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the Affiliated Hospital of Guizhou Medical University

2 ARTICLES PUBLISHED IN JoVE

Medicine

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Xiaoyu Tian^*1,2,3, Meng Zhang^*1,2, Yiming Wu⁴, Liying Zhang^1,2, Lingli Zhang^1,2, Xueer Zheng^1,2, Shangkun Ou^1,2, Hao Gu^1,2

¹Department of Ophthalmology, the Affiliated Hospital of Guizhou Medical University, ²School of Clinical Medicine, Guizhou Medical University, ³The Second People's Hospital of Guiyang City, ⁴Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham

We developed a rat model of severe corneal inflammation through corneal epithelium curettage combined with corneal sutures. The study evaluated corneal inflammation patterns, epithelial proliferation, and changes in limbal stem cells under inflammatory conditions.

Medicine

Establishment of A Mouse Model of Aqueous Deficiency Dry Eye

Meng Zhang^*1,2, Xiaoyu Tian^*1,2, Yiming Wu³, Liying Zhang^1,2, Lingli Zhang^1,2, Xueer Zheng^1,2, Shangkun Ou^1,2, Hao Gu^1,2

¹Department of Ophthalmology, the Affiliated Hospital of Guizhou Medical University, ²School of Clinical Medicine, Guizhou Medical University, ³Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham

Here, we present a method to establish a mouse model of aqueous-deficient dry eye by excising the extraorbital and infraorbital lacrimal glands and evaluate the changes in the ocular surface in aqueous deficiency dry eye.