Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and OsteoporosisDavid Alfaiate 1,2, Carlos Mas-Moruno 3,4, Cidália Manuela 5, Josep Maria Ustrell 6,7, Juan Antonio Camara 8,9, Marina Ferrer 10,11, José Maria Manero 3,4, Maria-Cristina Manzanares-Céspedes 12
1Faculty of Medicine and Health Sciences, University of Barcelona, 2Department of Oral Surgery, Davallmed Clinic. Porto, 3Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya, 4Barcelona Research Centre in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, 5Department of Periodontology, Davallmed Clinic. Porto, 6Department of Odontostomatology, University of Barcelona, 7Oral Health and Masticatory System Research Group at the Bellvitge Biomedical Research Institute (IDIBELL), 8Preclinical imaging platform, Vall d'Hebron Research Institute, Barcelona, 9Preclinical Therapeutics Core, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 10Animal facility, Vall d'Hebron Research Institute, Barcelona, 11UCSF Gnotobiotics Core Facility, University of California, San Francisco, 12Human Anatomy and Embryology Unit, Experimental Pathology and Therapeutics Department, Faculty of Medicine and Health Sciences, University of Barcelona
The placement of implants in a rat model is an essential experimental procedure for clinical research. This study presents a comprehensive surgical protocol for implanting titanium implants into the tibia of rat models with diabetes and osteoporosis.
