Institut für Zelluläre und Molekulare Physiologie
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Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.
Pflugers Archiv : European journal of physiology Jun, 2014 | Pubmed ID: 24906497
Basolateral PAR-2 receptors mediate KCl secretion and inhibition of Na+ absorption in the mouse distal colon.
The Journal of physiology Feb, 2002 | Pubmed ID: 11850514
Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel.
The Journal of biological chemistry Jun, 2002 | Pubmed ID: 11927600
Cystic fibrosis transmembrane conductance regulator-dependent up-regulation of Kir1.1 (ROMK) renal K+ channels by the epithelial sodium channel.
The Journal of biological chemistry Jul, 2002 | Pubmed ID: 11994290
Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.
The Journal of biological chemistry Aug, 2002 | Pubmed ID: 12050153
The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jan, 2003 | Pubmed ID: 12424229
The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1.
Journal of the American Society of Nephrology : JASN Dec, 2002 | Pubmed ID: 12444200
Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels.
American journal of physiology. Cell physiology Apr, 2003 | Pubmed ID: 12456399
Basolateral adrenoceptor activation mediates noradrenaline-induced Cl- secretion in M-1 mouse cortical collecting duct cells.
Pflügers Archiv : European journal of physiology Dec, 2002 | Pubmed ID: 12466941
The gamma-subunit of ENaC is more important for channel surface expression than the beta-subunit.
American journal of physiology. Cell physiology Feb, 2003 | Pubmed ID: 12529252
cAMP-dependent activation of CFTR inhibits the epithelial sodium channel (ENaC) without affecting its surface expression.
Pflügers Archiv : European journal of physiology Jan, 2003 | Pubmed ID: 12548398
Extracellular Na+ removal attenuates rundown of the epithelial Na+-channel (ENaC) by reducing the rate of channel retrieval.
Pflügers Archiv : European journal of physiology Mar, 2004 | Pubmed ID: 14704795
Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models.
The Journal of biological chemistry May, 2004 | Pubmed ID: 15007059
PGE2 stimulates Cl- secretion in murine M-1 cortical collecting duct cells in an autocrine manner.
Pflügers Archiv : European journal of physiology Jul, 2004 | Pubmed ID: 15127302
A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alpha-subunit.
The Journal of biological chemistry Sep, 2004 | Pubmed ID: 15234985
Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition.
Pflügers Archiv : European journal of physiology Jun, 2006 | Pubmed ID: 16416336
Stimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's beta- and gamma-subunit.
The Journal of biological chemistry Apr, 2006 | Pubmed ID: 16476738
Functional characterization of a novel CFTR mutation P67S identified in a patient with atypical cystic fibrosis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2007 | Pubmed ID: 17495464
(NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and fisher rat thyroid cells.
The Journal of biological chemistry Sep, 2007 | Pubmed ID: 17652085
Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome.
The Journal of physiology Jan, 2008 | Pubmed ID: 18006588
Trypsin can activate the epithelial sodium channel (ENaC) in microdissected mouse distal nephron.
American journal of physiology. Renal physiology Oct, 2008 | Pubmed ID: 18653483
Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels.
The Journal of physiology Oct, 2008 | Pubmed ID: 18669538
Plasmin in nephrotic urine activates the epithelial sodium channel.
Journal of the American Society of Nephrology : JASN Feb, 2009 | Pubmed ID: 19073825
Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC).
Pflügers Archiv : European journal of physiology May, 2009 | Pubmed ID: 19277701
HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury.
The American journal of pathology May, 2009 | Pubmed ID: 19349364
Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease.
Human mutation Jul, 2009 | Pubmed ID: 19462466
The delta-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation.
The Journal of biological chemistry Oct, 2009 | Pubmed ID: 19717556
Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2009 | Pubmed ID: 19910701
Functional characterization of a partial loss-of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2010 | Pubmed ID: 20054153
A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition.
The Journal of physiology Apr, 2010 | Pubmed ID: 20194130
Proteolytic activation of the epithelial sodium channel (ENaC) in health and disease.
The journal of medical investigation : JMI , 2009 | Pubmed ID: 20224211
Protein kinase B alpha (PKBα) stimulates the epithelial sodium channel (ENaC) heterologously expressed in Xenopus laevis oocytes by two distinct mechanisms.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2010 | Pubmed ID: 21220922
Atomic force microscopy reveals the architecture of the epithelial sodium channel (ENaC).
The Journal of biological chemistry Sep, 2011 | Pubmed ID: 21775436
Four subunits (αβγδ) of the epithelial sodium channel (ENaC) are expressed in the human eye in various locations.
Investigative ophthalmology & visual science Feb, 2012 | Pubmed ID: 22167092
An inhibitory peptide derived from the α-subunit of the epithelial sodium channel (ENaC) shows a helical conformation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2012 | Pubmed ID: 22613977
Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S.
Pflügers Archiv : European journal of physiology Oct, 2012 | Pubmed ID: 22864553
Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.
American journal of physiology. Renal physiology Nov, 2012 | Pubmed ID: 22933298
Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel.
The Journal of general physiology Oct, 2012 | Pubmed ID: 22966015
A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect.
American journal of physiology. Lung cellular and molecular physiology Jan, 2013 | Pubmed ID: 23087020
Characterization of the mouse ClC-K1/Barttin chloride channel.
Biochimica et biophysica acta Nov, 2013 | Pubmed ID: 23791703
The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.
The Journal of biological chemistry Aug, 2013 | Pubmed ID: 23818521
Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC).
Pflügers Archiv : European journal of physiology Feb, 2014 | Pubmed ID: 23842738
Proteolytic Activation of the Human Epithelial Sodium Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites.
The Journal of biological chemistry May, 2014 | Pubmed ID: 24841206
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