Takanari Inoue

Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding.

Spatiotemporal laser inactivation of inositol 1,4,5-trisphosphate receptors using synthetic small-molecule probes.

Modification of intracellular Ca2+ dynamics by laser inactivation of inositol 1,4,5-trisphosphate receptor using membrane-permeant probes.

An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways.

Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels.

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.

Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.

An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells.

Robust neuronal symmetry breaking by Ras-triggered local positive feedback.

Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer.

Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor.

Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration.

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

Organelle-specific, rapid induction of molecular activities and membrane tethering.

A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity.

Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method.

Triggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganization.