Alyssa H. Hasty

Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha.

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.

Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice.

The recycling of apolipoprotein E in primary cultures of mouse hepatocytes. Evidence for a physiologic connection to high density lipoprotein metabolism.

Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance.

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.

Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters.

The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I.

Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.

Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice.

Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I.

Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice.

Plasminogen activator inhibitor-1 modulates adipocyte differentiation.

Physiological relevance of apolipoprotein E recycling: studies in primary mouse hepatocytes.

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.

Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells.

Quantitation and cellular localization of 11beta-HSD1 expression in murine thymus.

The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages.

Effects of vitamin E on oxidative stress and atherosclerosis in an obese hyperlipidemic mouse model.

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.

Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.

Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue.

Obesity causes very low density lipoprotein clearance defects in low-density lipoprotein receptor-deficient mice.

Obesity potentiates development of fatty liver and insulin resistance, but not atherosclerosis, in high-fat diet-fed agouti LDLR-deficient mice.

Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction.

Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice.

Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis.

Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice.

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice.

The role of macrophage leptin receptor in aortic root lesion formation.

Atherosclerotic lesion formation and triglyceride storage in obese apolipoprotein AI-deficient mice.

Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion.

Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.

Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.

Macrophage infiltration into adipose tissue: initiation, propagation and remodeling.

Lipid and phospholipid profiling of biological samples using MALDI Fourier transform mass spectrometry.

Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia.

Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome.

Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces lipotoxicity in macrophages.

Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.

Dietary fish oil exerts hypolipidemic effects in lean and insulin sensitizing effects in obese LDLR-/- mice.

The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue.

Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice.

Mouse models of the metabolic syndrome.

Adipose tissue recruitment of leukocytes.

Absence of macrophage inflammatory protein-1{alpha} does not impact macrophage accumulation in adipose tissue of diet-induced obese mice.

The role of adipose tissue in mediating the beneficial effects of dietary fish oil.

Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice delays improvements in insulin sensitivity.

Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity.

Impact of macrophage inflammatory protein-1α deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion.

Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.

Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages.

Endoplasmic reticulum stress and hypertension - a new paradigm?