Marianna A Tryfonidou

Leaping the hurdles in developing regenerative treatments for the intervertebral disc from preclinical to clinical.

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species.

Inflammatory cytokines and the nuclear vitamin D receptor are implicated in the pathophysiology of dental resorptive lesions in cats.

Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats.

Intraspecies disparity in growth rate is associated with differences in expression of local growth plate regulators.

Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration.

Intervertebral disc degeneration in the dog. Part 2: chondrodystrophic and non-chondrodystrophic breeds.

Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration.

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies.

Increased osmolarity and cell clustering preserve canine notochordal cell phenotype in culture.

Stem cells in the canine pituitary gland and in pituitary adenomas.

Potential regenerative treatment strategies for intervertebral disc degeneration in dogs.

Genome wide analysis indicates genes for basement membrane and cartilage matrix proteins as candidates for hip dysplasia in Labrador Retrievers.

The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes.

Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal cells.

The Effects of Naproxen on Chondrogenesis of Human Mesenchymal Stem Cells.

Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration.

Increased bone morphogenetic protein 7 signalling in the kidneys of dogs affected with a congenital portosystemic shunt.

Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas.

Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration.

Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model.

The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs.

The Stimulatory Effect of Notochordal Cell-Conditioned Medium in a Nucleus Pulposus Explant Culture.

Characterization and Comparison of Canine Multipotent Stromal Cells Derived from Liver and Bone Marrow.

Pedicle screw-rod fixation: a feasible treatment for dogs with severe degenerative lumbosacral stenosis.

Inflammatory profiles in canine intervertebral disc degeneration.

Increased caveolin-1 in intervertebral disc degeneration facilitates repair.

Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: implications for IVD regeneration.

Bone Morphogenetic Protein-2, But Not Mesenchymal Stromal Cells, Exert Regenerative Effects on Canine and Human Nucleus Pulposus Cells.

Lack of Ubiquitin Specific Protease 8 (USP8) Mutations in Canine Corticotroph Pituitary Adenomas.

Intradiscal application of a PCLA-PEG-PCLA hydrogel loaded with celecoxib for the treatment of back pain in canines: What's in it for humans?

Growth plate expression profiling: Large and small breed dogs provide new insights in endochondral bone formation.

The Myth of Fibroid Degeneration in the Canine Intervertebral Disc: A Histopathological Comparison of Intervertebral Disc Degeneration in Chondrodystrophic and Nonchondrodystrophic Dogs.

Phosphate Functional Groups Improve Oligo[(Polyethylene Glycol) Fumarate] Osteoconduction and BMP-2 Osteoinductive Efficacy.

Link-N: The missing link towards intervertebral disc repair is species-specific.

Focal adhesion signaling affects regeneration by human nucleus pulposus cells in collagen- but not carbohydrate-based hydrogels.

Comparing Hydrogels for Human Nucleus Pulposus Regeneration: Role of Osmolarity During Expansion.

Bone morphogenetic protein-2 release profile modulates bone formation in phosphorylated hydrogel.

In Vitro and In Vivo Correlation of Bone Morphogenetic Protein-2 Release Profiles from Complex Delivery Vehicles.

IL4-10 fusion protein has chondroprotective, anti-inflammatory and potentially analgesic effects in the treatment of osteoarthritis.

Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside.

Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis.

Notochordal cell matrix: An inhibitor of neurite and blood vessel growth?

The Osteoinductive Effect of Controlled Bone Morphogenic Protein 2 Release Is Location Dependent.

Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model.

Effect of Biomaterial Electrical Charge on Bone Morphogenetic Protein-2-Induced Bone Formation.

Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems.

Sequential Treatment of a Large Pituitary Corticotroph Neoplasm and Associated Neurological Signs in a Dog.

Dog as a Model for Osteoarthritis: The FGF4 Retrogene Insertion May Matter.

Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing.

Instrumented cervical fusion in nine dogs with caudal cervical spondylomyelopathy.

Aquaporin expression in the human and canine intervertebral disc during maturation and degeneration.

Hedgehog proteins and parathyroid hormone-related protein are involved in intervertebral disc maturation, degeneration, and calcification.

Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration.

Characterization of biomaterials intended for use in the nucleus pulposus of degenerated intervertebral discs.

"Old Drugs, New Tricks" - Local controlled drug release systems for treatment of degenerative joint disease.

Transformed Canine and Murine Mesenchymal Stem Cells as a Model for Sarcoma with Complex Genomics.

Biomechanical effects of a titanium intervertebral cage as a stand-alone device, and in combination with locking plates in the canine caudal cervical spine.

Enhanced Extracellular Matrix Breakdown Characterizes the Early Distraction Phase of Canine Knee Joint Distraction.

Recognizing the ethical implications of stem cell research: A call for broadening the scope.

A comprehensive tool box for large animal studies of intervertebral disc degeneration.

A perspective on the initiative to develop a multi-species histopathology series.

Selection of Highly Proliferative and Multipotent Meniscus Progenitors through Differential Adhesion to Fibronectin: A Novel Approach in Meniscus Tissue Engineering.

Prospective Evaluation of Local Sustained Release of Celecoxib in Dogs with Low Back Pain.

The genomic profiling and MAMLD1 expression in human and canines with Cushing's disease.

Sustained Intra-Articular Release and Biocompatibility of Tacrolimus (FK506) Loaded Monospheres Composed of [PDLA-PEG]--[PLLA] Multi-Block Copolymers in Healthy Horse Joints.

The function of CD146 in human annulus fibrosus cells and mechanism of the regulation by TGF-β.

A bovine nucleus pulposus explant culture model.

Comparing Hip Dysplasia in Dogs and Humans: A Review.

Cell sources proposed for nucleus pulposus regeneration.

Patient-specific 3D-printed shelf implant for the treatment of hip dysplasia tested in an experimental animal pilot in canines.

Injectable Hydrogels for Articular Cartilage and Nucleus Pulposus Repair: Status Quo and Prospects.

Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids.

Intervertebral disc degeneration in warmblood horses: Histological and biochemical characterization.

Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration.

Roles and responsibilities in stem cell research: a focus group study with stem cell researchers and patients.

Detergent-Free Decellularization of Notochordal Cell-Derived Matrix Yields a Regenerative, Injectable, and Swellable Biomaterial.

Intradiscal injection of human recombinant BMP-4 does not reverse intervertebral disc degeneration induced by nuclectomy in sheep.

Hyperosmolar expansion medium improves nucleus pulposus cell phenotype.

Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients.

Lack of concentration-dependent local toxicity of highly concentrated (5%) versus conventional 0.5% bupivacaine following musculoskeletal surgery in a rat model.

Harmonization and standardization of nucleus pulposus cell extraction and culture methods.

Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue.

Mechanical characterization of a novel biomimetic artificial disc for the cervical spine.

Acetabular rim extension using a personalized titanium implant for treatment of hip dysplasia in dogs: short-term results.

Biomechanical evaluation of a novel biomimetic artificial intervertebral disc in canine cervical cadaveric spines.

A Combined Western and Bead-Based Multiplex Platform to Characterize Extracellular Vesicles.

Semi-synthetic degradable notochordal cell-derived matrix hydrogel for use in degenerated intervertebral discs: Initial in vitro characterization.

An insight on the -glycome of notochordal cell-rich porcine nucleus pulposus during maturation.

Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization.

Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes.

Targeted screening of inflammatory mediators in spontaneous degenerative disc disease in dogs reveals an upregulation of the tumor necrosis superfamily.

and models define a molecular signature reference for human embryonic notochordal cells.

Automatic grading of intervertebral disc degeneration in lumbar dog spines.