Ulrich H. Koszinowski

The glycoprotein gp48 of murine cytomegalovirusL proteasome-dependent cytosolic dislocation and degradation.

MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo.

The murine cytomegalovirus immunomodulatory gene m152 prevents recognition of infected cells by M45-specific CTL but does not alter the immunodominance of the M45-specific CD8 T cell response in vivo.

Herpesvirus genetics has come of age.

Cytomegalovirus recruitment of cellular kinases to dissolve the nuclear lamina.

The human cytomegalovirus ribonucleotide reductase homolog UL45 is dispensable for growth in endothelial cells, as determined by a BAC-cloned clinical isolate of human cytomegalovirus with preserved wild-type characteristics.

Major histocompatibility complex class I allele-specific cooperative and competitive interactions between immune evasion proteins of cytomegalovirus.

Effective inhibition of K(b)- and D(b)-restricted antigen presentation in primary macrophages by murine cytomegalovirus.

A gammaherpesvirus G protein-coupled receptor homologue is required for increased viral replication in response to chemokines and efficient reactivation from latency.

Memory inflation: continuous accumulation of antiviral CD8+ T cells over time.

Cloning of herpesviral genomes as bacterial artificial chromosomes.

Dendritic cells under influence of mouse cytomegalovirus have a physiologic dual role: to initiate and to restrict T cell activation.

Role of murine cytomegalovirus US22 gene family members in replication in macrophages.

Vaccination of mice with bacteria carrying a cloned herpesvirus genome reconstituted in vivo.

The human cytomegalovirus UL45 gene product is a late, virion-associated protein and influences virus growth at low multiplicities of infection.

The limits of protection by "memory" T cells in Ig-/- mice persistently infected with a gamma-herpesvirus.

Expansion of protective CD8+ T-cell responses driven by recombinant cytomegaloviruses.

Mutagenesis of viral BACs with linear PCR fragments (ET recombination).

Murine cytomegalovirus interference with antigen presentation has little effect on the size or the effector memory phenotype of the CD8 T cell response.

Gain of virulence caused by loss of a gene in murine cytomegalovirus.

Comprehensive mutational analysis of a herpesvirus gene in the viral genome context reveals a region essential for virus replication.

Conditional cytomegalovirus replication in vitro and in vivo.

NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145.

Selective down-regulation of the NKG2D ligand H60 by mouse cytomegalovirus m155 glycoprotein.

Use of a murine cytomegalovirus K181-derived bacterial artificial chromosome as a vaccine vector for immunocontraception.

Viruses know it all: new insights into IFN networks.

Frequent coinfection of cells explains functional in vivo complementation between cytomegalovirus variants in the multiply infected host.

Functional domains of murine cytomegalovirus nuclear egress protein M53/p38.

The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60.

Coordinated function of murine cytomegalovirus genes completely inhibits CTL lysis.

Common and specific properties of herpesvirus UL34/UL31 protein family members revealed by protein complementation assay.

Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1.

Random screening for dominant-negative mutants of the cytomegalovirus nuclear egress protein M50.

Engineering of cytomegalovirus genomes for recombinant live herpesvirus vaccines.

Natural killer cells promote early CD8 T cell responses against cytomegalovirus.

Targeted deletion of regions rich in immune-evasive genes from the cytomegalovirus genome as a novel vaccine strategy.

Dominant-negative FADD rescues the in vivo fitness of a cytomegalovirus lacking an antiapoptotic viral gene.

Conditional gene expression systems to study herpesvirus biology in vivo.

Dissection of the antiviral NK cell response by MCMV mutants.

The major virus-producing cell type during murine cytomegalovirus infection, the hepatocyte, is not the source of virus dissemination in the host.

High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay.

Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response.

Cytomegalovirus microRNAs.

Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus.

Conserved principles of mammalian transcriptional regulation revealed by RNA half-life.

Virology. A vaccine monkey wrench?

Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay.

Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1.

Dominant negative mutants of the murine cytomegalovirus M53 gene block nuclear egress and inhibit capsid maturation.

Cytomegalovirus microRNAs facilitate persistent virus infection in salivary glands.

Human cytomegalovirus disrupts the major histocompatibility complex class I peptide-loading complex and inhibits tapasin gene transcription.

HCMV spread and cell tropism are determined by distinct virus populations.

The role of cell types in cytomegalovirus infection in vivo.

M94 is essential for the secondary envelopment of murine cytomegalovirus.

Virus progeny of murine cytomegalovirus bacterial artificial chromosome pSM3fr show reduced growth in salivary Glands due to a fixed mutation of MCK-2.

Dominant-negative proteins in herpesviruses - from assigning gene function to intracellular immunization.

Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.

Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.

A cell free protein fragment complementation assay for monitoring the core interaction of the human cytomegalovirus nuclear egress complex.

Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo.

A beta-herpesvirus with fluorescent capsids to study transport in living cells.

Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein.

The polyomaviruses WUPyV and KIPyV: a retrospective quantitative analysis in patients undergoing hematopoietic stem cell transplantation.

Characterization of conserved region 2-deficient mutants of the cytomegalovirus egress protein pM53.

Systemic and local infection routes govern different cellular dissemination pathways during gammaherpesvirus infection in vivo.

Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.

The Viral Chemokine MCK-2 of Murine Cytomegalovirus Promotes Infection as Part of a gH/gL/MCK-2 Complex.