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Bryant University

2 ARTICLES PUBLISHED IN JoVE

Biochemistry

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Mika Gallati¹, Bryant Point¹, Christopher W. Reid^1,2

¹Department of Science and Technology, Bryant University, ²Center for Health and Behavioral Sciences, Bryant University

A detailed protocol is presented for preparing the bacteriostatic diamide masarimycin, a small molecule probe that inhibits the growth of Bacillus subtilis and Streptococcus pneumoniae by targeting cell wall degradation. Its application as a chemical probe is demonstrated in synergy/antagonism assays and morphological studies with B. subtilis and S. pneumoniae.

Genetics

Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Acadia Joniec^*1, Joseph Leszczynski^*1, Sokhna Ndoye^*1, Jillian Sylvia^*1, Steven E. Weicksel^1,2

¹Department of Biological and Biomedical Sciences, Bryant University, ²Center of Health and Behavioral Sciences, Bryant University

Here, we present an adaption of the chromosome conformation capture (3C) technique in detail with an emphasis on undergraduate involvement and learning.