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Arthur Riggs Diabetes and Metabolism Research Institute

1 ARTICLES PUBLISHED IN JoVE

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Biology

Generating Human Pancreatic Tissue Slices to Study Endocrine and Exocrine Pancreas Physiology
Julia K. Panzer 1, Pablo A. Garcia 1, Alberto Pugliese 1
1Department of Diabetes Immunology, Arthur Riggs Diabetes and Metabolism Research Institute

This protocol describes how to generate human pancreas slices from deceased organ donors to study cell function under near-physiological conditions. This innovative approach enables the investigation of normal and structurally damaged islets and the intricate interplay between endocrine and exocrine compartments.

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