Shaf Keshavjee

A novel minimally invasive near-infrared thoracoscopic localization technique of small pulmonary nodules: A phase I feasibility trial.

Stability and heterogeneity of expression profiles in lung cancer specimens harvested following surgical resection.

Organ donor management in Canada: recommendations of the forum on Medical Management to Optimize Donor Organ Potential.

The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival.

Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome.

Functions of type II pneumocyte-derived vascular endothelial growth factor in alveolar structure, acute inflammation, and vascular permeability.

XB130, a novel adaptor protein, promotes thyroid tumor growth.

Regression of allograft airway fibrosis: the role of MMP-dependent tissue remodeling in obliterative bronchiolitis after lung transplantation.

Induction of immunological tolerance towards adenoviral vectors using a novel dendritic cell-based strategy.

Pulmonary bacterial communities in surgically resected noncystic fibrosis bronchiectasis lungs are similar to those in cystic fibrosis.

Claudin 1 mediates TNFα-induced gene expression and cell migration in human lung carcinoma cells.

Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice.

A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator.

XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt.

Analysis of the cystic fibrosis lung microbiota via serial Illumina sequencing of bacterial 16S rRNA hypervariable regions.

XB130, a new adaptor protein, regulates expression of tumor suppressive microRNAs in cancer cells.

A novel minimally invasive technique to create a rabbit VX2 lung tumor model for nano-sized image contrast and interventional studies.

Bone marrow-derived progenitor cells in end-stage lung disease patients.

Elevated CXCL10 (IP-10) in bronchoalveolar lavage fluid is associated with acute cellular rejection after human lung transplantation.

Efficient gene delivery to pig airway epithelia and submucosal glands using helper-dependent adenoviral vectors.

Overview of clinical lung transplantation.

Metabolomic heterogeneity of pulmonary arterial hypertension.

XB130 deficiency affects tracheal epithelial differentiation during airway repair.

De novo synthesize of bile acids in pulmonary arterial hypertension lung.

Thymectomy for non-thymomatous myasthenia gravis: a propensity score matched study.

Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas.

Impact of CLAD Phenotype on Survival After Lung Retransplantation: A Multicenter Study.

Minimally invasive electro-magnetic navigational bronchoscopy-integrated near-infrared-guided sentinel lymph node mapping in the porcine lung.

Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis.

A Biochemical Approach to Understand the Pathogenesis of Advanced Pulmonary Arterial Hypertension: Metabolomic Profiles of Arginine, Sphingosine-1-Phosphate, and Heme of Human Lung.

Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation.

Video-assisted transcervical thymectomy for myasthenia gravis.

Pulmonary vascular changes 22 years after single lung transplantation for pulmonary arterial hypertension: a case report with molecular and pathological analysis.

Clinical role of a new prognostic score using platelet-to-lymphocyte ratio in patients with malignant pleural mesothelioma undergoing extrapleural pneumonectomy.

A window of opportunity study of potential tumor and soluble biomarkers of response to preoperative erlotinib in early stage non-small cell lung cancer.

An Integrated Nanotechnology-Enabled Transbronchial Image-Guided Intervention Strategy for Peripheral Lung Cancer.

SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.

Pulmonary and atrial resection and reconstruction for sarcoma with intracardiac extension.

Sevoflurane Attenuates Ischemia-Reperfusion Injury in a Rat Lung Transplantation Model.

High Risk for Thoracotomy but not Thoracoscopic Lobectomy.

Cost-effectiveness of mediastinal lymph node staging in non-small cell lung cancer.

Impact of tumour thickness on survival after radical radiation and surgery in malignant pleural mesothelioma.

The American Association for Thoracic Surgery/Society of Thoracic Surgeons position statement on developing clinical practice documents.

The American Association for Thoracic Surgery/Society of Thoracic Surgeons Position Statement on Developing Clinical Practice Documents.

Pentraxin 3 levels in bronchoalveolar lavage fluid of lung transplant recipients with invasive aspergillosis.

Chest Wall Resection for Recurrent Breast Cancer in the Modern Era: A Systematic Review and Meta-analysis.

The role of biomechanical anatomical modeling via computed tomography for identification of restrictive allograft syndrome.

Higher M30 and high mobility group box 1 protein levels in ex vivo lung perfusate are associated with primary graft dysfunction after human lung transplantation.

Development of a novel porcine laparoscopic Heller myotomy and Nissen fundoplication training model (Toronto lap-Nissen simulator).

Extracorporeal support in airway surgery.

Metabolic heterogeneity of idiopathic pulmonary fibrosis: a metabolomic study.

Performance of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Isolated Mediastinal and Hilar Lymphadenopathy.

α-Anti-trypsin improves function of porcine donor lungs during ex-vivo lung perfusion.

Utility of transthoracic needle biopsy after lung transplantation.

Metabolic Profile of Ex Vivo Lung Perfusate Yields Biomarkers for Lung Transplant Outcomes.

Extracorporeal life support as a bridge to lung transplantation-experience of a high-volume transplant center.

Lung in a Box: Ex Vivo Lung Transplantation.

Effects of Warm Versus Cold Ischemic Donor Lung Preservation on the Underlying Mechanisms of Injuries During Ischemia and Reperfusion.

Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model.

A strategy for prevention of fungal infections in lung transplantation: Role of bronchoalveolar lavage fluid galactomannan and fungal culture.

Upregulation of alveolar neutrophil enzymes and long pentraxin-3 in human chronic lung allograft dysfunction subtypes.

Efficacy and Cost of Awake Thoracoscopy and Video-Assisted Thoracoscopic Surgery in the Undiagnosed Pleural Effusion.

miR-145 expression enhances integrin expression in SK-GT-4 cell line by down-regulating c-Myc expression.

Quantitative chest CT for subtyping chronic lung allograft dysfunction and its association with survival.

Comprehensive outcomes after lung retransplantation: A single-center review.

Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation.

Inhibition of regulated necrosis attenuates receptor-interacting protein kinase 1-mediated ischemia-reperfusion injury after lung transplantation.

Visualizing Heterogeneous Pulmonary Ventilation. Respiratory Failure due to an Anterior Mediastinal Mass.

A novel combined ex vivo and in vivo lentiviral interleukin-10 gene delivery strategy at the time of transplantation decreases chronic lung allograft rejection in mice.

Introducing the concept of semielective lung transplantation through the use of ex vivo lung perfusion.

Ischemia-reperfusion induces death receptor-independent necroptosis via calpain-STAT3 activation in a lung transplant setting.

Pig lung transplant survival model.

Favourable health-related quality of life reported in survivors of thymic malignancies.

Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation.

Porphyrin-High-Density Lipoprotein: A Novel Photosensitizing Nanoparticle for Lung Cancer Therapy.

Echinocandin use in lung transplant recipients.

Spectrum of chronic lung allograft pathology in a mouse minor-mismatched orthotopic lung transplant model.

Neutrophil extracellular traps in lung perfusion perfusate predict the clinical outcome of lung transplant recipients.

Lentiviral interleukin-10 gene therapy: Safety and questions.

Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion.

CT-guided Microcoil Pulmonary Nodule Localization prior to Video-assisted Thoracoscopic Surgery: Diagnostic Utility and Recurrence-Free Survival.

Cytokine profile in lung transplant recipients with Aspergillus spp colonization.

Molecular assessment of rejection and injury in lung transplant biopsies.

3D Models in the Diagnosis of Subglottic Airway Stenosis.

Donor prone positioning protects lungs from injury during warm ischemia.

Uniportal Video-Assisted Transcervical Thymectomy.

Endobronchial ultrasound-guided transbronchial needle aspiration mediastinal lymph node staging in malignant pleural mesothelioma.

Chronic meningitis in a lung transplant recipient.

Epithelial cell death markers in bronchoalveolar lavage correlate with chronic lung allograft dysfunction subtypes and survival in lung transplant recipients-a single-center retrospective cohort study.

Veno-venous extracorporeal life support for blastomycosis-associated acute respiratory distress syndrome.

A successful lung transplant from a 3-year-old donor after controlled cardiac death followed by ex vivo lung perfusion: A case report.

Donor human leukocyte antigen-G single nucleotide polymorphisms are associated with post-lung transplant mortality.

Lung cancer photothermal ablation by low-power near-infrared laser and topical injection of indocyanine green.

Lung Density Analysis Using Quantitative Chest CT for Early Prediction of Chronic Lung Allograft Dysfunction.

A B cell-dependent pathway drives chronic lung allograft rejection after ischemia-reperfusion injury in mice.

The impact of first untreated subclinical minimal acute rejection on risk for chronic lung allograft dysfunction or death after lung transplantation.

Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation.

Cricotracheal resection for adult subglottic stenosis: Factors predicting treatment failure.

Drug-resistant cytomegalovirus infection after lung transplantation: Incidence, characteristics, and clinical outcomes.

Bilateral Lobar Transplants Using One Donor for Two Small-Sized Recipients.

Long-term Outcomes of Lung Transplant With Ex Vivo Lung Perfusion.

Normothermic ex vivo lung perfusion: Does the indication impact organ utilization and patient outcomes after transplantation?

Prevention of viral transmission during lung transplantation with hepatitis C-viraemic donors: an open-label, single-centre, pilot trial.

Prognostic influence of tumor microenvironment after hypofractionated radiation and surgery for mesothelioma.

Incidence of Ipsilateral Side Recurrence After Open or Video-Assisted Thoracic Surgery Resection of Colorectal Lung Metastases.

Initial lung transplantation experience with uncontrolled donation after cardiac death in North America.

Granuloma in the explanted lungs: Infectious causes and impact on post-lung transplant mycobacterial infection.

Potential therapeutic targets for lung repair during human lung perfusion.

Increased Arginase Expression and Decreased Nitric Oxide in Pig Donor Lungs after Normothermic Ex Vivo Lung Perfusion.

Late Onset Invasive Pulmonary Aspergillosis in Lung Transplant Recipients in the Setting of a Targeted Prophylaxis/Preemptive Antifungal Therapy Strategy.

Lung transplantation for cystic fibrosis.

The Impact of Inadequate ("AX") Transbronchial Biopsies on Post-lung Transplant CLAD or Death.

Extending cytomegalovirus prophylaxis in high-risk (D+/R-) lung transplant recipients from 6 to 9 months reduces cytomegalovirus disease: A retrospective study.

An extracellular oxygen carrier during prolonged pulmonary preservation improves post-transplant lung function.

A model to assess acute and delayed lung toxicity of oxaliplatin during in vivo lung perfusion.

Short-course, direct-acting antivirals and ezetimibe to prevent HCV infection in recipients of organs from HCV-infected donors: a phase 3, single-centre, open-label study.

Risk assessment of chronic lung allograft dysfunction phenotypes: Validation and proposed refinement of the 2019 International Society for Heart and Lung Transplantation classification system.

Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration.

The case for routine screening for SARS-CoV-2 before surgery.

Personalized Ventilation to Multiple Patients Using a Single Ventilator: Description and Proof of Concept.

Deceased-donor lobar lung transplant: A successful strategy for small-sized recipients.

Retrospective study of the incidence and outcomes from lung cancer in solid organ transplant recipients.

Impact of donor time to cardiac arrest in lung donation after circulatory death.

Identifying host microRNAs in bronchoalveolar lavage samples from lung transplant recipients infected with Aspergillus.

International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation.

Lung donation after medical assistance in dying at home.

Surgical Morbidity of Full-Thickness Chest Wall Resection for Breast Cancer: A Retrospective Study of a National Database.

When to consider lung transplantation for COVID-19.

Cell-free DNA in human ex vivo lung perfusate as a potential biomarker to predict the risk of primary graft dysfunction in lung transplantation.

The impact of concordance with a lung cancer diagnosis pathway guideline on treatment access in patients with stage IV lung cancer.

Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation.

Strategies to prolong homeostasis of ex vivo perfused lungs.

Ex vivo lung perfusion for donor lung assessment and repair: a review of translational interspecies models.

Eosinophils in transbronchial biopsies: a predictor of chronic lung allograft dysfunction and reduced survival after lung transplantation - a retrospective single-center cohort study.

Effect of Driving Pressure Change During Extracorporeal Membrane Oxygenation in Adults With Acute Respiratory Distress Syndrome: A Randomized Crossover Physiologic Study.

Rare indications for a lung transplant. A European Society of Thoracic Surgeons survey.

Veno-venous ECMO as a platform to evaluate lung lavage and surfactant replacement therapy in an animal model of severe ARDS.

Transcriptomic investigation reveals donor-specific gene signatures in human lung transplants.

Ventilation parameters and early graft function in double lung transplantation.

Donor ventilation parameters as predictors for length of mechanical ventilation after lung transplantation: Results of a prospective multicenter study.

Alpha-1 Antitrypsin for COVID-19 Treatment: Dual Role in Antiviral Infection and Anti-Inflammation.

CYP51A polymorphisms of Aspergillus fumigatus in lung transplant recipients: Prevalence, correlation with phenotype, and impact on outcomes.

Surgery for malignant pleural mesothelioma after radiotherapy (SMART): final results from a single-centre, phase 2 trial.

Safety of continuous 12-hour delivery of antimicrobial doses of inhaled nitric oxide during ex vivo lung perfusion.

Successful lung transplantation from lungs procured 12 hours after withdrawal of life-sustaining therapy: Changing the paradigm of controlled DCD donors?

Thymoma pathology and myasthenia gravis outcomes.

Using nutrient-rich solutions and adding multiple cytoprotective agents as new strategies to develop lung preservation solutions.

Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion.

A call to routinely test lower respiratory tract samples for SARS-CoV-2 in lung donors.

Prediction of donor related lung injury in clinical lung transplantation using a validated ex vivo lung perfusion inflammation score.

Prognostic Significance of Pulmonary Multifocal Neuroendocrine Proliferation With Typical Carcinoid.

Use of metabolomics to identify strategies to improve and prolong ex vivo lung perfusion for lung transplants.

Predicting donor lung acceptance for transplant during ex vivo lung perfusion: The EX vivo lung PerfusIon pREdiction (EXPIRE).

Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context.

Pushing the Envelope for Donor Lungs.

Telerehabilitation for Lung Transplant Candidates and Recipients During the COVID-19 Pandemic: Program Evaluation.

Long-term outcomes of sensitized lung transplant recipients after peri-operative desensitization.

Achieving Safe Liberation During Weaning From VV-ECMO in Patients With Severe ARDS: The Role of Tidal Volume and Inspiratory Effort.

Diffusing capacity of the lung for carbon monoxide: association with long-term outcomes after lung transplantation in a 20-year longitudinal study.

The accuracy of forced vital capacity for diagnosing restrictive allograft syndrome and mixed phenotype of chronic lung allograft dysfunction.

Bronchoalveolar lavage cytokine-based risk stratification of minimal acute rejection in clinically stable lung transplant recipients.

Surfactant therapy in lung transplantation: A systematic review and meta-analysis.

A simplified strategy for donor-recipient size-matching in lung transplant for interstitial lung disease.

Maintaining technical proficiency in senior surgical fellows during the COVID-19 pandemic through virtual teaching.

Tracheobronchoplasty followed by bilateral lung transplantation for Mounier-Kuhn syndrome.

delivery of regulatory T-cells for control of alloimmune priming in the donor lung.

Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function.

Recipient bone marrow-derived IL-17 receptor A-positive cells drive allograft fibrosis in a mouse intrapulmonary tracheal transplantation model.

A novel pre-clinical strategy to deliver antimicrobial doses of inhaled nitric oxide.

Engineered mesenchymal stromal cell therapy during human lung lung perfusion is compromised by acidic lung microenvironment.

Significance of phenotype change after chronic lung allograft dysfunction onset.

Connective-Tissue Growth Factor Contributes to TGF-β1-induced Lung Fibrosis.

Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin.

Transcripts associated with chronic lung allograft dysfunction in transbronchial biopsies of lung transplants.

Postoperative Management of Lung Transplant Recipients in the Intensive Care Unit.

lung perfusion.

Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles.

Outcomes of lung transplantation from organ donation after medical assistance in dying: First North American experience.

Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs.

Expression of cystic fibrosis lung disease modifier genes in human airway models.

Importance of tumor size in resectable stage III-N2 non-small cell lung cancer.

Lung transplantation for acute respiratory distress syndrome.

Near-infrared fluorescence imaging during ex vivo lung perfusion: Noninvasive real-time evaluation of regional lung perfusion and edema.

Statement regarding events in Ukraine from Shaf Keshavjee, MD, 102nd President, The American Association for Thoracic Surgery.

Survival After Lung Transplantation for Chronic Hypersensitivity Pneumonitis: Results From a Large International Cohort Study.

Altered purine metabolism at reperfusion affects clinical outcome in lung transplantation.

Endobronchial ultrasound-guided bipolar radiofrequency ablation for lung cancer: A first-in-human clinical trial.

Outcomes of lung transplantation at a Canadian center using donors declined in the United States.

Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantation.

Successful sequential transplantation of 2 single lungs from the same donor into 2 different recipients-use of standard cold preservation and 10 °C preservation.

A Biomarker-Based Approach for the Determination of Sample Adequacy During Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A Proof of Concept Study.

A practical and immediately available size-match strategy improves short and long term outcomes in lung transplantation.

Statin Use May Be Associated With a Lower Risk of Invasive Aspergillosis in Lung Transplant Recipients.

Successful 3-day lung preservation using a cyclic normothermic ex vivo lung perfusion strategy.

Successful use of a hepatitis C viremic donor in pediatric bilateral lobar lung transplantation.

Human organ repair centers: Fact or fiction?

Utility of bile acids in large airway bronchial wash versus bronchoalveolar lavage as biomarkers of microaspiration in lung transplant recipients: a retrospective cohort study.

Strategies for lung- and diaphragm-protective ventilation in acute hypoxemic respiratory failure: a physiological trial.

A biomarker assay to risk-stratify patients with symptoms of respiratory tract infection.

The molecular features of chronic lung allograft dysfunction in lung transplant airway mucosa.

The Association Between Extravascular Lung Water and Critical Care Outcomes Following Bilateral Lung Transplantation.

Reflux Surgery in Lung Transplantation: A Multicenter Retrospective Study.

Outcomes of lung transplantation from donors with a history of substance abuse.

Evaluation of 10°C as the optimal storage temperature for aspiration-injured donor lungs in a large animal transplant model.

Thrombopoietin participates in platelet activation in COVID-19 patients.

Determining the impact of ex-vivo lung perfusion on hospital costs for lung transplantation: A retrospective cohort study.

L-alanyl-L-glutamine modified perfusate improves human lung cell functions and extend porcine ex vivo lung perfusion.

Influence of anterior tumor location on survival after resection of lung cancer invading the thoracic inlet (Pancoast tumors).

Testing the delivery of human organ transportation with drones in the real world.

102nd American Association for Thoracic Surgery Presidential Address: What's next?

Low-Flow Inflation Pressure-Time Curve to Identify Airway Opening Pressure in a Patient Receiving Venovenous Extracorporeal Membrane Oxygenation.

Donor and recipient human leukocyte antigen-G polymorphisms modulate the risk of adverse immunologic events following lung transplantation.

Triaging donor lungs based on a microaspiration signature that predicts adverse recipient outcome.

Donor Batf3 inhibits murine lung allograft rejection and airway fibrosis.

Lung Transplantation for Primary Ciliary Dyskinesia and Kartagener Syndrome: A Multicenter Study.

Immunohistochemical Analysis of Lymphocyte Populations in Acute Skin Rejection: The University Health Network Addition to the Banff Classification.

Vascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling.

Pulmonary epithelial markers in phenotypes of chronic lung allograft dysfunction.

Alpha-1-antitrypsin safely promotes rapid recovery of pigs after lung transplantation.

Evaluating the Impact of Ex Vivo Lung Perfusion on Organ Transplantation: A Retrospective Cohort Study.

Outcomes after flow cytometry crossmatch-positive lung transplants managed with perioperative desensitization.

Outcomes of patients with respiratory failure declined for extracorporeal membrane oxygenation: a prospective observational study.

Defining a natural killer cell-enriched molecular rejection-like state in lung transplant transbronchial biopsies.

Intra-subject variability in oscillometry correlates with acute rejection and CLAD post-lung transplant.

Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression.

A Novel Tissue Preservation and Transport Solution as a Substitute for Formalin.

Mesenchymal Stromal Cell Therapy in Lung Transplantation.

Time to extubation for lung transplant recipients represents a pragmatic end-point to guide the development of prognostic tests.

Incidence of post-transplant cytomegalovirus viremia in patients receiving lungs after ex vivo lung perfusion.

Identification of regional variation in gene expression and inflammatory proteins in donor lung tissue and ex vivo lung perfusate.

Extending the age criteria of lung transplant donors to 70+ years old does not significantly affect recipient survival.

Pregnancy and pulmonary hypertension in the pre-lung transplant patient: Successfully saving two lives with extracorporeal lung support.

A machine-learning approach to human ex vivo lung perfusion predicts transplantation outcomes and promotes organ utilization.

Center variability in the prognostic value of a cumulative acute cellular rejection "A-score" for long-term lung transplant outcomes.

De Novo Design and Development of a Nutrient-Rich Perfusate for Ex Vivo Lung Perfusion with Cell Culture Models.

Necroptosis in Organ Transplantation: Mechanisms and Potential Therapeutic Targets.

THE IMPACT OF INTRA-OPERATIVE THERAPEUTIC PLASMA EXCHANGE ON BLEEDING IN LUNG TRANSPLANTATION.

Oesophageal stasis is a risk factor for chronic lung allograft dysfunction and allograft failure in lung transplant recipients.

Acellular ex vivo lung perfusate silences pro-inflammatory signaling in human lung endothelial and epithelial cells.

Donor IL-17 receptor A regulates LPS-potentiated acute and chronic murine lung allograft rejection.