Translational Research Institute
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Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy.
American journal of physiology. Endocrinology and metabolism Nov, 2019 | Pubmed ID: 31479303
Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes.
Physiological genomics Nov, 2019 | Pubmed ID: 31588872
Decreased Mitochondrial Dynamics Is Associated with Insulin Resistance, Metabolic Rate, and Fitness in African Americans.
The Journal of clinical endocrinology and metabolism Apr, 2020 | Pubmed ID: 31833547
Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults.
The journals of gerontology. Series A, Biological sciences and medical sciences Sep, 2020 | Pubmed ID: 31907525
Exercise and Muscle Lipid Content, Composition, and Localization: Influence on Muscle Insulin Sensitivity.
Diabetes May, 2020 | Pubmed ID: 32312901
Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles.
Aging cell Jun, 2020 | Pubmed ID: 32468656
Sedentary and Trained Older Men Have Distinct Circulating Exosomal microRNA Profiles at Baseline and in Response to Acute Exercise.
Frontiers in physiology , 2020 | Pubmed ID: 32587527
Rebuttal from Bret H. Goodpaster.
The Journal of physiology Sep, 2020 | Pubmed ID: 32643157
CrossTalk proposal: Intramuscular lipid accumulation causes insulin resistance.
The Journal of physiology Sep, 2020 | Pubmed ID: 32643165
Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging.
Frontiers in physiology , 2020 | Pubmed ID: 32903666
Individual Response Variation in the Effects of Weight Loss and Exercise on Insulin Sensitivity and Cardiometabolic Risk in Older Adults.
Frontiers in endocrinology , 2020 | Pubmed ID: 33013705
A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function.
Circulation Jan, 2021 | Pubmed ID: 33106031
Estimating cardiorespiratory fitness in older adults using a usual-paced 400-m long-distance corridor walk.
Journal of the American Geriatrics Society Nov, 2021 | Pubmed ID: 34269423
Twenty-four hour assessments of substrate oxidation reveal differences in metabolic flexibility in type 2 diabetes that are improved with aerobic training.
Diabetologia Oct, 2021 | Pubmed ID: 34402932
Weight Loss and Exercise Differentially Affect Insulin Sensitivity, Body Composition, Cardiorespiratory Fitness, and Muscle Strength in Older Adults With Obesity: A Randomized Controlled Trial.
The journals of gerontology. Series A, Biological sciences and medical sciences May, 2022 | Pubmed ID: 34406407
The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?
Diabetes Nov, 2021 | Pubmed ID: 34711670
Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults.
American journal of physiology. Endocrinology and metabolism Mar, 2022 | Pubmed ID: 35068187
Exerkines in health, resilience and disease.
Nature reviews. Endocrinology May, 2022 | Pubmed ID: 35304603
Reply to 'Lactate as a major myokine and exerkine'.
Nature reviews. Endocrinology Nov, 2022 | Pubmed ID: 35915255
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary.
GeroScience Feb, 2023 | Pubmed ID: 36242693
Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging.
The journals of gerontology. Series A, Biological sciences and medical sciences Aug, 2023 | Pubmed ID: 36462195
Intermuscular adipose tissue in metabolic disease.
Nature reviews. Endocrinology May, 2023 | Pubmed ID: 36564490
The mitochondrial multi-omic response to exercise training across tissues.
bioRxiv : the preprint server for biology Jan, 2023 | Pubmed ID: 36711881
Dual Roles of Cardiorespiratory Fitness and Fatigability in the Life-Space Mobility of Older Adults: The Study of Muscle, Mobility and Aging (SOMMA).
The journals of gerontology. Series A, Biological sciences and medical sciences Aug, 2023 | Pubmed ID: 36715332
The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility.
The journals of gerontology. Series A, Biological sciences and medical sciences Oct, 2023 | Pubmed ID: 36754371
Exercise and ageing impact the kynurenine/tryptophan pathway and acylcarnitine metabolite pools in skeletal muscle of older adults.
The Journal of physiology Jun, 2023 | Pubmed ID: 36814134
Lower mitochondrial respiration does not lead to decreased fat oxidation in young African American women without obesity.
Obesity (Silver Spring, Md.) May, 2023 | Pubmed ID: 37140394
Validation of the Pittsburgh Performance Fatigability Index in the Study of Muscle, Mobility and Aging.
The journals of gerontology. Series A, Biological sciences and medical sciences Dec, 2023 | Pubmed ID: 37566383
Associations between skeletal muscle energetics and accelerometry-based performance fatigability: Study of Muscle, Mobility and Aging.
Aging cell Oct, 2023 | Pubmed ID: 37843879
Vigor to Frailty As a Continuum-A New Approach in the Study of Muscle, Mobility, and Aging Cohort.
The journals of gerontology. Series A, Biological sciences and medical sciences Jan, 2024 | Pubmed ID: 37847228
Signatures of Cysteine Oxidation on Muscle Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults: Study of Muscle, Mobility and Aging (SOMMA).
medRxiv : the preprint server for health sciences Nov, 2023 | Pubmed ID: 37986748
Associations between DCr muscle mass and MR thigh muscle volume with strength, power, physical performance, fitness, and limitations in older adults in the SOMMA study.
medRxiv : the preprint server for health sciences Nov, 2023 | Pubmed ID: 37986809
Usual-paced 400 m long distance corridor walk estimates cardiorespiratory fitness among older adults: The Study of Muscle, Mobility and Aging.
Journal of the American Geriatrics Society Mar, 2024 | Pubmed ID: 38149438
Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging.
The journals of gerontology. Series A, Biological sciences and medical sciences Apr, 2024 | Pubmed ID: 38150179
The Association of Skeletal Muscle Energetics With Recurrent Falls in Older Adults Within the Study of Muscle, Mobility and Aging.
The journals of gerontology. Series A, Biological sciences and medical sciences Apr, 2024 | Pubmed ID: 38206375
Understanding the variation in exercise responses to guide personalized physical activity prescriptions.
Cell metabolism Apr, 2024 | Pubmed ID: 38262420
Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA).
Aging cell Feb, 2024 | Pubmed ID: 38332629
Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA).
Journal of sport and health science Feb, 2024 | Pubmed ID: 38341136
Chronic exercise improves hepatic acylcarnitine handling.
iScience Mar, 2024 | Pubmed ID: 38361627
Associations of Skeletal Muscle Mass, Muscle Fat Infiltration, Mitochondrial Energetics, and Cardiorespiratory Fitness With Liver Fat Among Older Adults.
The journals of gerontology. Series A, Biological sciences and medical sciences Apr, 2024 | Pubmed ID: 38366047
Associations Between D3Cr Muscle Mass and Magnetic Resonance Thigh Muscle Volume With Strength, Power, Physical Performance, Fitness, and Limitations in Older Adults in the SOMMA Study.
The journals of gerontology. Series A, Biological sciences and medical sciences Apr, 2024 | Pubmed ID: 38367212
Cardiopulmonary Exercise Testing in a Prospective Multicenter Cohort of Older Adults.
Medicine and science in sports and exercise Apr, 2024 | Pubmed ID: 38598351
Muscle mitochondrial bioenergetic capacities are associated with multimorbidity burden in older adults: the Study of Muscle, Mobility and Aging (SOMMA).
The journals of gerontology. Series A, Biological sciences and medical sciences Apr, 2024 | Pubmed ID: 38605684
Line O. Elingaard-Larsen1,2,
Katie L. Whytock1,
Adeline Divoux1,
Meghan Hopf1,
Erin E. Kershaw3,
Jamie N. Justice4,
Bret H. Goodpaster1,
Nancy E. Lane5,
Lauren M. Sparks1
1Translational Research Institute, AdventHealth,
2, Steno Diabetes Center Copenhagen,
3Division of Endocrinology and Metabolism, University of Pittsburgh,
4Gerontology and Geriatric Medicine, Wake Forest University School of Medicine,
5Department of Internal Medicine - Rheumatology, Allergy, and Clinical Immunology, University of California Davis Health
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