Gil Atzmon

Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?

Plasma HDL levels highly correlate with cognitive function in exceptional longevity.

Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms.

Unique lipoprotein phenotype and genotype associated with exceptional longevity.

Clinical phenotype of families with longevity.

Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action.

The paradox of the insulin/IGF-1 signaling pathway in longevity.

Biological evidence for inheritance of exceptional longevity.

Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity.

Differential responses of visceral and subcutaneous fat depots to nutrients.

Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging.

Lipoprotein genotype and conserved pathway for exceptional longevity in humans.

Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action.

Serum heat shock protein 70 level as a biomarker of exceptional longevity.

Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo.

Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians.

Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging.

Accretion of visceral fat and hepatic insulin resistance in pregnant rats.

Functionally significant insulin-like growth factor I receptor mutations in centenarians.

Visceral adipose tissue modulates mammalian longevity.

QTLs detected in a multigenerational resource chicken population.

Adiponectin levels and genotype: a potential regulator of life span in humans.

Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance.

Ashkenazi Jewish centenarians do not demonstrate enrichment in mitochondrial haplogroup J.

Extreme longevity is associated with increased serum thyrotropin.

Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.

Humanin: a novel central regulator of peripheral insulin action.

Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity.

Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians.

RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.

Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.

Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease.

Tissue-specific dysregulation of DNA methylation in aging.

Aging per se increases the susceptibility to free fatty acid-induced insulin resistance.

Cholesteryl ester transfer protein (CETP) genotype and reduced CETP levels associated with decreased prevalence of hypertension.

Abraham's children in the genome era: major Jewish diaspora populations comprise distinct genetic clusters with shared Middle Eastern Ancestry.

Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice.

Genetic studies reveal the role of the endocrine and metabolic systems in aging.

The history of African gene flow into Southern Europeans, Levantines, and Jews.

A genome-wide association study of aging.

Lifestyle factors of people with exceptional longevity.

Exceptional longevity is associated with decreased reproduction.

Human longevity and common variations in the LMNA gene: a meta-analysis.

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.

Family history of exceptional longevity is associated with lower serum uric acid levels in Ashkenazi Jews.

Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.

Positive attitude towards life and emotional expression as personality phenotypes for centenarians.

Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing.

North African Jewish and non-Jewish populations form distinctive, orthogonal clusters.

Epigenetic genome-wide association methylation in aging and longevity.

Gene size matters.

Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immunosorbent assay (ELISA).

Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing.

Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice.

Personality, self-rated health, and cognition in centenarians: do personality and self-rated health relate to cognitive function in advanced age?