.
European journal of pharmacology Aug, 2019 | Pubmed ID: 31220436
Catalpol alleviates adriamycin-induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro.
British journal of pharmacology 12, 2019 | Pubmed ID: 31378931
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
Pharmacological research 10, 2019 | Pubmed ID: 31449974
Hepatoprotection of yangonin against hepatic fibrosis in mice via farnesoid X receptor activation.
International immunopharmacology Oct, 2019 | Pubmed ID: 31450152
Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein.
Journal of cellular physiology 04, 2020 | Pubmed ID: 31587272
Cilastatin protects against imipenem-induced nephrotoxicity inhibition of renal organic anion transporters (OATs).
Acta pharmaceutica Sinica. B Sep, 2019 | Pubmed ID: 31649848
Corrigendum to "Dioscin attenuates renal ischemia/reperfusion injury by inhibiting theTLR4/MyD88 signaling pathway via up-regulation of HSP70" [Pharmacol. Res. 100 (2015) 341-352].
Pharmacological research Dec, 2019 | Pubmed ID: 31699473
Biomineralized Gd O @HSA Nanoparticles as a Versatile Platform for Dual-Modal Imaging and Chemo-Phototherapy-Synergized Tumor Ablation.
Advanced healthcare materials 12, 2019 | Pubmed ID: 31738019
Corrigendum to "Dioscin reduces ovariectomy-induced bone loss by enhancing osteoblastogenesis and inhibiting osteoclastogenesis" [Pharmacol. Res. 108 (2016) 90-101].
Pharmacological research Jan, 2020 | Pubmed ID: 31780339
Synthesis and biological activity of thieno[3,2-d]pyrimidines as potent JAK3 inhibitors for the treatment of idiopathic pulmonary fibrosis.
Bioorganic & medicinal chemistry 01, 2020 | Pubmed ID: 31866272
Corrigendum to "Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis" [Pharmacol. Res. 148 (2019) 104414].
Pharmacological research Mar, 2020 | Pubmed ID: 31926782
Protective effect of cilastatin against diclofenac-induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters.
British journal of pharmacology 05, 2020 | Pubmed ID: 32000294
Targeting of miR-96-5p by catalpol ameliorates oxidative stress and hepatic steatosis in LDLr-/- mice via p66shc/cytochrome C cascade.
Aging 02, 2020 | Pubmed ID: 32023549
Piperacillin enhances the inhibitory effect of tazobactam on β-lactamase through inhibition of organic anion transporter 1/3 in rats.
Asian journal of pharmaceutical sciences Nov, 2019 | Pubmed ID: 32104494
Macrophage-derived MMP-9 enhances the progression of atherosclerotic lesions and vascular calcification in transgenic rabbits.
Journal of cellular and molecular medicine 04, 2020 | Pubmed ID: 32126159
A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases.
Frontiers in pharmacology , 2020 | Pubmed ID: 32184728
Molecular pharmacokinetic mechanism of the drug-drug interaction between genistein and repaglinide mediated by P-gp.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie May, 2020 | Pubmed ID: 32187961
Organic anion transporters also mediate the drug-drug interaction between imipenem and cilastatin.
Asian journal of pharmaceutical sciences Mar, 2020 | Pubmed ID: 32373203
Targeting renal OATs to develop renal protective agent from traditional Chinese medicines: Protective effect of Apigenin against Imipenem-induced nephrotoxicity.
Phytotherapy research : PTR Nov, 2020 | Pubmed ID: 32468621
CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.
Frontiers in pharmacology , 2020 | Pubmed ID: 32792941
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Phytotherapy research : PTR Feb, 2021 | Pubmed ID: 32914480
Yangonin inhibits ethanol-induced hepatocyte senescence via miR-194/FXR axis.
European journal of pharmacology Jan, 2021 | Pubmed ID: 33068587
Author Correction: Potent effects of dioscin against obesity in mice.
Scientific reports Oct, 2020 | Pubmed ID: 33093537
Puerarin sensitized K562/ADR cells by inhibiting NF-κB pathway and inducing autophagy.
Phytotherapy research : PTR Mar, 2021 | Pubmed ID: 33141989
Phosphocreatine Promotes Osteoblastic Activities in HO-Induced MC3T3-E1 Cells by Regulating SIRT1/FOXO1/PGC-1α Signaling Pathway.
Current pharmaceutical biotechnology , 2021 | Pubmed ID: 33198615
Synthesis and biological activity of imidazole group-substituted arylaminopyrimidines (IAAPs) as potent BTK inhibitors against B-cell lymphoma and AML.
Bioorganic chemistry 01, 2021 | Pubmed ID: 33272709
Identifying the Dominant Contribution of Human Cytochrome P450 2J2 to the Metabolism of Rivaroxaban, an Oral Anticoagulant.
Cardiovascular drugs and therapy Feb, 2022 | Pubmed ID: 33411110
Catalpol-Induced AMPK Activation Alleviates Cisplatin-Induced Nephrotoxicity through the Mitochondrial-Dependent Pathway without Compromising Its Anticancer Properties.
Oxidative medicine and cellular longevity , 2021 | Pubmed ID: 33510841
Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole against Human Carboxylesterase 2.
Current drug metabolism , 2021 | Pubmed ID: 33568030
Luteolin ameliorates LPS-induced acute liver injury by inhibiting TXNIP-NLRP3 inflammasome in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology Jul, 2021 | Pubmed ID: 34044253
Synthesis and biological evaluation of selenogefitinib for reducing bleomycin-induced pulmonary fibrosis.
Bioorganic & medicinal chemistry letters 09, 2021 | Pubmed ID: 34216747
Noncovalent EGFR T790M/L858R inhibitors based on diphenylpyrimidine scaffold: Design, synthesis, and bioactivity evaluation for the treatment of NSCLC.
European journal of medicinal chemistry Nov, 2021 | Pubmed ID: 34218082
Yangonin modulates lipid homeostasis, ameliorates cholestasis and cellular senescence in alcoholic liver disease via activating nuclear receptor FXR.
Phytomedicine : international journal of phytotherapy and phytopharmacology Sep, 2021 | Pubmed ID: 34304130
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Pharmaceutical biology Dec, 2021 | Pubmed ID: 34403325
In vitro Measurement and In vivo Prediction of Time-Dependent Inhibitory Effects of Three Tyrosine Kinase Inhibitors on CYP3A Activity.
Current drug metabolism , 2021 | Pubmed ID: 34473615
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
International immunopharmacology Nov, 2021 | Pubmed ID: 34555641
Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury.
Phytomedicine : international journal of phytotherapy and phytopharmacology Feb, 2022 | Pubmed ID: 34785106
Activation of PGC-1α via isoliquiritigenin-induced downregulation of miR-138-5p alleviates nonalcoholic fatty liver disease.
Phytotherapy research : PTR Jan, 2022 | Pubmed ID: 35041255
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