Jason W. Rausch
RT Biochemistry Section,
HIV Drug Resistance Program,
RT Biochemistry Section, HIV Drug Resistance Program
Frederick National Laboratory for Cancer Research
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Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity.
Biochemistry Apr, 2002 | Pubmed ID: 11939780
Mutations in the ribonuclease H active site of HIV-RT reveal a role for this site in stabilizing enzyme-primer-template binding.
Biochemistry Sep, 2002 | Pubmed ID: 12206668
Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2003 | Pubmed ID: 12972638
Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract.
Nucleic acids research , 2004 | Pubmed ID: 15004241
'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus.
The international journal of biochemistry & cell biology Sep, 2004 | Pubmed ID: 15183342
Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis.
Nucleic acids research , 2007 | Pubmed ID: 17164285
Exploiting structurally diverse nucleoside analogs as probes of reverse transcription complexes.
Current HIV research Jan, 2007 | Pubmed ID: 17266554
Structural probing of the HIV-1 polypurine tract RNA:DNA hybrid using classic nucleic acid ligands.
Nucleic acids research May, 2008 | Pubmed ID: 18400780
Dynamic binding orientations direct activity of HIV reverse transcriptase.
Nature May, 2008 | Pubmed ID: 18464735
Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates.
Science (New York, N.Y.) Nov, 2008 | Pubmed ID: 19008444
Dissecting APOBEC3G substrate specificity by nucleoside analog interference.
The Journal of biological chemistry Mar, 2009 | Pubmed ID: 19136562
Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.
Biochimica et biophysica acta May, 2010 | Pubmed ID: 19665597
HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN).
The Journal of biological chemistry Jan, 2010 | Pubmed ID: 19833723
Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.
Antimicrobial agents and chemotherapy Sep, 2010 | Pubmed ID: 20547794
Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
Journal of medicinal chemistry Jul, 2011 | Pubmed ID: 21568335
Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid.
Nucleic acids research Apr, 2013 | Pubmed ID: 23382176
Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome.
Nucleic acids research May, 2013 | Pubmed ID: 23531545
The HIV-2 Rev-response element: determining secondary structure and defining folding intermediates.
Nucleic acids research May, 2013 | Pubmed ID: 23640333
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