Robert Langer

The evolution of biomaterials. Interview by Alison Stoddart and Victoria Cleave.

Nanoparticle delivery of suicide DNA for epithelial ovarian cancer therapy.

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery.

Nanotechnology and aptamers: applications in drug delivery.

Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes.

Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy.

Microflow and crack formation patterns in drying sessile droplets of liposomes suspended in trehalose solutions.

nan'o.tech.nol'o.gy n.

Nanocarriers as an emerging platform for cancer therapy.

Microfluidic platform for controlled synthesis of polymeric nanoparticles.

The biocompatibility of mesoporous silicates.

New opportunities: the use of nanotechnologies to manipulate and track stem cells.

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.

Nanoparticles for gene transfer to human embryonic stem cell colonies.

Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation.

A review of Judah Folkman's remarkable achievements in biomedicine.

Assessing siRNA pharmacodynamics in a luciferase-expressing mouse.

FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women.

Association between different measures of blood pressure and coronary artery calcium in postmenopausal women.

Biodegradable poly(polyol sebacate) polymers.

Cell-compatible, multicomponent protein arrays with subcellular feature resolution.

Nanofabricated collagen-inspired synthetic elastomers for primary rat hepatocyte culture.

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles.

Accordion-like honeycombs for tissue engineering of cardiac anisotropy.

Three-dimensional conductive constructs for nerve regeneration.

Transdermal drug delivery.

Developing a distributed research network to conduct population-based studies and safety surveillance.

Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells.

Outbreak of adverse reactions associated with contaminated heparin.

Poly(beta-amino esters): procedures for synthesis and gene delivery.

In vitro and in vivo degradation of poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) elastomers.

PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery.

A drug-eluting contact lens.

Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups.

Knocking down barriers: advances in siRNA delivery.

Incident invasive breast cancer, geographic location of residence, and reported average time spent outside.

Selective removal of photoreceptor cells in vivo using the biodegradable elastomer poly(glycerol sebacate).

Multifunctional nanoparticles for prostate cancer therapy.

Protein nanoparticles engineered to sense kinase activity in MRI.

Impact of nanotechnology on drug delivery.

Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform.

Re: Estrogen plus progestin therapy and breast cancer in recently postmenopausal women.

Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis.

Rheological blends for drug delivery. I. Characterization in vitro.

Development of lipidoid-siRNA formulations for systemic delivery to the liver.

Biocompatibility of biodegradable semiconducting melanin films for nerve tissue engineering.

A novel mechanism is involved in cationic lipid-mediated functional siRNA delivery.

Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery.

A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery.

Engineering retinal progenitor cell and scrollable poly(glycerol-sebacate) composites for expansion and subretinal transplantation.

Prolonged duration local anesthesia with minimal toxicity.

A conversation with Robert Langer: pioneering biomedical scientist and engineer. Interview by Paul S. Weiss.

Blockade of peroxynitrite-induced neural stem cell death in the acutely injured spinal cord by drug-releasing polymer.

Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery.

Progress in tissue engineering.

Implantable diagnostic device for cancer monitoring.

Arpad Gerster and Max Thorek contributions to American surgery.

Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause.

Formulation/preparation of functionalized nanoparticles for in vivo targeted drug delivery.

Engineering substrate topography at the micro- and nanoscale to control cell function.

Cell-responsive hydrogel for encapsulation of vascular cells.

Dehydroepiandrosterone pretreatment alters the ischaemia/reperfusion-induced VEGF, IL-1 and IL-6 gene expression in acute renal failure.

Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs.

High-throughput membrane surface modification to control NOM fouling.

Drug delivery-mediated control of RNA immunostimulation.

High throughput optimization of stem cell microenvironments.

Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice.

Three-dimensional hydrogel model using adipose-derived stem cells for vocal fold augmentation.

Efficacy, safety, and tolerability of low-dose hormone therapy in managing menopausal symptoms.

A magnetically triggered composite membrane for on-demand drug delivery.

Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules.

Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles.

Orthogonal analytical approaches to detect potential contaminants in heparin.

Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma.

High throughput methods applied in biomaterial development and discovery.

Tissue-specific gene delivery via nanoparticle coating.

Photo-targeted nanoparticles.

Vascular differentiation of human embryonic stem cells in bioactive hydrogel-based scaffolds.

Injectable in situ cross-linking hydrogels for local antifungal therapy.

The use of surface modified poly(glycerol-co-sebacic acid) in retinal transplantation.

Relationships among dietary nutrients and subjective sleep, objective sleep, and napping in women.

The Cardiovascular Research Network: a new paradigm for cardiovascular quality and outcomes research.

Aspirin use, dose, and clinical outcomes in postmenopausal women with stable cardiovascular disease: the Women's Health Initiative Observational Study.

Bioinspired materials for controlling stem cell fate.

Lipid-like materials for low-dose, in vivo gene silencing.

Nanoparticulate cellular patches for cell-mediated tumoritropic delivery.

Spatiotemporal controlled delivery of nanoparticles to injured vasculature.

Self-assembled gold nanoparticle molecular probes for detecting proteolytic activity in vivo.

Emerging nanotechnology approaches for HIV/AIDS treatment and prevention.

Impaired metabolism in donor kidney grafts after steroid pretreatment.

Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold.

Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing.

Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine.

Nanoparticle technologies for cancer therapy.

Polymeric nanoparticles for drug delivery.

Establishing a model spinal cord injury in the African green monkey for the preclinical evaluation of biodegradable polymer scaffolds seeded with human neural stem cells.

Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with full-thickness and split-thickness pig and human skin.

A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery.

Optimizing the delivery of cancer drugs that block angiogenesis.

Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models.

Progress in siRNA delivery using multifunctional nanoparticles.

ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation.

Estrogen alone in postmenopausal women and breast cancer detection by means of mammography and breast biopsy.

Transplantation behind the Iron Curtain--a short historical note on the 20th anniversary.

Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells.

Biodegradable xylitol-based elastomers: in vivo behavior and biocompatibility.

Calcium/vitamin D supplementation and coronary artery calcification in the Women's Health Initiative.

Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D.

Does borderline kidney allograft rejection always require treatment?

Vasomotor symptoms and coronary artery calcium in postmenopausal women.

Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions.

Retinal transplantation using surface modified poly(glycerol-co-sebacic acid) membranes.

Stimuli-responsive microwells for formation and retrieval of cell aggregates.

Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds.

Poly(ethylene glycol) with observable shedding.

Transplantation in Hungary--preface on the occasion of Transplantation Proceedings becoming the official journal of the Hungarian Transplantation Society.

Steroid pretreatment of organ donors to prevent postischemic renal allograft failure: a randomized, controlled trial.

Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery.

Combined technologies for microfabricating elastomeric cardiac tissue engineering scaffolds.

Nanotechnology in drug delivery and tissue engineering: from discovery to applications.

Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells.

Transport pathways and enhancement mechanisms within localized and non-localized transport regions in skin treated with low-frequency sonophoresis and sodium lauryl sulfate.

CanScript, an 18-Base pair DNA sequence, boosts tumor cell-specific promoter activity: implications for targeted gene therapy.

Molecular biomarker candidates of acute kidney injury in zero-hour renal transplant needle biopsies.

A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells.

Polymer surface functionalities that control human embryoid body cell adhesion revealed by high throughput surface characterization of combinatorial material microarrays.

Mortality related to actigraphic long and short sleep.

An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate.

Perspectives and challenges in tissue engineering and regenerative medicine.

Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy.

High throughput surface characterization: A review of a new tool for screening prospective biomedical material arrays.

Mesenchymal stem cell mechanics from the attached to the suspended state.

Application of the aqueous porous pathway model to quantify the effect of sodium lauryl sulfate on ultrasound-induced skin structural perturbation.

Enhancing the transdermal delivery of rigid nanoparticles using the simultaneous application of ultrasound and sodium lauryl sulfate.

Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction.

Evaluation of viscoelastic poly(ethylene glycol) sols as vitreous substitutes in an experimental vitrectomy model in rabbits.

Low-frequency sonophoresis: application to the transdermal delivery of macromolecules and hydrophilic drugs.

On firm ground: IP protection of therapeutic nanoparticles.

Real-time in vivo detection of biomaterial-induced reactive oxygen species.

Nanotechnological strategies for engineering complex tissues.

Efficient Hydrogenation of Ketones Catalyzed by an Iron Pincer Complex.

Intracranial microcapsule drug delivery device for the treatment of an experimental gliosarcoma model.

Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers.

Experimental and molecular dynamics investigation into the amphiphilic nature of sulforhodamine B.

Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends.

[Evaluation of patients' readiness for surgery when called from the waiting list for kidney transplantation: experience of the Budapest Centre].

A "Self-Pinning" Adhesive Based on Responsive Surface Wrinkles.

[Eurotransplant--new possibility for the Hungarian transplantation].

Application of a dense gas technique for sterilizing soft biomaterials.

Efficient hydrogenation of ketones catalyzed by an iron pincer complex.

Magnetically triggered nanocomposite membranes: a versatile platform for triggered drug release.

Indirect low-intensity ultrasonic stimulation for tissue engineering.

Current trends in nanobiosensor technology.

A novel family of biodegradable poly(ester amide) elastomers.

Spatiotemporal effects of a controlled-release anti-inflammatory drug on the cellular dynamics of host response.

Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels.

Responsive microgrooves for the formation of harvestable tissue constructs.

Chondrogenic priming adipose-mesenchymal stem cells for cartilage tissue regeneration.

Assessment of canine vocal fold function after injection of a new biomaterial designed to treat phonatory mucosal scarring.

Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives.

Renoprotective effect of erythropoietin in rats subjected to ischemia/reperfusion injury: gender differences.

Facile synthetic route for surface-functionalized magnetic nanoparticles: cell labeling and magnetic resonance imaging studies.

New chances for Hungarian transplantation--preface to the 12th Congress of the Hungarian Transplantation Society.

Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles.

Five years of siRNA delivery: spotlight on gold nanoparticles.

Poly(β-amino ester)-DNA complexes: time-resolved fluorescence and cellular transfection studies.

Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery.

Intracellular trafficking of polyamidoamine-poly(ethylene glycol) block copolymers in DNA delivery.

Serum selenium, genetic variation in selenoenzymes, and risk of colorectal cancer: primary analysis from the Women's Health Initiative Observational Study and meta-analysis.

Responsive micromolds for sequential patterning of hydrogel microstructures.

Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery.

Research agenda. Promoting convergence in biomedical science.

Microgels for efficient protein purification.

Directing human embryonic stem cell differentiation by non-viral delivery of siRNA in 3D culture.

Hydroxyapatite for keratoprosthesis biointegration.

Liposomes for HIV prophylaxis.

Three-dimensional biomaterials for the study of human pluripotent stem cells.

Materials science: Dry solution to a sticky problem.

Nanoparticle delivery of cancer drugs.

Nanoparticles targeting the infarcted heart.

Role of organ transplantation in the treatment of malignancies: hepatocellular carcinoma as the most common tumour treated with transplantation.

Low-Pressure Hydrogenation of Carbon Dioxide Catalyzed by an Iron Pincer Complex Exhibiting Noble Metal Activity.

Nanowired three-dimensional cardiac patches.

The influence of scaffold elasticity on germ layer specification of human embryonic stem cells.

Therapeutic siRNA silencing in inflammatory monocytes in mice.

Reshaping the future of nanopharmaceuticals: ad iudicium.

[Incidence of thrombophilia and risk of renal vessel thrombosis in kidney transplant recipients].

Fluorescent penetration enhancers for transdermal applications.

Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions.

In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles.

A physical mechanism to explain the delivery of chemical penetration enhancers into skin during transdermal sonophoresis - Insight into the observed synergism.

Roma ethnicity and clinical outcomes in kidney transplant recipients.

Combinatorial library of lipidoids for in vitro DNA delivery.

Forty-year journey of angiogenesis translational research.

Treating metastatic cancer with nanotechnology.

Recent developments in multifunctional hybrid nanoparticles: opportunities and challenges in cancer therapy.

Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection.

Progress in the Tissue Engineering and Stem Cell Industry "Are we there yet?"

Superstructure based on β-CD self-assembly induced by a small guest molecule.

The Effect of Steroid Pretreatment of Deceased Organ Donors on Liver Allograft Function: A Blinded Randomized Placebo Controlled Trial.

Toxicogenomic analysis of a sustained release local anesthetic delivery system.

Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity.

First-in-human testing of a wirelessly controlled drug delivery microchip.

Hypnotics' association with mortality or cancer: a matched cohort study.

Photoswitchable nanoparticles for triggered tissue penetration and drug delivery.

Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery.

Remotely activated protein-producing nanoparticles.

Therapeutic angiogenesis using genetically engineered human endothelial cells.

Reservoir-based drug delivery systems utilizing microtechnology.

Everolimus plus early tacrolimus minimization: a phase III, randomized, open-label, multicentre trial in renal transplantation.

Surface charge-switching polymeric nanoparticles for bacterial cell wall-targeted delivery of antibiotics.

Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer.

Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile.

Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics.

Iron borohydride pincer complexes for the efficient hydrogenation of ketones under mild, base-free conditions: synthesis and mechanistic insight.

Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging.

Melanin-like hydrogels derived from gallic macromers.

YY1 regulates melanocyte development and function by cooperating with MITF.

Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model.

Functional multipotency of stem cells: a conceptual review of neurotrophic factor-based evidence and its role in translational research.

FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA nanocomplexes.

Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network.

Laparoscopic donor nephrectomy techniques.

Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices.

A 3D interconnected microchannel network formed in gelatin by sacrificial shellac microfibers.

The smartest materials: the future of nanoelectronics in medicine.

Combinatorial discovery of polymers resistant to bacterial attachment.

[Recent options in drug therapy after solid organ transplantation].

Do no harm: not even to some degree.

Localized delivery of dexamethasone from electrospun fibers reduces the foreign body response.

Macroporous nanowire nanoelectronic scaffolds for synthetic tissues.

Nanocomposite gold-silk nanofibers.

Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound.

Detection and management of renal cell carcinoma in the renal allograft.

Controlling spatial organization of multiple cell types in defined 3D geometries.

Crosslinked linear polyethylenimine enhances delivery of DNA to the cytoplasm.

Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles.

Vascular catheters with a nonleaching poly-sulfobetaine surface modification reduce thrombus formation and microbial attachment.

Microfluidic technologies for accelerating the clinical translation of nanoparticles.

Prolonged nerve blockade delays the onset of neuropathic pain.

Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles.

Thermoresponsive Platforms for Tissue Engineering and Regenerative Medicine.

Quick-release medical tape.

Nonendocytic delivery of functional engineered nanoparticles into the cytoplasm of live cells using a novel, high-throughput microfluidic device.

Formulations for trans-tympanic antibiotic delivery.

Leading the way in biomedical engineering: an interview with Robert Langer. Interview by Hannah Stanwix, Commissioning Editor.

Materials for diabetes therapeutics.

Three-dimensional elastomeric scaffolds designed with cardiac-mimetic structural and mechanical features.

Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility.

Microstructured barbs on the North American porcupine quill enable easy tissue penetration and difficult removal.

Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.

A highly tunable biocompatible and multifunctional biodegradable elastomer.

Modular 'click-in-emulsion' bone-targeted nanogels.

Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability.

Bio-inspired polymer composite actuator and generator driven by water gradients.

A vector-free microfluidic platform for intracellular delivery.

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.

Stepwise metal-ligand cooperation by a reversible aromatization/deconjugation sequence in ruthenium complexes with a tetradentate phenanthroline-based ligand.

Lipidoid-coated iron oxide nanoparticles for efficient DNA and siRNA delivery.

Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays.

BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition.

Strategies for MCR image analysis of large hyperspectral data-sets.

High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry.

Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers.

Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles.

One-Step Multipurpose Surface Functionalization by Adhesive Catecholamine.

Injectable nano-network for glucose-mediated insulin delivery.

Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug.

Live well: a practical and effective low-intensity dietary counseling intervention for use in primary care patients with dyslipidemia--a randomized controlled pilot trial.

A Stiff Injectable Biodegradable Elastomer.

Nanoparticle encapsulation of mitaplatin and the effect thereof on in vivo properties.

Combinatorial synthesis with high throughput discovery of protein-resistant membrane surfaces.

[Milestone in Hungarian organ transplantation: joining Eurotransplant].

[50-year history of kidney transplantation in Hungary].

[Role of simultaneous pancreas-kidney transplantation in the treatment of diabetes mellitus].

Biomaterials and biotechnology: from the discovery of the first angiogenesis inhibitors to the development of controlled drug delivery systems and the foundation of tissue engineering.

A personal account of translating discoveries in an academic lab.

3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture.

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling.

Formation of an iron phosphine-borane complex by formal insertion of BH₃ into the Fe-P bond.

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform.

Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery.

Enhanced photothermal effect of plasmonic nanoparticles coated with reduced graphene oxide.

Synthesis, structures, and dearomatization by deprotonation of iron complexes featuring bipyridine-based PNN pincer ligands.

Drug delivery interfaces in the 21st century: from science fiction ideas to viable technologies.

Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy.

Neighborhood Environment and Physical Activity Among Older Women: Findings From the San Diego Cohort of the Women's Health Initiative.

Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study.

Correction to Mass Production and Size Control of Lipid-Polymer Hybrid Nanoparticles through Controlled Microvortices.

Rational design of a biomimetic cell penetrating Peptide library.

A photo-triggered layered surface coating producing reactive oxygen species.

Single Step Reconstitution of Multifunctional High-Density Lipoprotein-Derived Nanomaterials Using Microfluidics.

Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces.

Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation.

Electrical stimulation via a biocompatible conductive polymer directs retinal progenitor cell differentiation.

Translating materials design to the clinic.

Stretchable Polymeric Multielectrode Array for Conformal Neural Interfacing.

Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug.

High-throughput methods for screening polymeric transfection reagents.