Department of Infectious Diseases,
Respiratory Medicine and Critical Care,
Department of Infectious Diseases, Respiratory Medicine and Critical Care
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Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication.
The Journal of biological chemistry Nov, 2006 | Pubmed ID: 16984921
IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein.
Cellular microbiology Apr, 2007 | Pubmed ID: 17140406
Extra- and intracellular innate immune recognition in endothelial cells.
Thrombosis and haemostasis Aug, 2007 | Pubmed ID: 17721613
Role of Toll-like receptors, NOD-like receptors and RIG-I-like receptors in endothelial cells and systemic infections.
Thrombosis and haemostasis Dec, 2009 | Pubmed ID: 19967140
Innate immune recognition in infectious and noninfectious diseases of the lung.
American journal of respiratory and critical care medicine Jun, 2010 | Pubmed ID: 20167850
Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.
Critical care (London, England) Jan, 2015 | Pubmed ID: 25888164
Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.
Current topics in microbiology and immunology , 2016 | Pubmed ID: 27460812
Innate sensing and cell-autonomous resistance pathways in Legionella pneumophila infection.
International journal of medical microbiology : IJMM Jan, 2018 | Pubmed ID: 29097162
The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans.
Infection and immunity Mar, 2018 | Pubmed ID: 29263110
The microbiota in pneumonia: From protection to predisposition.
Science translational medicine Jan, 2021 | Pubmed ID: 33441423
Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Nature communications Mar, 2024 | Pubmed ID: 38555356
Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19.
NPJ biofilms and microbiomes Aug, 2024 | Pubmed ID: 39085233
Natascha Drude1,
Kai Diederich2,
Claudia U. Duerr3,
Nadine Haase4,
Christoph Harms5,6,7,8,
Frank Heppner9,10,11,
Marina Jendrach9,10,11,
Pia Kahnau2,
Marina Kolesnichenko12,
Lars Lewejohann2,13,
Claudia Kurreck1,
Anke Lohan14,
Marcus A. Mall15,16,
Dominik Müller4,
Stefan Nagel-Riedasch14,
Bastian Opitz17,
Laura Schaupp15,16,
Gilbert Schönfelder2,18,
Amelie Weber3,
Gerald Willimsky19,20,21,
Yalei Zang1,22,
Stephan P. Rosshart*,23,24,
Andreas Diefenbach*,3,
Stefan Jordan*,3
1BIH QUEST Center for Responsible Research, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin,
2German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R),
3Institute of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
4, Experimental and Clinical Research Center (ECRC) & Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC),
5Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie,
6Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
7, Einstein Center for Neuroscience,
8, German Center for Cardiovascular Research (DZHK), partner site Berlin,
9Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
10, Cluster of Excellence, NeuroCure,
11, German Center for Neurodegenerative Diseases (DZNE) Berlin,
12Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
13Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Freie Universität Berlin,
14Forschungseinrichtungen für Experimentelle Medizin/FEM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
15Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
16, German Center for Lung Research (DZL), associated partner site, Berlin,
17Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
18Division of Toxicology, Institute of Clinical Pharmacology and Toxicology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health,
19Institute of Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
20, German Cancer Research Center,
21, German Cancer Consortium, partner site Berlin,
22Department of Radiology (including Pediatric Radiology), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
23Department of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),
24Department of Medicine II, Faculty of Medicine, Medical Center - University of Freiburg
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