Darlene A. Dartt

Role of protein kinase C in cholinergic stimulation of lacrimal gland protein secretion.

Alpha 1-adrenergic and cholinergic agonists activate MAPK by separate mechanisms to inhibit secretion in lacrimal gland.

Regulation of mucin and fluid secretion by conjunctival epithelial cells.

VEGF-dependent conjunctivalization of the corneal surface.

Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland.

Role of Ca2+ and protein kinase C in cholinergic, and alpha1-adrenergic agonists and EGF stimulated mitogen-activated protein kinase activity in lacrimal gland.

Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion.

Role of mitogen-activated protein kinase in cholinergic stimulation of conjunctival goblet cell secretion.

Isolation and characterization of human goblet cells in vitro: regulation of proliferation and activation of mitogen-activated protein kinase by EGF and carbachol.

Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion.

Isolation and characterization of cultured human conjunctival goblet cells.

Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells.

Presence and localization of neurotrophins and neurotrophin receptors in rat lacrimal gland.

Regulatory pathways in lacrimal gland epithelium.

Control of mucin production by ocular surface epithelial cells.

Interaction of EGF family growth factors and neurotransmitters in regulating lacrimal gland secretion.

Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion.

Bcl-2 enhances Ca(2+) signaling to support the intrinsic regenerative capacity of CNS axons.

Age-dependent alterations in mouse exorbital lacrimal gland structure, innervation and secretory response.

Nitric oxide and cGMP mediate alpha1D-adrenergic receptor-Stimulated protein secretion and p42/p44 MAPK activation in rat lacrimal gland.

Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells.

OPC-12759 increases proliferation of cultured rat conjunctival goblet cells.

Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK.

Lymphocytic infiltration and goblet cell marker alteration in the conjunctiva of the MRL/MpJ-Fas(lpr) mouse model of Sjögren's syndrome.

Dysfunctional neural regulation of lacrimal gland secretion and its role in the pathogenesis of dry eye syndromes.

Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation.

Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland.

Effect of protein kinase C and Ca(2+) on p42/p44 MAPK, Pyk2, and Src activation in rat conjunctival goblet cells.

Presence of EGF growth factor ligands and their effects on cultured rat conjunctival goblet cell proliferation.

Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells.

ERK/p44p42 mitogen-activated protein kinase mediates EGF-stimulated proliferation of conjunctival goblet cells in culture.

Role of cPKCalpha and nPKCepsilon in EGF-stimulated goblet cell proliferation.

The aging lacrimal gland: changes in structure and function.

Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation.

Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases.

Characterization of P2X7 purinergic receptors and their function in rat lacrimal gland.

Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice.

Identification of the Raf-1 signaling pathway used by cAMP to inhibit p42/p44 MAPK in rat lacrimal gland acini: role in potentiation of protein secretion.

Phospholipase D1, but not D2, regulates protein secretion via Rho/ROCK in a Ras/Raf-independent, MEK-dependent manner in rat lacrimal gland.

Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation.

Identification of P2X₃ and P2X₇ purinergic receptors activated by ATP in rat lacrimal gland.

Cholinergic agonists activate P2X7 receptors to stimulate protein secretion by the rat lacrimal gland.

Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion.

Tear lipocalin: structure and function.

Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells.

Isolation and characterization of progenitor cells in uninjured, adult rat lacrimal gland.

Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion.

Effect of biopsy location and size on proliferative capacity of ex vivo expanded conjunctival tissue.

Effect of histamine on Ca(2+)-dependent signaling pathways in rat conjunctival goblet cells.

Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion.

New twists to an old story: novel concepts in the pathogenesis of allergic eye disease.

Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion.

Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells.

miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.

Role of PKCα activation of Src, PI-3K/AKT, and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells.

Tear film mucins: front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins.

Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells.

Complexity of the tear film: importance in homeostasis and dysfunction during disease.

Polymorphism in THBS1 gene is associated with post-refractive surgery chronic ocular surface inflammation.

The impact of storage temperature on the morphology, viability, cell number and metabolism of cultured human conjunctival epithelium.

Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation.

Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.

Serum-free and xenobiotic-free preservation of cultured human limbal epithelial cells.

Effect of Storage Temperature on Structure and Function of Cultured Human Oral Keratinocytes.

Conjunctival Goblet Cell Function: Effect of Contact Lens Wear and Cytokines.

Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis, Homeostasis, and Repair.

Concise Review: Comparison of Culture Membranes Used for Tissue Engineered Conjunctival Epithelial Equivalents.

Chronic dry eye in photorefractive keratectomy and laser in situ keratomileusis: Manifestations, incidence, and predictive factors.

Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes.

Lipoxin A activates ALX/FPR2 receptor to regulate conjunctival goblet cell secretion.

Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility.

Signaling Pathways of Purinergic Receptors and Their Interactions with Cholinergic and Adrenergic Pathways in the Lacrimal Gland.

Alteration in cellular turnover and progenitor cell population in lacrimal glands from thrombospondin 1 mice, a model of dry eye.

Lipoxin A Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells.

Artificial Polymeric Scaffolds as Extracellular Matrix Substitutes for Autologous Conjunctival Goblet Cell Expansion.

Identification of Objective Morphometric Markers of Xerostomia in the Oral Mucosa Epithelium with In Vivo Confocal Microscopy.

Lacrimal Gland Repair Using Progenitor Cells.

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics.

Tissue Harvesting Site and Culture Medium Affect Attachment, Growth, and Phenotype of Ex Vivo Expanded Oral Mucosal Epithelial Cells.

TFOS DEWS II pain and sensation report.

Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets.

Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways.

Neither non-toxigenic nor commensal activates NLRP3 inflammasomes in human conjunctival goblet cells.

Alteration in nerves and neurotransmitter stimulation of lacrimal gland secretion in the TSP-1 mouse model of aqueous deficiency dry eye.

Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia.

Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca in cultured rat conjunctival goblet cells.

The Level of Inflammatory Tear Cytokines is Elevated in Congenital Aniridia and Associated with Meibomian Gland Dysfunction.

Activation of the EGF Receptor by Histamine Receptor Subtypes Stimulates Mucin Secretion in Conjunctival Goblet Cells.

Context-Dependent Regulation of Conjunctival Goblet Cell Function by Allergic Mediators.

Tear Production Levels and Dry Eye Disease Severity in a Large Norwegian Cohort.

Molecular layer deposition builds biocompatible substrates for epithelial cells.

Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model.

Thrombospondin-1 Is Necessary for the Development and Repair of Corneal Nerves.

Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells.

Meibomian Gland Morphology Is a Sensitive Early Indicator of Meibomian Gland Dysfunction.

Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment.

Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients.

Resolvin D2 elevates cAMP to increase intracellular [Ca] and stimulate secretion from conjunctival goblet cells.

Functional and Morphological Evaluation of Meibomian Glands in the Assessment of Meibomian Gland Dysfunction Subtype and Severity.

Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface.

Diagnostic Test Efficacy of Meibomian Gland Morphology and Function.

Simple limbal epithelial transplantation: Current status and future perspectives.

Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease.

RvE1 uses the LTB receptor BLT1 to increase [Ca] and stimulate mucin secretion in cultured rat and human conjunctival goblet cells.

Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca ] and secretion in conjunctival goblet cells.

Resolvin E1 Reduces Leukotriene B4-Induced Intracellular Calcium Increase and Mucin Secretion in Rat Conjunctival Goblet Cells.

Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease.

Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture.

Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients.

Mouse Models of Sjögren's Syndrome with Ocular Surface Disease.

Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases.

The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration.

Biological tissues and components, and synthetic substrates for conjunctival cell transplantation.

Benzalkonium Chloride-Preserved Anti-Glaucomatous Eye Drops and Their Effect on Human Conjunctival Goblet Cells in vitro.

Characterisation of Gel-Forming Mucins Produced In Vivo and In Ex Vivo Conjunctival Explant Cultures.

The association between visual display terminal use and dry eye: a review.

Chambered warm moist air eyelid warming devices - a review.

TheraPearl Eye Mask and Blephasteam for the treatment of meibomian gland dysfunction: a randomized, comparative clinical trial.

Role of the Phospholipase C Pathway and Calcium Mobilization in Oxytocin-Induced Contraction of Lacrimal Gland Myoepithelial Cells.

Impact of benzalkonium chloride-preserved and preservative-free latanoprost eye drops on cultured human conjunctival goblet cells upon acute exposure and differences in physicochemical properties of the eye drops.

Resolvin D2 and Resolvin D1 Differentially Activate Protein Kinases to Counter-Regulate Histamine-Induced [Ca] Increase and Mucin Secretion in Conjunctival Goblet Cells.

In-office thermal systems for the treatment of dry eye disease.

Review on the possible pathophysiological mechanisms underlying visual display terminal-associated dry eye disease.

Hyaluronic acid in the treatment of dry eye disease.

Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1.

Resolvin D2 uses multiple Ca -dependent signaling pathways to stimulate mucin secretion in rat and human conjunctival goblet cells.

Sex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators.

Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis - A review.

Spatial transcriptomics of the lacrimal gland features macrophage activity and epithelium metabolism as key alterations during chronic inflammation.

Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface.

Hot towels: The bedrock of Meibomian gland dysfunction treatment - A review.

Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism.

The First Transcriptomic Atlas of the Adult Lacrimal Gland Reveals Epithelial Complexity and Identifies Novel Progenitor Cells in Mice.

Anti-Inflammatory and Pro-resolving Actions of the N-Terminal Peptides Ac2-26, Ac2-12, and Ac9-25 of Annexin A1 on Conjunctival Goblet Cell Function.