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University of Rome Tor Vergata

3 ARTICLES PUBLISHED IN JoVE

Medicine

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

Pietro Gentile^1,2, Simone Garcovich³, Maria Giovanna Scioli⁴, Alessandra Bielli⁴, Augusto Orlandi⁵, Valerio Cervelli⁶

¹Plastic and Reconstructive Surgery Department, University of Rome Tor Vergata, ²Chief of Teaching of Plastic and Reconstructive Surgery, Catholic University, ³Dermatology Department, Catholic University, ⁴Anathomic Pathology Department, University of Rome Tor Vergata, ⁵Chief of Anathomic Pathology Department, University of Rome Tor Vergata, ⁶Chief of Plastic and Reconstructive Surgery Department, University of Rome Tor Vergata

This paper aims to describe the interfollicular autologous platelet-rich plasma injections (0.20 mL x cm²) in the scalp of 23 patients affected by androgenetic alopecia at a depth of 5 mm using a medical injector gun equipped with a 30 gauge needle, in three sessions.

Immunology and Infection

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells

Alessandra Ventura^*1,2, Aaron Vassall^*1, Alp Yurter¹, Eve Robinson¹, Renata Filler¹, Douglas Hanlon¹, Katrina Meeth¹, Harib Ezaldein¹, Michael Girardi¹, Olga Sobolev¹, Marcus W. Bosenberg^1,3, Richard L. Edelson¹

¹Department of Dermatology, Yale University School of Medicine, ²Dermatology Department, University of Rome Tor Vergata, ³Department of Pathology, Yale University School of Medicine

The transimmunization (TI) device or plate and related protocols have been developed to replicate the key features of extracorporeal photochemotherapy (ECP), in an experimental setting, allowing for production of physiologically activated, tunable dendritic cells (DCs) for cancer immunotherapy.

Chemistry

Phase Change Dimethyldioctadecylammonium-Shelled Microdroplets as a Promising Drug Delivery System: Results on 3D Spheroids of Mammalian Tumor Cells

Elisabetta Tortorella^*1,2, Damiano Palmieri^*1, Martina Piermarini¹, Daniele Gigante¹, Letizia Oddo¹, Yosra Toumia¹, Gaio Paradossi¹, Fabio Domenici¹

¹Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, ²Department of Molecular Medicine, Sapienza University of Rome

Decafluoropentane microdroplets developed with a shell of dimethyldioctadecylammonium bromide exhibited an exceptional colloidal stability and an actractive biointerface. DDAB-MDs proved to be efficient drug reservoirs characterized by a high affinity to plasma membranes together with enhanced uptake and antitumor activity of Doxorubicin against human triple-negative breast cancer (MDA-MB-231) 3D model.