Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in InfantsPei-Yi Lin 1, Nadege Roche-Labarbe 1,2, Mathieu Dehaes 3, Stefan Carp 1, Angela Fenoglio 3, Beniamino Barbieri 4, Katherine Hagan 1, P. Ellen Grant 3, Maria Angela Franceschini 1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 2Lab. PALM, Université de Caen Basse-Normandie, 3Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, 4ISS, INC.
We combined frequency-domain near-infrared spectroscopy measures of cerebral hemoglobin oxygenation with diffuse correlation spectroscopy measures of cerebral blood flow index to estimate an index of oxygen metabolism. We tested the utility of this measure as a bedside screening tool to evaluate the health and development of the newborn brain.
