Intravital Longitudinal Imaging of Vascular Dynamics in the Calvarial Bone MarrowAleria Duperray-Susini 1, Thomas Guilbert 2, Jozsua Fodor 3, Julie Lesieur 2, Lakshmi Sandhow 1, Pierre Bourdoncle 2, Diana Passaro 1
1Leukemia and Niche Dynamics laboratory, Institut Cochin, Université Paris Cité UMR-S1016, INSERM U1016, CNRS UMR8104, 2IMAG'IC, Institut Cochin, Université Paris Cité UMR-S1016, INSERM U1016, CNRS UMR8104, 3YMETRY, Institut de Biologie de l'ENS (IBENS), École Normale Supérieure, Université PSL
Intravital microscopy allows the study of dynamic biological processes such as tissue regeneration and tumor development. The calvarial bone marrow, a highly dynamic tissue, offers insights into hematopoiesis and vascular function. Using a biocompatible 3D-printed head fixation implant allows for repetitive longitudinal imaging, enhancing our understanding of tissue dynamics and the tumor microenvironment.
